Detailed information
Bioinformatically predicted
Overview
| Name | htrA | Type | Regulator |
| Locus tag | EQB52_RS02060 | Genome accession | NZ_LR135475 |
| Coordinates | 408624..409913 (+) | Length | 429 a.a. |
| NCBI ID | WP_002290101.1 | Uniprot ID | A0A828ZUK2 |
| Organism | Enterococcus faecium isolate E8423 | ||
| Function | repress competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 334014..423147 | 408624..409913 | within | 0 |
Gene organization within MGE regions
Location: 334014..423147
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EQB52_RS01670 | - | 334530..335663 (+) | 1134 | WP_002287572.1 | alcohol dehydrogenase catalytic domain-containing protein | - |
| EQB52_RS01675 | - | 335694..336014 (+) | 321 | WP_002287574.1 | YrhK family protein | - |
| EQB52_RS01680 | - | 336043..336507 (-) | 465 | WP_002287575.1 | GNAT family N-acetyltransferase | - |
| EQB52_RS01685 | - | 336638..337891 (-) | 1254 | WP_002287577.1 | PTS sugar transporter subunit IIC | - |
| EQB52_RS01690 | - | 337920..338237 (-) | 318 | WP_002287579.1 | PTS lactose/cellobiose transporter subunit IIA | - |
| EQB52_RS01695 | - | 338263..338583 (-) | 321 | WP_002287582.1 | PTS sugar transporter subunit IIB | - |
| EQB52_RS01700 | - | 339047..340462 (-) | 1416 | WP_002287583.1 | glycoside hydrolase family 1 protein | - |
| EQB52_RS01705 | - | 340479..341795 (-) | 1317 | WP_002287584.1 | PTS sugar transporter subunit IIC | - |
| EQB52_RS01710 | - | 341945..342643 (-) | 699 | WP_002287585.1 | FadR/GntR family transcriptional regulator | - |
| EQB52_RS01715 | - | 342932..343892 (-) | 961 | Protein_304 | aldo/keto reductase | - |
| EQB52_RS01720 | msrA | 344006..344839 (-) | 834 | WP_002300896.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| EQB52_RS01725 | truA | 345073..345816 (-) | 744 | WP_002300898.1 | tRNA pseudouridine(38-40) synthase TruA | - |
| EQB52_RS01730 | - | 346007..346642 (-) | 636 | WP_002294730.1 | DUF998 domain-containing protein | - |
| EQB52_RS01735 | sstT | 346789..348009 (-) | 1221 | WP_002352746.1 | serine/threonine transporter SstT | - |
| EQB52_RS01740 | - | 348351..349028 (-) | 678 | WP_025477866.1 | DUF4767 domain-containing protein | - |
| EQB52_RS01745 | - | 349279..349821 (-) | 543 | WP_002300904.1 | ferritin-like domain-containing protein | - |
| EQB52_RS01750 | - | 349826..350053 (-) | 228 | WP_002300905.1 | heavy-metal-associated domain-containing protein | - |
| EQB52_RS01755 | - | 350132..352012 (-) | 1881 | WP_002300907.1 | heavy metal translocating P-type ATPase | - |
| EQB52_RS01760 | - | 352313..352633 (+) | 321 | WP_002330723.1 | PRD domain-containing protein | - |
| EQB52_RS01765 | - | 352712..353890 (-) | 1179 | WP_000997695.1 | IS256-like element ISEf1 family transposase | - |
| EQB52_RS01770 | - | 354127..355086 (+) | 960 | WP_127824083.1 | IS30-like element IS6770 family transposase | - |
| EQB52_RS01775 | - | 355245..355721 (-) | 477 | WP_002300328.1 | PTS glucose transporter subunit IIA | - |
| EQB52_RS01780 | - | 355734..357236 (-) | 1503 | WP_002289252.1 | PTS transporter subunit EIIC | - |
| EQB52_RS01785 | - | 357250..357939 (-) | 690 | WP_002289253.1 | N-acetylmannosamine-6-phosphate 2-epimerase | - |
| EQB52_RS01790 | - | 358100..358918 (+) | 819 | WP_002289254.1 | MurR/RpiR family transcriptional regulator | - |
| EQB52_RS01795 | - | 359148..359378 (+) | 231 | WP_002289255.1 | resolvase | - |
| EQB52_RS01800 | - | 359601..359699 (-) | 99 | Protein_321 | IS30 family transposase | - |
| EQB52_RS01810 | - | 359965..361304 (+) | 1340 | WP_086953915.1 | IS3-like element ISEnfa3 family transposase | - |
| EQB52_RS01815 | - | 361328..361600 (+) | 273 | Protein_323 | DDE-type integrase/transposase/recombinase | - |
| EQB52_RS01820 | - | 361652..362098 (-) | 447 | Protein_324 | DUF998 domain-containing protein | - |
| EQB52_RS01825 | - | 362156..363208 (-) | 1053 | WP_002291912.1 | PTS sugar transporter subunit IIC | - |
| EQB52_RS01830 | - | 363221..364159 (-) | 939 | WP_002291914.1 | 2-dehydropantoate 2-reductase | - |
| EQB52_RS01835 | - | 364610..365260 (-) | 651 | WP_002298023.1 | hypothetical protein | - |
| EQB52_RS01840 | - | 365360..365869 (-) | 510 | WP_002301781.1 | DUF1456 family protein | - |
| EQB52_RS01850 | - | 366232..366615 (-) | 384 | WP_002331215.1 | GntR family transcriptional regulator | - |
| EQB52_RS01855 | - | 366856..367470 (-) | 615 | WP_002336652.1 | GNAT family N-acetyltransferase | - |
| EQB52_RS01860 | - | 367614..368175 (+) | 562 | Protein_331 | TetR/AcrR family transcriptional regulator | - |
| EQB52_RS01865 | lacD | 368286..369260 (-) | 975 | WP_002336651.1 | tagatose-bisphosphate aldolase | - |
| EQB52_RS01870 | - | 369279..369734 (-) | 456 | WP_002336650.1 | fructose PTS transporter subunit IIA | - |
| EQB52_RS01875 | - | 369762..371207 (-) | 1446 | WP_002336649.1 | PTS fructose transporter subunit IIC | - |
| EQB52_RS01880 | pfkB | 371204..372139 (-) | 936 | WP_002331209.1 | 1-phosphofructokinase | - |
| EQB52_RS01885 | - | 372307..373065 (+) | 759 | WP_002331208.1 | MurR/RpiR family transcriptional regulator | - |
| EQB52_RS01890 | - | 373560..374759 (-) | 1200 | WP_002345001.1 | MFS transporter | - |
| EQB52_RS01895 | - | 375202..375693 (-) | 492 | WP_002331206.1 | hypothetical protein | - |
| EQB52_RS01900 | dgoD | 375720..376865 (-) | 1146 | WP_002331205.1 | galactonate dehydratase | - |
| EQB52_RS01905 | - | 376880..378247 (-) | 1368 | WP_002336647.1 | PTS galactitol transporter subunit IIC | - |
| EQB52_RS01910 | - | 378272..378550 (-) | 279 | WP_002331203.1 | PTS sugar transporter subunit IIB | - |
| EQB52_RS01915 | - | 378569..379027 (-) | 459 | WP_002336646.1 | PTS sugar transporter subunit IIA | - |
| EQB52_RS01920 | - | 379039..379659 (-) | 621 | WP_002336645.1 | bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase | - |
| EQB52_RS01925 | - | 379670..381712 (-) | 2043 | WP_002336644.1 | BglG family transcription antiterminator | - |
| EQB52_RS01930 | - | 381997..382677 (+) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| EQB52_RS01935 | ermCL | 382779..382838 (+) | 60 | WP_002503927.1 | 23S rRNA methylase leader peptide ErmCL | - |
| EQB52_RS01940 | - | 382888..383622 (+) | 735 | WP_002345002.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(T) | - |
| EQB52_RS01945 | - | 384374..385054 (+) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| EQB52_RS01950 | - | 385077..385964 (-) | 888 | WP_025479406.1 | protein rep | - |
| EQB52_RS01955 | mobV | 386209..387471 (-) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| EQB52_RS01965 | tet(L) | 388035..389408 (-) | 1374 | WP_060806738.1 | tetracycline efflux MFS transporter Tet(L) | - |
| EQB52_RS01970 | tet(M) | 389506..391425 (-) | 1920 | WP_002345005.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| EQB52_RS16135 | - | 391441..391488 (-) | 48 | Protein_353 | hypothetical protein | - |
| EQB52_RS01980 | - | 391802..392716 (-) | 915 | WP_002345006.1 | conjugal transfer protein | - |
| EQB52_RS01985 | - | 392731..393732 (-) | 1002 | WP_002345007.1 | lysozyme family protein | - |
| EQB52_RS01990 | - | 393729..395912 (-) | 2184 | WP_002345008.1 | CD3337/EF1877 family mobilome membrane protein | - |
| EQB52_RS01995 | - | 395915..398362 (-) | 2448 | WP_000331148.1 | ATP-binding protein | - |
| EQB52_RS02000 | - | 398346..398738 (-) | 393 | WP_002345009.1 | conjugal transfer protein | - |
| EQB52_RS02005 | - | 398825..399322 (-) | 498 | WP_002345010.1 | antirestriction protein ArdA | - |
| EQB52_RS02010 | - | 399439..399663 (-) | 225 | WP_032509114.1 | hypothetical protein | - |
| EQB52_RS02015 | ltrA | 399767..401677 (-) | 1911 | WP_002286940.1 | group II intron reverse transcriptase/maturase | - |
| EQB52_RS02020 | mobT | 402461..403666 (-) | 1206 | WP_000398284.1 | MobT family relaxase | - |
| EQB52_RS02025 | - | 403689..403842 (-) | 154 | Protein_363 | conjugal transfer protein | - |
| EQB52_RS02030 | - | 403845..405230 (-) | 1386 | WP_000813488.1 | FtsK/SpoIIIE domain-containing protein | - |
| EQB52_RS02035 | - | 405259..405645 (-) | 387 | WP_000985015.1 | YdcP family protein | - |
| EQB52_RS02040 | - | 405661..405975 (-) | 315 | WP_000420682.1 | YdcP family protein | - |
| EQB52_RS02050 | rlmH | 406328..406807 (-) | 480 | WP_002345011.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| EQB52_RS02055 | - | 407301..408380 (-) | 1080 | WP_002326691.1 | IS30 family transposase | - |
| EQB52_RS02060 | htrA | 408624..409913 (+) | 1290 | WP_002290101.1 | S1C family serine protease | Regulator |
| EQB52_RS02065 | ytpR | 409952..410557 (-) | 606 | WP_002313997.1 | YtpR family tRNA-binding protein | - |
| EQB52_RS02075 | - | 410753..411217 (-) | 465 | WP_002345012.1 | universal stress protein | - |
| EQB52_RS02080 | - | 411239..411559 (-) | 321 | WP_002292632.1 | thioredoxin family protein | - |
| EQB52_RS02085 | pepA | 411702..412781 (-) | 1080 | WP_002294156.1 | glutamyl aminopeptidase | - |
| EQB52_RS02090 | - | 412981..413331 (+) | 351 | WP_002309710.1 | PepSY domain-containing protein | - |
| EQB52_RS02095 | - | 413516..414469 (+) | 954 | WP_002299300.1 | glycosyltransferase family 2 protein | - |
| EQB52_RS02100 | - | 414482..416269 (+) | 1788 | WP_002299301.1 | DUF6020 family protein | - |
| EQB52_RS02105 | - | 416256..417458 (+) | 1203 | WP_002299302.1 | hypothetical protein | - |
| EQB52_RS02115 | - | 417663..418958 (+) | 1296 | WP_002297218.1 | ISL3-like element ISEfa11 family transposase | - |
| EQB52_RS02120 | pepV | 419056..420474 (-) | 1419 | WP_127824084.1 | dipeptidase PepV | - |
| EQB52_RS02125 | - | 420623..421468 (+) | 846 | WP_002299303.1 | NAD(P)H-hydrate dehydratase | - |
| EQB52_RS02130 | - | 421472..421912 (+) | 441 | WP_002301667.1 | acyl-CoA thioesterase | - |
| EQB52_RS02135 | - | 421962..422156 (+) | 195 | WP_002315615.1 | hypothetical protein | - |
| EQB52_RS02140 | - | 422292..422977 (+) | 686 | Protein_383 | GntR family transcriptional regulator | - |
Sequence
Protein
Download Length: 429 a.a. Molecular weight: 44916.93 Da Isoelectric Point: 4.5419
>NTDB_id=1125655 EQB52_RS02060 WP_002290101.1 408624..409913(+) (htrA) [Enterococcus faecium isolate E8423]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN
Nucleotide
Download Length: 1290 bp
>NTDB_id=1125655 EQB52_RS02060 WP_002290101.1 408624..409913(+) (htrA) [Enterococcus faecium isolate E8423]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTAATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAATCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCCTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACGGTTGCCTCTTTTGGGGACTCAAGTGCTTTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCCATCCCAAGTAACGATGTAGTGAATATCATCAACCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCAGAAAAAGCTGGGTTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTAATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAATCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCCTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACGGTTGCCTCTTTTGGGGACTCAAGTGCTTTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCCATCCCAAGTAACGATGTAGTGAATATCATCAACCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCAGAAAAAGCTGGGTTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| htrA | Streptococcus gordonii str. Challis substr. CH1 |
54.569 |
91.841 |
0.501 |
| htrA | Streptococcus mutans UA159 |
60.169 |
82.517 |
0.496 |
| htrA | Streptococcus mitis NCTC 12261 |
52.778 |
92.308 |
0.487 |
| htrA | Streptococcus pneumoniae TIGR4 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae Rx1 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae D39 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae R6 |
59.05 |
78.555 |
0.464 |