Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   FGK99_RS07805 Genome accession   NZ_LR594033
Coordinates   1645227..1647122 (-) Length   631 a.a.
NCBI ID   WP_138119682.1    Uniprot ID   -
Organism   Streptococcus equi subsp. zooepidemicus strain NCTC4675     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1640227..1652122
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGK99_RS07780 (NCTC4675_01578) - 1640971..1641333 (-) 363 WP_012516140.1 S1 RNA-binding domain-containing protein -
  FGK99_RS07785 (NCTC4675_01579) - 1641333..1642733 (-) 1401 WP_138119678.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  FGK99_RS07790 (NCTC4675_01580) - 1642766..1643407 (-) 642 WP_041785672.1 response regulator transcription factor -
  FGK99_RS07795 (NCTC4675_01581) - 1643400..1644404 (-) 1005 WP_138119680.1 sensor histidine kinase -
  FGK99_RS07800 (NCTC4675_01582) liaF 1644401..1645093 (-) 693 WP_012679994.1 cell wall-active antibiotics response protein LiaF -
  FGK99_RS07805 (NCTC4675_01583) pknB 1645227..1647122 (-) 1896 WP_138119682.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  FGK99_RS07810 (NCTC4675_01584) - 1647119..1647859 (-) 741 WP_012516146.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  FGK99_RS07815 (NCTC4675_01585) rsmB 1647897..1649219 (-) 1323 WP_138120027.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  FGK99_RS07820 (NCTC4675_01586) fmt 1649209..1650144 (-) 936 WP_138119684.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68527.69 Da        Isoelectric Point: 6.6073

>NTDB_id=1127194 FGK99_RS07805 WP_138119682.1 1645227..1647122(-) (pknB) [Streptococcus equi subsp. zooepidemicus strain NCTC4675]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKSGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENPNVP
QALENVVIRATAKKLSDRYRSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPITAPKVSAASQASGAADTR
PEQTSQMDTLQKPQKKKKNGRFLGTLLKILFSFFVVGVALFAYLVLTKPTTVKVPDVTGSSLNAAKQVLEEAGLKVGKVH
QIESDTVSEDQVVKTNPQAGSAKRKGSSVDLYLSIGNKGFEMENYKGQDYQDVMTSLTETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGEKFNPAGKSKITLSVAVGDTVIMPMVTEYSYADAVNTLTALGIDAARIKAYTPSSSSPTGFVQVSSPSS
KAIVSGQTPYYGTQISLSEKGDISLYLYPEETRASSSSSSSDTSASNPSAGDTTDSSSHTELGQNDAVITP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=1127194 FGK99_RS07805 WP_138119682.1 1645227..1647122(-) (pknB) [Streptococcus equi subsp. zooepidemicus strain NCTC4675]
ATGATTCAGATTGGCAAGCTATTTGCTGGTCGTTATCGCATTCTAAAATCTATAGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAACGATTTGATTCTGGATAATGAGGACGTTGCCATTAAGGTCTTGCGGACCAATTATCAAACAGATCAGGTTG
CTGTTGCGCGTTTTCAAAGAGAAGCGCGAGCCATGGCTGAATTAAATCACCCCAATATTGTTGCCATTCGGGATATAGGC
GAGGAAGACGGACAGCAATTTTTAGTAATGGAATATGTTGATGGCTCTGATTTGAAAAAATACATTCAGGATCATGCGCC
ATTATCTAACAATGAGGTGGTGAGAATCATGGAAGAGGTTCTTTCTGCCATGACTCTGGCCCACCAAAAAGGAATTGTTC
ACAGGGATTTAAAGCCTCAAAACATTCTTTTGACCAAATCAGGTGTTGTTAAGGTTACAGATTTTGGGATTGCCGTTGCC
TTTGCAGAGACCAGTCTAACCCAGACAAATTCTATGCTAGGAAGTGTGCATTACCTCTCACCTGAGCAAGCGCGTGGTTC
TAAAGCGACGATTCAAAGTGATATTTACGCGATGGGAATTATGCTCTTTGAAATGCTAACAGGGCATATTCCTTATGATG
GCGATAGCGCTGTGACGATTGCTCTGCAGCATTTTCAAAAGCCGCTGCCCTCTATCATTGATGAAAATCCTAATGTGCCT
CAAGCCTTGGAAAACGTTGTTATTCGGGCCACTGCCAAAAAGCTAAGTGACCGTTATCGCTCGACCTTTGAGATGAGCAG
GGATTTGATGACAGCCCTTAGCTATAACCGCAGTCGTGAGCGTAAGGTTATTTTTGATGATGTCGAAAGCACAAAGCCAT
TACCAAAGGTCACACCAGCCCCTATCACAGCACCTAAGGTGTCGGCTGCCAGTCAGGCATCTGGAGCAGCTGATACTAGA
CCTGAGCAGACTAGCCAGATGGACACCCTGCAAAAGCCTCAAAAAAAGAAAAAAAATGGGCGCTTTTTAGGAACGCTCTT
AAAAATCTTATTTTCCTTTTTCGTTGTCGGTGTGGCTCTTTTTGCTTATCTGGTCTTGACCAAGCCAACTACGGTTAAGG
TTCCTGATGTGACAGGCTCTAGTCTCAATGCTGCCAAGCAGGTTTTGGAAGAAGCAGGACTAAAGGTCGGTAAGGTCCAT
CAGATTGAAAGCGACACAGTCAGTGAGGATCAGGTGGTTAAGACAAATCCTCAAGCAGGCTCAGCCAAGCGAAAGGGCTC
CAGCGTTGACCTCTACCTTTCTATCGGAAATAAAGGCTTTGAGATGGAAAATTATAAGGGACAGGATTATCAGGATGTGA
TGACCAGTCTGACTGAGACCTACGGTGTACCAAAGTCAAAAATCAAGATTGAGCGTATCGTGACAAATGAATACCCTGAA
AACACCGTTATTAGCCAGTCACCAAGCGCGGGAGAAAAATTTAACCCAGCTGGTAAATCCAAGATTACGCTTAGTGTAGC
AGTGGGCGATACGGTCATCATGCCAATGGTAACTGAGTACAGCTATGCAGATGCGGTGAATACACTAACAGCCCTAGGAA
TTGACGCCGCAAGGATCAAGGCCTACACTCCAAGCTCAAGCTCTCCGACGGGCTTTGTTCAGGTGAGCTCCCCAAGCTCA
AAGGCGATTGTCAGTGGGCAGACACCGTATTATGGTACCCAGATTAGCCTTTCTGAAAAGGGTGATATTAGCCTCTACCT
CTACCCTGAGGAGACACGTGCATCAAGCAGCTCATCGAGCTCTGATACCTCAGCTTCTAATCCATCAGCTGGAGATACAA
CAGACTCAAGCAGTCATACCGAATTAGGTCAAAATGACGCTGTTATAACACCGTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-232)

PASTA domain (PASTA)

(372-434)

PASTA domain (PASTA)

(441-506)

PASTA domain (PASTA)

(512-588)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.546

94.295

0.618
  stkP/pknB Streptococcus salivarius strain HSISS4

62.415

93.185

0.582
  stkP Streptococcus pneumoniae TIGR4

59.302

81.775

0.485
  stkP Streptococcus pneumoniae D39

58.915

81.775

0.482
  stkP Streptococcus pneumoniae R6

58.915

81.775

0.482
  stkP Streptococcus pneumoniae Rx1

58.721

81.775

0.48

Multiple sequence alignment