Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EQB53_RS01260 Genome accession   NZ_LR135428
Coordinates   243344..244633 (-) Length   429 a.a.
NCBI ID   WP_002319485.1    Uniprot ID   -
Organism   Enterococcus faecium isolate E8927     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 238344..249633
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB53_RS01230 - 238746..239693 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  EQB53_RS01235 - 239916..240266 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  EQB53_RS01240 pepA 240466..241545 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  EQB53_RS01245 - 241689..242009 (+) 321 WP_002287837.1 thioredoxin family protein -
  EQB53_RS01250 - 242031..242495 (+) 465 WP_002287838.1 universal stress protein -
  EQB53_RS01255 ytpR 242700..243305 (+) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  EQB53_RS01260 htrA 243344..244633 (-) 1290 WP_002319485.1 S1C family serine protease Regulator
  EQB53_RS01265 rlmH 245061..245540 (+) 480 WP_002345011.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQB53_RS01275 - 245893..246207 (+) 315 WP_000420682.1 YdcP family protein -
  EQB53_RS01280 - 246223..246609 (+) 387 WP_000985015.1 YdcP family protein -
  EQB53_RS01285 - 246638..248023 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  EQB53_RS01290 - 248026..248179 (+) 154 Protein_243 conjugal transfer protein -
  EQB53_RS01295 mobT 248202..249407 (+) 1206 WP_000398284.1 MobT family relaxase -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44898.89 Da        Isoelectric Point: 4.5419

>NTDB_id=1125508 EQB53_RS01260 WP_002319485.1 243344..244633(-) (htrA) [Enterococcus faecium isolate E8927]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=1125508 EQB53_RS01260 WP_002319485.1 243344..244633(-) (htrA) [Enterococcus faecium isolate E8927]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

PDZ domain (PDZ_2)

(317-414)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.569

91.841

0.501
  htrA Streptococcus mutans UA159

59.887

82.517

0.494
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464

Multiple sequence alignment