Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   FGK81_RS08185 Genome accession   NZ_LR590466
Coordinates   1593435..1594196 (-) Length   253 a.a.
NCBI ID   WP_002986029.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8193     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1588435..1599196
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGK81_RS08165 (NCTC8193_01620) - 1588753..1589979 (-) 1227 WP_002986020.1 cysteine desulfurase -
  FGK81_RS08170 (NCTC8193_01621) sufD 1590010..1591272 (-) 1263 WP_011054182.1 Fe-S cluster assembly protein SufD -
  FGK81_RS08175 (NCTC8193_01622) sufC 1591367..1592137 (-) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  FGK81_RS08180 (NCTC8193_01623) - 1592259..1593428 (-) 1170 WP_011888595.1 glycosyltransferase family 4 protein -
  FGK81_RS08185 (NCTC8193_01624) mecA 1593435..1594196 (-) 762 WP_002986029.1 adaptor protein MecA Regulator
  FGK81_RS08190 (NCTC8193_01625) - 1594342..1595181 (-) 840 WP_011888594.1 undecaprenyl-diphosphate phosphatase -
  FGK81_RS08195 (NCTC8193_01626) - 1595247..1597172 (-) 1926 WP_011888593.1 DUF2207 domain-containing protein -
  FGK81_RS08200 (NCTC8193_01627) - 1597370..1598938 (+) 1569 WP_002991130.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.72 Da        Isoelectric Point: 4.1622

>NTDB_id=1126802 FGK81_RS08185 WP_002986029.1 1593435..1594196(-) (mecA) [Streptococcus pyogenes strain NCTC8193]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=1126802 FGK81_RS08185 WP_002986029.1 1593435..1594196(-) (mecA) [Streptococcus pyogenes strain NCTC8193]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486

Multiple sequence alignment