Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EL140_RS03685 Genome accession   NZ_LR134336
Coordinates   727326..728000 (+) Length   224 a.a.
NCBI ID   WP_000590630.1    Uniprot ID   A0A4V0BT06
Organism   Streptococcus oralis ATCC 35037 strain NCTC 11427     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 722326..733000
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL140_RS03665 (NCTC11427_00720) - 722785..723285 (+) 501 WP_000403333.1 NUDIX hydrolase -
  EL140_RS03670 (NCTC11427_00721) - 723263..724111 (+) 849 WP_001245872.1 putative PEP-binding protein -
  EL140_RS03675 (NCTC11427_00722) - 724108..724548 (+) 441 WP_000188823.1 ASCH domain-containing protein -
  EL140_RS03680 (NCTC11427_00723) - 724670..727216 (+) 2547 WP_001149145.1 M1 family metallopeptidase -
  EL140_RS03685 (NCTC11427_00724) ciaR 727326..728000 (+) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  EL140_RS03690 (NCTC11427_00725) ciaH 727990..729327 (+) 1338 WP_000482347.1 sensor histidine kinase Regulator
  EL140_RS03695 (NCTC11427_00726) - 729392..729676 (-) 285 WP_001276162.1 DUF3270 domain-containing protein -
  EL140_RS03700 (NCTC11427_00727) - 730063..731118 (+) 1056 WP_000280278.1 ABC transporter permease -
  EL140_RS03705 (NCTC11427_00728) - 731132..731812 (+) 681 WP_000209232.1 ABC transporter ATP-binding protein -
  EL140_RS03710 (NCTC11427_00729) - 731938..732867 (+) 930 WP_000411177.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25479.29 Da        Isoelectric Point: 4.2660

>NTDB_id=1121843 EL140_RS03685 WP_000590630.1 727326..728000(+) (ciaR) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1121843 EL140_RS03685 WP_000590630.1 727326..728000(+) (ciaR) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGTCTGTCAAACTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCAGAAAGTGGCGTTTATGACTTGATTTTGCTTGACCTGATGT
TGCCTGAAAAAAATGGTTTCCAAGTCTTGAAAGAATTGCGTGAGAAAGGAATCACGACACCAGTTCTTATCATGACTGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAACCTTTCTATCTAGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAATTTAACGAAAACACCTTAACCTATGGGGATATTGTCG
TCAACCTTTCAACGAATGAAGTGAAAGTGGAAGATACTCCTGTAGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAT
TTCCTTCAAAATCAAAATGTTATTCTTCCCAAGACGCAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.768

100

0.978
  ciaR Streptococcus pneumoniae D39

97.768

100

0.978
  ciaR Streptococcus pneumoniae R6

97.768

100

0.978
  ciaR Streptococcus pneumoniae Rx1

97.768

100

0.978
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment