Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   E0F32_RS06635 Genome accession   NZ_LR216050
Coordinates   1245356..1246093 (-) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   A0A064C3U8
Organism   Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1240356..1251093
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F32_RS06615 (SAMEA3431333_01240) msrB 1241815..1242753 (-) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -
  E0F32_RS11950 (SAMEA3431333_01241) - 1242820..1242972 (-) 153 WP_050117946.1 hypothetical protein -
  E0F32_RS06625 (SAMEA3431333_01242) thrB 1243048..1243917 (-) 870 WP_000692438.1 homoserine kinase -
  E0F32_RS06630 (SAMEA3431333_01243) - 1243919..1245205 (-) 1287 WP_050117936.1 homoserine dehydrogenase -
  E0F32_RS06635 (SAMEA3431333_01244) mecA 1245356..1246093 (-) 738 WP_000782676.1 adaptor protein MecA Regulator
  E0F32_RS06640 (SAMEA3431333_01245) - 1246293..1247327 (-) 1035 WP_000461501.1 hypothetical protein -
  E0F32_RS06645 (SAMEA3431333_01246) - 1247356..1248789 (-) 1434 WP_000565082.1 O-antigen polysaccharide polymerase Wzy family protein -
  E0F32_RS06650 (SAMEA3431333_01247) - 1248805..1249791 (-) 987 WP_000446969.1 glycosyltransferase family 2 protein -
  E0F32_RS06655 (SAMEA3431333_01248) - 1249793..1250896 (-) 1104 WP_000225894.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=1126116 E0F32_RS06635 WP_000782676.1 1245356..1246093(-) (mecA) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1126116 E0F32_RS06635 WP_000782676.1 1245356..1246093(-) (mecA) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAAGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064C3U8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment