Detailed information NTG1121842

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: EL140_RS03600
• Genome accession: NZ_LR134336
• Coordinates: 707450..709690 (+)
• Length: 746 a.a.
• NCBI ID: WP_000083028.1
• Uniprot ID: A0A7H9FC31
• Organism: Streptococcus oralis ATCC 35037 strain NCTC 11427
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 702450..714690

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL140_RS03565 (NCTC11427_00701)	-	702956..703561 (+)	606	WP_000727655.1	GrpB family protein	-
EL140_RS03570 (NCTC11427_00702)	-	703558..703773 (+)	216	WP_001232091.1	YozE family protein	-
EL140_RS03575 (NCTC11427_00703)	-	703854..704840 (+)	987	WP_000658168.1	PhoH family protein	-
EL140_RS03580 (NCTC11427_00704)	ald	704891..706003 (-)	1113	WP_000904713.1	alanine dehydrogenase	-
EL140_RS03590 (NCTC11427_00705)	-	706180..706749 (+)	570	WP_000443753.1	GNAT family N-acetyltransferase	-
EL140_RS03595 (NCTC11427_00706)	comEA/celA/cilE	706816..707466 (+)	651	WP_000452010.1	helix-hairpin-helix domain-containing protein	Machinery gene
EL140_RS03600 (NCTC11427_00707)	comEC/celB	707450..709690 (+)	2241	WP_000083028.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
EL140_RS03605	infC	709910..710440 (+)	531	WP_000848184.1	translation initiation factor IF-3	-
EL140_RS03610 (NCTC11427_00709)	rpmI	710473..710673 (+)	201	WP_001125942.1	50S ribosomal protein L35	-
EL140_RS03615 (NCTC11427_00710)	rplT	710725..711084 (+)	360	WP_000124830.1	50S ribosomal protein L20	-
EL140_RS03620 (NCTC11427_00711)	-	711258..712922 (+)	1665	WP_000635029.1	molecular chaperone HscC	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84710.83 Da
• Isoelectric Point: 8.6035

>NTDB_id=1121842 EL140_RS03600 WP_000083028.1 707450..709690(+) (comEC/celB) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
MSQRIKNFPIPLIYLSFLLLWLYFVILGASYLALLGFVFLLVCLFFQFPWKSAGKVLAICGVFGIWFLFQNWQQTQASQN
LVDSVERVRILPDTIKVNGDSLSFRGKAEGRTFQVYYKLQSEEEKELFQALTDLHEIELEGKLSEPEGQRNFGGFDYRAY
LKTQGIYQTLTIKSIQSLKQVSSWDIGENLSALRRKAVVWIKAHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDAFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFII
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVARESMVISLGILPILSFYFAEFQPWSILLTFVFSFLFDVVFLPLLSI
LFILSFVYPVTQFNFVFEWLECIIRLVSQLASRPLVFGQPNAWFLILLLVSLALVYDFRKNIKRIAGVILFIVGLFFLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESDKKIQAWQEKATTSNAQRTLIPYLKSRGVDKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLTQKDFVAELEASQTKVRSVTEGDNFSIFGSQLEVLSPRQIGDGDRDDSLVLYGKL
LDKHFLFTGNLEEKREKDLLKHYPDLEVDVLKASQHGAKTSSNPTFLEKIKPEITLISVGKNNRAKLPHQESLTRMESIK
SKIYRTDQQGAIRFTGWNSWRIETVR

Nucleotide

• Length: 2241 bp

>NTDB_id=1121842 EL140_RS03600 WP_000083028.1 707450..709690(+) (comEC/celB) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
ATGTCACAGCGGATTAAGAATTTCCCTATCCCCTTAATCTATCTGAGTTTTCTGTTACTCTGGCTTTACTTTGTCATTTT
AGGAGCGTCCTATCTCGCACTGCTAGGTTTTGTTTTTTTGCTGGTCTGCCTCTTTTTCCAATTTCCTTGGAAATCGGCTG
GTAAAGTTCTAGCGATTTGTGGAGTTTTTGGAATTTGGTTTTTGTTTCAAAACTGGCAACAGACACAAGCTAGTCAGAAC
CTAGTGGATTCTGTTGAAAGGGTACGGATTTTACCAGATACCATCAAAGTCAATGGAGACAGTCTGTCCTTTCGGGGCAA
GGCTGAGGGCCGCACCTTCCAAGTTTATTATAAACTCCAGTCCGAGGAAGAGAAAGAGCTCTTTCAGGCCTTAACAGACC
TTCACGAGATAGAGCTAGAAGGAAAACTTTCTGAGCCTGAAGGGCAGAGAAATTTTGGTGGATTTGACTACCGAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACACTGACTATCAAGAGCATCCAGTCACTTAAACAGGTTAGCAGTTGGGATATAGG
TGAAAATTTGTCGGCTTTACGTCGAAAGGCTGTAGTTTGGATCAAGGCGCACTTTCCAGACCCTATGCGCAACTATATGA
CAGGGCTTCTTTTAGGACATTTGGACACGGATTTTGAGGAGATGAATGAGCTTTATTCCAGTCTTGGAATTATCCATCTA
TTTGCCTTGTCAGGTATGCAAGTGGGCTTCTTTATGGATGCCTTTAAGAAACTCCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAGTGGCTAACTTATCCCTTTTCTCTTATCTATGCAGGTCTGACAGGATTTTCAGCATCTGTCATTCGCAGTC
TCTTGCAAAAGTTACTGGCCCAACATGGTGTTAAGGGTTTGGATAATTTTGCCTTGACGGTCCTTGTCCTCTTTATCATC
ATGCCCAACTTTTTCTTGACAGCTGGAGGGGTCTTGTCCTGCGCTTATGCTTTTATCTTGACTATGACAAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCCAGAGAAAGTATGGTCATTTCTTTGGGAATATTGCCCATTCTATCCTTTTATTTTGCAG
AATTTCAGCCTTGGTCTATCCTTTTGACCTTTGTTTTTTCCTTTCTGTTTGATGTGGTCTTCTTGCCACTTTTGTCCATC
TTATTCATTCTGTCTTTTGTTTACCCAGTCACTCAGTTTAACTTTGTCTTTGAGTGGTTGGAGTGTATCATTCGCTTGGT
ATCGCAGCTGGCAAGTAGGCCCCTGGTCTTTGGTCAACCCAATGCGTGGTTTTTGATTCTTCTCTTAGTTTCATTAGCTT
TAGTCTATGATTTTAGGAAAAATATTAAAAGAATAGCAGGAGTCATTCTCTTTATTGTGGGGCTCTTTTTCCTGACCAAG
CATCCACTTGAAAATGAAATTACCATGCTAGATGTTGGGCAAGGGGAGAGTATTTTCCTACGGGATGTAACTGGTAAAAC
TATTCTCATAGATGTAGGAGGTAAAGCAGAATCTGACAAGAAAATACAAGCTTGGCAGGAAAAGGCGACGACCAGCAATG
CCCAGAGAACTTTGATTCCCTATCTTAAAAGTCGAGGAGTAGATAAGATTGACCAGCTGATTTTGACCAATACAGACAAG
GAGCATGTTGGCGATTTGCTGGAGGTGACCAAGGCTTTCCATGTTGGAGAGATTTTAGTATCAAAAGGAAGTCTGACACA
GAAGGATTTTGTGGCAGAATTAGAAGCAAGTCAAACTAAGGTGCGCAGTGTGACAGAGGGGGATAATTTTTCGATTTTTG
GAAGTCAGTTAGAAGTCCTATCTCCAAGGCAGATTGGAGATGGGGATCGTGATGATTCTTTGGTTCTTTATGGAAAACTC
TTAGATAAGCACTTTCTCTTCACAGGAAATTTGGAGGAAAAAAGAGAGAAGGACTTGTTGAAGCATTATCCTGACCTAGA
GGTGGATGTCTTGAAAGCAAGCCAACATGGTGCTAAAACCTCATCAAATCCAACTTTCCTAGAAAAAATCAAACCAGAAA
TTACTCTCATCTCAGTTGGAAAAAACAATCGTGCGAAACTCCCCCATCAGGAATCCTTGACACGAATGGAAAGTATCAAG
AGTAAGATTTACAGAACTGACCAGCAAGGGGCTATCCGCTTTACAGGGTGGAATAGTTGGCGAATTGAAACGGTTCGATA
A

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (29-177)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-697)

• Competence protein (Competence) (216-457)

3D structure

• AlphaFold DB: A0A7H9FC31

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	87.534	100	0.875
comEC/celB	Streptococcus mitis NCTC 12261	87.651	99.866	0.875
comEC/celB	Streptococcus pneumoniae TIGR4	86.193	100	0.862
comEC/celB	Streptococcus pneumoniae Rx1	85.791	100	0.858
comEC/celB	Streptococcus pneumoniae D39	85.791	100	0.858
comEC/celB	Streptococcus pneumoniae R6	85.791	100	0.858
comEC	Lactococcus lactis subsp. cremoris KW2	45.209	99.33	0.449