Detailed information NTG1123646

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EL254_RS10550
• Genome accession: NZ_LR134512
• Coordinates: 2030568..2031797 (+)
• Length: 409 a.a.
• NCBI ID: WP_000728357.1
• Uniprot ID: A0AAD2WWM9
• Organism: Streptococcus agalactiae strain NCTC13949
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2025568..2036797

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL254_RS10525 (NCTC13949_02075)	-	2026730..2029309 (+)	2580	WP_000154429.1	YfhO family protein	-
EL254_RS10545 (NCTC13949_02079)	rlmH	2029888..2030367 (-)	480	WP_000768333.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL254_RS10550 (NCTC13949_02080)	htrA	2030568..2031797 (+)	1230	WP_000728357.1	S1C family serine protease	Regulator
EL254_RS10555 (NCTC13949_02081)	spo0J	2031895..2032668 (+)	774	WP_000456084.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 43090.54 Da
• Isoelectric Point: 9.5271

>NTDB_id=1123646 EL254_RS10550 WP_000728357.1 2030568..2031797(+) (htrA) [Streptococcus agalactiae strain NCTC13949]
MKKKLVSSLLKCSLIIIVSFAGGAFASFVMNHNDNIPNGGVTKTSKVNYNNITPTTKAVKKVQNSVVSVINYKQQESRSD
LSDFYSHFFGNQGGNTDKGLQVYGEGSGVIYKKDGKNAYVVTNNHVIDGAKQIEIQLADGSKAVGKLVGSDTYSDLAVVK
IPSDKVSNIAEFADSSKLNIGETAIAIGSPLGTEYANSVTQGIVSSLKRTVTMTNEEGQTVSTNAIQTDAAINPGNSGGA
LINIEGQVIGINSSKISSTSNQTSGQSSGNSVEGMGFAIPSNDVVKIINQLESNGQVERPALGISMAGLSNLPSDVISKL
KIPSNVTNGIVVASIQSGMPAQGKLKKYDVITKVDDKEVASPSDLQSLLYGHQVGDSITVTFYRGENKQTVTIKLTKTSK
DLAKQRANN

Nucleotide

• Length: 1230 bp

>NTDB_id=1123646 EL254_RS10550 WP_000728357.1 2030568..2031797(+) (htrA) [Streptococcus agalactiae strain NCTC13949]
GTGAAAAAAAAATTAGTCTCATCACTTCTAAAGTGTTCTCTAATCATTATTGTTAGCTTTGCTGGTGGAGCATTTGCTAG
TTTTGTCATGAATCATAATGACAATATTCCAAATGGTGGTGTCACTAAAACTAGTAAAGTAAATTATAATAACATAACGC
CTACAACAAAAGCTGTTAAAAAGGTACAAAATAGTGTTGTTTCTGTTATCAATTATAAACAACAAGAGAGTCGTTCTGAC
CTATCAGACTTCTATAGTCATTTTTTTGGTAATCAGGGGGGCAACACTGATAAGGGCTTACAAGTTTACGGTGAAGGCTC
TGGAGTCATCTATAAAAAAGATGGTAAAAATGCCTATGTTGTCACTAATAACCACGTCATTGATGGGGCTAAACAAATTG
AAATTCAACTAGCCGATGGCTCAAAAGCAGTTGGGAAACTTGTTGGGTCAGATACCTACTCTGATTTAGCCGTCGTCAAA
ATTCCATCAGATAAAGTTTCAAATATTGCAGAATTTGCTGATTCATCAAAACTCAACATTGGTGAAACTGCTATAGCGAT
CGGAAGCCCTCTTGGAACTGAGTATGCAAATTCTGTAACTCAAGGTATTGTATCTAGTTTAAAAAGAACTGTAACAATGA
CTAATGAAGAAGGACAAACAGTTTCTACAAATGCTATCCAGACTGATGCTGCTATCAATCCTGGTAATTCAGGTGGAGCA
CTTATCAATATTGAAGGACAGGTTATTGGAATTAATTCTAGTAAAATTTCTTCTACATCAAATCAAACCTCAGGACAATC
GTCAGGAAATAGCGTTGAAGGTATGGGATTTGCCATTCCTTCAAATGATGTTGTTAAGATTATCAATCAACTTGAGAGTA
ACGGACAAGTAGAGAGACCTGCTCTAGGTATTTCTATGGCTGGATTAAGTAATTTACCATCCGATGTTATTAGTAAACTG
AAAATCCCAAGTAATGTTACTAATGGTATTGTAGTAGCATCTATCCAATCTGGCATGCCAGCTCAAGGCAAACTAAAGAA
ATACGATGTCATTACTAAAGTTGACGATAAAGAAGTAGCATCTCCAAGTGATTTACAAAGTTTACTCTATGGCCACCAGG
TAGGAGATTCCATAACAGTAACCTTTTATCGTGGTGAAAATAAACAAACAGTCACTATAAAACTTACTAAAACTAGTAAA
GATTTAGCTAAACAACGAGCAAATAACTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (106-251)

• PDZ domain (PDZ_2) (300-395)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	63.359	96.088	0.609
htrA	Streptococcus gordonii str. Challis substr. CH1	57.357	98.044	0.562
htrA	Streptococcus mitis NCTC 12261	56.533	97.311	0.55
htrA	Streptococcus pneumoniae TIGR4	55.037	99.511	0.548
htrA	Streptococcus pneumoniae Rx1	55.037	99.511	0.548
htrA	Streptococcus pneumoniae D39	55.037	99.511	0.548
htrA	Streptococcus pneumoniae R6	55.037	99.511	0.548