Detailed information NTG1124588

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EQB63_RS01200
• Genome accession: NZ_LR135235
• Coordinates: 231361..232650 (-)
• Length: 429 a.a.
• NCBI ID: WP_002319485.1
• Uniprot ID: -
• Organism: Enterococcus faecium isolate E7067
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	229940..235980	231361..232650	within	0

Gene organization within MGE regions

Location: 229940..235980

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQB63_RS01195	-	229940..231235 (+)	1296	WP_002297218.1	ISL3-like element ISEfa11 family transposase	-
EQB63_RS01200	htrA	231361..232650 (-)	1290	WP_002319485.1	S1C family serine protease	Regulator
EQB63_RS01205	rlmH	233079..233558 (+)	480	WP_002287841.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQB63_RS01210	-	233684..234637 (+)	954	WP_010731142.1	IS30 family transposase	-
EQB63_RS01215	-	234805..235266 (+)	462	WP_232019563.1	helix-turn-helix domain-containing protein	-
EQB63_RS01220	-	235300..235980 (-)	681	WP_001015311.1	IS6-like element IS1216 family transposase	-

Sequence

Protein

• Length: 429 a.a.
• Molecular weight: 44898.89 Da
• Isoelectric Point: 4.5419

>NTDB_id=1124588 EQB63_RS01200 WP_002319485.1 231361..232650(-) (htrA) [Enterococcus faecium isolate E7067]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide

• Length: 1290 bp

>NTDB_id=1124588 EQB63_RS01200 WP_002319485.1 231361..232650(-) (htrA) [Enterococcus faecium isolate E7067]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (10-417)

• PDZ domain (PDZ_2) (317-414)

• Trypsin-like peptidase domain (Trypsin_2) (127-272)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	54.569	91.841	0.501
htrA	Streptococcus mutans UA159	59.887	82.517	0.494
htrA	Streptococcus mitis NCTC 12261	52.778	92.308	0.487
htrA	Streptococcus pneumoniae TIGR4	59.05	78.555	0.464
htrA	Streptococcus pneumoniae Rx1	59.05	78.555	0.464
htrA	Streptococcus pneumoniae D39	59.05	78.555	0.464
htrA	Streptococcus pneumoniae R6	59.05	78.555	0.464