Detailed information NTG1126762

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: FGK81_RS00155
• Genome accession: NZ_LR590466
• Coordinates: 27168..28391 (-)
• Length: 407 a.a.
• NCBI ID: WP_002981947.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8193
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 22168..33391

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGK81_RS00135 (NCTC8193_00027)	-	23182..23379 (-)	198	WP_002981933.1	DUF951 domain-containing protein	-
FGK81_RS00140 (NCTC8193_00028)	dnaN	23454..24590 (-)	1137	WP_011184038.1	DNA polymerase III subunit beta	-
FGK81_RS00145 (NCTC8193_00029)	dnaA	24745..26100 (-)	1356	WP_002987659.1	chromosomal replication initiator protein DnaA	-
FGK81_RS00150 (NCTC8193_00030)	spo0J	26303..27079 (-)	777	WP_002981939.1	ParB/RepB/Spo0J family partition protein	Regulator
FGK81_RS00155 (NCTC8193_00031)	htrA	27168..28391 (-)	1224	WP_002981947.1	S1C family serine protease	Regulator
FGK81_RS00160 (NCTC8193_00032)	rlmH	28603..29082 (+)	480	WP_011889262.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FGK81_RS00170 (NCTC8193_00034)	-	29498..30596 (+)	1099	Protein_17	IS30 family transposase	-

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42758.40 Da
• Isoelectric Point: 7.3920

>NTDB_id=1126762 FGK81_RS00155 WP_002981947.1 27168..28391(-) (htrA) [Streptococcus pyogenes strain NCTC8193]
MPSMKHILKSLSVLLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKIVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=1126762 FGK81_RS00155 WP_002981947.1 27168..28391(-) (htrA) [Streptococcus pyogenes strain NCTC8193]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTGTTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTTAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGATTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATCAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAATAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (301-396)

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.634	99.263	0.612
htrA	Streptococcus gordonii str. Challis substr. CH1	55.473	98.771	0.548
htrA	Streptococcus mitis NCTC 12261	53.317	100	0.533
htrA	Streptococcus pneumoniae Rx1	53.071	100	0.531
htrA	Streptococcus pneumoniae D39	53.071	100	0.531
htrA	Streptococcus pneumoniae R6	53.071	100	0.531
htrA	Streptococcus pneumoniae TIGR4	53.071	100	0.531