Detailed information NTG1126554

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: E0F34_RS06090
• Genome accession: NZ_LR536843
• Coordinates: 1115260..1115997 (-)
• Length: 245 a.a.
• NCBI ID: WP_000782676.1
• Uniprot ID: A0A064C3U8
• Organism: Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8
• Function: degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 1110260..1120997

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F34_RS06070 (SAMEA104035599_01151)	msrB	1111719..1112657 (-)	939	WP_000818203.1	peptide-methionine (R)-S-oxide reductase MsrB	-
E0F34_RS11910	-	1112724..1112876 (-)	153	WP_001835993.1	hypothetical protein	-
E0F34_RS06080 (SAMEA104035599_01152)	thrB	1112952..1113821 (-)	870	WP_000692438.1	homoserine kinase	-
E0F34_RS06085 (SAMEA104035599_01153)	-	1113823..1115109 (-)	1287	WP_000216383.1	homoserine dehydrogenase	-
E0F34_RS06090 (SAMEA104035599_01154)	mecA	1115260..1115997 (-)	738	WP_000782676.1	adaptor protein MecA	Regulator
E0F34_RS06095 (SAMEA104035599_01155)	-	1116197..1117231 (-)	1035	WP_000461498.1	hypothetical protein	-
E0F34_RS06100 (SAMEA104035599_01156)	-	1117260..1118696 (-)	1437	WP_000565075.1	O-antigen polysaccharide polymerase Wzy family protein	-
E0F34_RS06105 (SAMEA104035599_01157)	-	1118712..1119698 (-)	987	WP_000446988.1	glycosyltransferase family 2 protein	-
E0F34_RS06110 (SAMEA104035599_01158)	-	1119700..1120803 (-)	1104	WP_000225891.1	glycosyltransferase	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28381.18 Da
• Isoelectric Point: 4.0199

>NTDB_id=1126554 E0F34_RS06090 WP_000782676.1 1115260..1115997(-) (mecA) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide

• Length: 738 bp

>NTDB_id=1126554 E0F34_RS06090 WP_000782676.1 1115260..1115997(-) (mecA) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-239)

3D structure

• AlphaFold DB: A0A064C3U8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus pneumoniae Rx1	99.592	100	0.996
mecA	Streptococcus pneumoniae D39	99.592	100	0.996
mecA	Streptococcus pneumoniae R6	99.592	100	0.996
mecA	Streptococcus pneumoniae TIGR4	99.184	100	0.992
mecA	Streptococcus thermophilus LMD-9	47.791	100	0.486
mecA	Streptococcus thermophilus LMG 18311	47.39	100	0.482
mecA	Streptococcus mutans UA159	48.163	100	0.482