Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   EL140_RS02025 Genome accession   NZ_LR134336
Coordinates   404716..406617 (+) Length   633 a.a.
NCBI ID   WP_000614521.1    Uniprot ID   A0A7H9FK75
Organism   Streptococcus oralis ATCC 35037 strain NCTC 11427     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 399716..411617
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL140_RS02010 (NCTC11427_00396) fmt 401722..402657 (+) 936 WP_000163670.1 methionyl-tRNA formyltransferase -
  EL140_RS02015 (NCTC11427_00397) rsmB 402650..403963 (+) 1314 WP_002874284.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  EL140_RS02020 (NCTC11427_00398) - 403979..404719 (+) 741 WP_000401527.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  EL140_RS02025 (NCTC11427_00399) stkP 404716..406617 (+) 1902 WP_000614521.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EL140_RS02030 (NCTC11427_00400) - 406704..407462 (+) 759 WP_000344539.1 threonine/serine exporter family protein -
  EL140_RS02035 (NCTC11427_00401) - 407464..407919 (+) 456 WP_000176902.1 threonine/serine exporter family protein -
  EL140_RS02040 (NCTC11427_00402) - 408038..409210 (+) 1173 WP_004181031.1 hydroxymethylglutaryl-CoA synthase -
  EL140_RS02045 (NCTC11427_00403) - 409210..410484 (+) 1275 WP_000831271.1 hydroxymethylglutaryl-CoA reductase, degradative -
  EL140_RS02050 (NCTC11427_00404) - 410635..411600 (-) 966 WP_000225985.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 633 a.a.        Molecular weight: 68814.11 Da        Isoelectric Point: 8.9717

>NTDB_id=1121836 EL140_RS02025 WP_000614521.1 404716..406617(+) (stkP) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATFQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVVIKATAKKLSDRYQSVSEMYVDLSTSLSYNRRNEPKLVFDDASKADTKALPKVPQSTLTSIPKAPAQEERPQPK
KATQPVAEPAPAPKPAKKRKFKARYMILLASLLLVAASLVWILSRTPATIPIPDVAGQTVAEAKEALKKSKFEAGEEKSE
ASDTVAEGRVIRTDPEAGSGRKEGTKVNLIVSSGKQSFQLSNYVGRKYTDVVAELKEKKVPENLIKMEEEESNESEPGIV
IRQTPASGSTYDLSKATTITLTVAKKVTSVSMPSYIGSSLEFTKNNLTQIVGVKEANIEVVEVSTAPEGTAEGTVVSQTP
RAGELVDLASTRIKLSIYKPKTPPSTSSSNPAQRGNQGSPTSPNQGNQQGNQQGHTPSSSSSNNEGSHESSRD

Nucleotide


Download         Length: 1902 bp        

>NTDB_id=1121836 EL140_RS02025 WP_000614521.1 404716..406617(+) (stkP) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
ATGATCCAAATCGGCAAGATTTTTGCCGGGCGGTATCGGATTGTCAAGCAGATTGGTCGAGGAGGCATGGCAGATGTATA
CTTGGCCAAGGATTTGATCCTAGACGGGGAAGAAGTGGCAGTGAAAGTCCTGAGGACCAACTACCAGACGGACCCGATTG
CTGTGGCACGTTTCCAGCGGGAAGCGAGGGCCATGGCGGATCTGGACCATCCTCATATCGTTCGGATAACAGATATTGGT
GAGGAAGACGGTCAACAGTACCTAGCTATGGAATACGTAGCAGGCCTTGACCTCAAGCGTTATATTAAAGAACACTATCC
TCTTTCAAATGAAGAAGCGGTTCGGATCATGGGGCAAATTCTCTTGGCGATGCGCTTAGCCCATACTCGAGGAATCGTTC
ACCGGGATTTGAAACCTCAAAATATCCTCTTGACACCTGACGGCACAGCTAAGGTCACGGACTTTGGGATTGCCGTAGCC
TTTGCGGAGACCAGTCTGACTCAGACAAACTCGATGCTGGGTTCTGTTCATTATTTGTCACCTGAGCAAGCGCGTGGTTC
TAAAGCGACCTTCCAGAGTGATATCTATGCAATGGGGATTATCTTCTATGAGATGCTGACTGGTCATATTCCTTACGATG
GGGATAGTGCAGTTACGATTGCTCTCCAGCATTTCCAGAAGCCACTTCCGTCCGTCATAGCTGAAAACCCATCTGTCCCT
CAGGCTTTAGAAAATGTTGTCATCAAGGCGACTGCTAAGAAGCTGTCAGACCGTTATCAGTCTGTTTCAGAAATGTATGT
GGACTTGTCAACTAGCTTGTCTTATAATCGTCGGAATGAACCGAAACTGGTCTTTGACGATGCGAGTAAGGCAGACACTA
AGGCTTTACCAAAAGTTCCACAAAGTACACTGACATCGATTCCTAAAGCTCCGGCGCAGGAAGAACGCCCTCAGCCAAAG
AAAGCAACCCAACCAGTCGCTGAGCCAGCACCTGCGCCAAAGCCAGCTAAAAAACGGAAGTTTAAGGCTCGCTATATGAT
TCTTTTAGCTAGTCTTCTATTGGTTGCGGCCTCTTTGGTCTGGATTTTGTCTAGAACACCTGCAACGATTCCCATTCCTG
ATGTGGCTGGACAAACCGTTGCAGAGGCTAAGGAAGCTCTTAAAAAATCCAAATTTGAAGCTGGTGAAGAAAAGTCAGAG
GCCAGCGATACAGTAGCAGAGGGACGTGTTATTCGAACGGATCCAGAAGCTGGTAGCGGCCGAAAAGAAGGAACCAAGGT
TAATTTGATCGTTTCTTCTGGTAAGCAATCCTTCCAATTGAGCAATTATGTTGGACGCAAGTATACGGATGTCGTAGCCG
AACTCAAGGAGAAGAAGGTTCCTGAAAATCTAATCAAGATGGAAGAGGAAGAATCCAATGAAAGCGAACCTGGAATCGTC
ATCAGACAGACCCCTGCTTCGGGTTCGACTTATGATCTCTCAAAAGCCACTACGATTACCTTAACAGTGGCTAAGAAGGT
GACTAGTGTCAGCATGCCTAGCTACATTGGTTCAAGTCTCGAATTTACTAAGAATAATCTGACTCAGATTGTTGGAGTAA
AAGAGGCTAATATCGAAGTTGTTGAAGTATCGACTGCCCCTGAAGGAACGGCAGAAGGAACTGTTGTAAGTCAAACGCCA
AGAGCAGGAGAACTGGTTGATCTTGCAAGTACGCGTATCAAACTTTCCATCTACAAACCAAAAACACCACCGTCAACTTC
ATCCTCTAATCCTGCCCAACGTGGGAACCAGGGTTCTCCTACAAGTCCAAACCAGGGGAACCAACAAGGAAATCAACAAG
GGCACACTCCTTCTAGCAGTTCATCCAATAATGAAGGATCTCACGAAAGTTCTCGAGATTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(441-505)

PASTA domain (PASTA)

(372-432)

PASTA domain (PASTA)

(510-579)

Protein kinase domain (Pkinase)

(12-227)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H9FK75

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

77.986

92.575

0.722
  stkP Streptococcus pneumoniae D39

77.645

92.575

0.719
  stkP Streptococcus pneumoniae R6

77.645

92.575

0.719
  stkP Streptococcus pneumoniae Rx1

77.474

92.575

0.717
  pknB Streptococcus mutans UA159

56.326

91.153

0.513
  stkP/pknB Streptococcus salivarius strain HSISS4

54.124

91.943

0.498

Multiple sequence alignment