Detailed information NTG1126175

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: E0F39_RS02790
• Genome accession: NZ_LR216060
• Coordinates: 511866..512603 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219137.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain GPSC47 substr. ST315
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 506866..517603

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F39_RS12200	-	507797..508036 (-)	240	WP_001813906.1	hypothetical protein	-
E0F39_RS02760 (SAMEA3713867_00514)	-	508198..508485 (-)	288	WP_000777760.1	hypothetical protein	-
E0F39_RS02765 (SAMEA3713867_00515)	-	508495..508905 (-)	411	WP_001278301.1	HIT family protein	-
E0F39_RS02770 (SAMEA3713867_00516)	pptA	508973..509704 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
E0F39_RS02775 (SAMEA3713867_00517)	-	509701..510750 (+)	1050	WP_000653751.1	ABC transporter permease	-
E0F39_RS02780 (SAMEA3713867_00518)	-	510918..511247 (-)	330	WP_000132572.1	hypothetical protein	-
E0F39_RS02785 (SAMEA3713867_00519)	-	511523..511861 (+)	339	WP_000682133.1	LytTR family DNA-binding domain-containing protein	-
E0F39_RS02790 (SAMEA3713867_00520)	comE/blpR	511866..512603 (+)	738	WP_001219137.1	response regulator transcription factor	Regulator
E0F39_RS02795 (SAMEA3713867_00521)	-	512617..513957 (+)	1341	WP_001099893.1	sensor histidine kinase	-
E0F39_RS02800 (SAMEA3713867_00522)	blpC	514001..514156 (-)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
E0F39_RS02805 (SAMEA3713867_00523)	-	514213..514935 (-)	723	Protein_534	HlyD family efflux transporter periplasmic adaptor subunit	-
E0F39_RS02815	-	515044..515142 (+)	99	Protein_535	IS5/IS1182 family transposase	-
E0F39_RS02820 (SAMEA3713867_00524)	-	515160..515798 (-)	639	Protein_536	bacteriocin ABC transporter ATP-binding protein	-
E0F39_RS02825 (SAMEA3713867_00525)	comA/nlmT	515809..517485 (-)	1677	WP_306293384.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28768.92 Da
• Isoelectric Point: 6.2366

>NTDB_id=1126175 E0F39_RS02790 WP_001219137.1 511866..512603(+) (comE/blpR) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1126175 E0F39_RS02790 WP_001219137.1 511866..512603(+) (comE/blpR) [Streptococcus pneumoniae strain GPSC47 substr. ST315]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.441	100	0.539
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38