Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EL345_RS01235 Genome accession   NZ_LR135170
Coordinates   232278..233561 (-) Length   427 a.a.
NCBI ID   WP_002324312.1    Uniprot ID   A0AB37VT26
Organism   Enterococcus faecium isolate E4227     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 227278..238561
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL345_RS01205 - 227437..228393 (-) 957 WP_002317103.1 glycosyltransferase family 2 protein -
  EL345_RS01210 - 228565..228918 (-) 354 WP_002317104.1 PepSY domain-containing protein -
  EL345_RS01215 pepA 229117..230196 (+) 1080 WP_002317105.1 glutamyl aminopeptidase -
  EL345_RS01220 - 230488..230808 (+) 321 WP_002317106.1 thioredoxin family protein -
  EL345_RS01225 - 230838..231305 (+) 468 WP_002317107.1 universal stress protein -
  EL345_RS01230 ytpR 231615..232220 (+) 606 WP_002317108.1 YtpR family tRNA-binding protein -
  EL345_RS01235 htrA 232278..233561 (-) 1284 WP_002324312.1 S1C family serine protease Regulator
  EL345_RS01240 rlmH 234014..234493 (+) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EL345_RS01250 - 236241..237371 (+) 1131 WP_002317111.1 hypothetical protein -
  EL345_RS01255 - 237539..238447 (+) 909 WP_010778368.1 IS982-like element ISEfm1 family transposase -

Sequence

Protein


Download         Length: 427 a.a.        Molecular weight: 44453.55 Da        Isoelectric Point: 4.7976

>NTDB_id=1124255 EL345_RS01235 WP_002324312.1 232278..233561(-) (htrA) [Enterococcus faecium isolate E4227]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTKV
KAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVNI
NAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITMV
DLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYRG
KEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1284 bp        

>NTDB_id=1124255 EL345_RS01235 WP_002324312.1 232278..233561(-) (htrA) [Enterococcus faecium isolate E4227]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATCACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGTCAACTATTTGGCCA
ACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTAATT
CCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAAGTC
AAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGTTGC
TTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATGCCA
ACTCTGTGACTTCGGGGATCATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAATATC
AATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGACAAGTGATCGG
GATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCCCAA
GTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATGGTT
GACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGTTAC
TAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTGATG
TTTCTTCTGGTGTAGAATTACAATCTGTCTTATATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGCGGA
AAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGTCAATCAGAGAACTCTGGTAA
CTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(123-268)

PDZ domain (PDZ_2)

(313-410)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.483

94.145

0.504
  htrA Streptococcus mutans UA159

54.177

92.506

0.501
  htrA Streptococcus pneumoniae D39

58.631

78.689

0.461
  htrA Streptococcus pneumoniae TIGR4

58.631

78.689

0.461
  htrA Streptococcus pneumoniae R6

58.631

78.689

0.461
  htrA Streptococcus pneumoniae Rx1

58.631

78.689

0.461
  htrA Streptococcus mitis NCTC 12261

57.738

78.689

0.454

Multiple sequence alignment