Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EQB55_RS01250 Genome accession   NZ_LR135482
Coordinates   240916..242205 (-) Length   429 a.a.
NCBI ID   WP_002331193.1    Uniprot ID   A0A829FMH0
Organism   Enterococcus faecium isolate E4456     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 235916..247205
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB55_RS01220 - 236319..237266 (-) 948 WP_002331190.1 glycosyltransferase family 2 protein -
  EQB55_RS01225 - 237489..237839 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  EQB55_RS01230 pepA 238039..239118 (+) 1080 WP_002331191.1 glutamyl aminopeptidase -
  EQB55_RS01235 - 239261..239581 (+) 321 WP_002287837.1 thioredoxin family protein -
  EQB55_RS01240 - 239603..240067 (+) 465 WP_002331192.1 universal stress protein -
  EQB55_RS01245 ytpR 240272..240877 (+) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  EQB55_RS01250 htrA 240916..242205 (-) 1290 WP_002331193.1 S1C family serine protease Regulator
  EQB55_RS01255 rlmH 242633..243112 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQB55_RS01260 - 243197..243705 (+) 509 Protein_242 DUF1456 family protein -
  EQB55_RS01265 - 243805..244455 (+) 651 WP_002296570.1 hypothetical protein -
  EQB55_RS01270 - 244906..245844 (+) 939 WP_002291914.1 2-dehydropantoate 2-reductase -
  EQB55_RS01275 - 245857..246909 (+) 1053 WP_002291912.1 PTS sugar transporter subunit IIC -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44973.96 Da        Isoelectric Point: 4.5058

>NTDB_id=1125694 EQB55_RS01250 WP_002331193.1 240916..242205(-) (htrA) [Enterococcus faecium isolate E4456]
MDRKNVTPKMKKSKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTTSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGELFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=1125694 EQB55_RS01250 WP_002331193.1 240916..242205(-) (htrA) [Enterococcus faecium isolate E4456]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAGTAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGAACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCTGTCTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCAGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(317-414)

Peptidase family M50 (Peptidase_M50)

(9-417)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A829FMH0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.027

96.27

0.51
  htrA Streptococcus mutans UA159

59.887

82.517

0.494
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464

Multiple sequence alignment