Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EL154_RS01135 Genome accession   NZ_LR134337
Coordinates   217563..218843 (-) Length   426 a.a.
NCBI ID   WP_071242877.1    Uniprot ID   -
Organism   Enterococcus faecium strain NCTC7174     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 212563..223843
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL154_RS01105 (NCTC7174_00215) - 212964..213911 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  EL154_RS01110 (NCTC7174_00216) - 214134..214484 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  EL154_RS01115 (NCTC7174_00217) pepA 214684..215763 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  EL154_RS01120 (NCTC7174_00218) - 215906..216226 (+) 321 WP_002287837.1 thioredoxin family protein -
  EL154_RS01125 (NCTC7174_00219) - 216248..216712 (+) 465 WP_002292633.1 universal stress protein -
  EL154_RS01130 (NCTC7174_00220) ytpR 216919..217524 (+) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  EL154_RS01135 (NCTC7174_00221) htrA 217563..218843 (-) 1281 WP_071242877.1 S1C family serine protease Regulator
  EL154_RS01140 (NCTC7174_00222) rlmH 219272..219751 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EL154_RS01145 (NCTC7174_00223) - 219954..220505 (+) 552 WP_002299296.1 PD-(D/E)XK nuclease family protein -
  EL154_RS01150 (NCTC7174_00224) - 220576..221745 (+) 1170 WP_002313998.1 IS256 family transposase -
  EL154_RS01155 (NCTC7174_00225) - 221855..223033 (-) 1179 WP_002330719.1 IS256-like element ISEfm2 family transposase -

Sequence

Protein


Download         Length: 426 a.a.        Molecular weight: 44576.53 Da        Isoelectric Point: 4.4821

>NTDB_id=1121885 EL154_RS01135 WP_071242877.1 217563..218843(-) (htrA) [Enterococcus faecium strain NCTC7174]
MDRKNVTPKMKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKAVDK
VQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDGTK
VKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNETVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKYGKVTRPALGITM
VDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITYYE
GSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1281 bp        

>NTDB_id=1121885 EL154_RS01135 WP_071242877.1 217563..218843(-) (htrA) [Enterococcus faecium strain NCTC7174]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGTTGGAGGGAT
CGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTACAAGCGGCA
ATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCGGTAGATAAA
GTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGGGCAGCA
AGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAAAAGACGGGA
ATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGACGGTACGAAG
GTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGTCGAAACAGT
TGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGATCTGAATATG
CAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAAACAGTCAAT
ATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGGACAAGTTAT
CGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGATTTGCTATTC
CAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAATACGGAAAAGTGACACGTCCAGCTCTAGGTATCACAATG
GTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGTCATCGT
GACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCGATGACAAAG
AAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTACTATGAA
GGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGAAAATTA
A

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(5-414)

Trypsin-like peptidase domain (Trypsin_2)

(124-269)

PDZ domain (PDZ_2)

(314-411)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.528

96.479

0.516
  htrA Streptococcus mutans UA159

59.887

83.099

0.498
  htrA Streptococcus mitis NCTC 12261

52.488

94.366

0.495
  htrA Streptococcus pneumoniae TIGR4

59.05

79.108

0.467
  htrA Streptococcus pneumoniae Rx1

59.05

79.108

0.467
  htrA Streptococcus pneumoniae D39

59.05

79.108

0.467
  htrA Streptococcus pneumoniae R6

59.05

79.108

0.467

Multiple sequence alignment