Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   EL133_RS02305 Genome accession   NZ_LR134323
Coordinates   455282..457183 (+) Length   633 a.a.
NCBI ID   WP_006739098.1    Uniprot ID   -
Organism   Streptococcus urinalis strain NCTC13766     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 450282..462183
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL133_RS02285 - 451885..452085 (+) 201 WP_006739148.1 hypothetical protein -
  EL133_RS02290 (NCTC13766_00460) fmt 452261..453196 (+) 936 WP_006739491.1 methionyl-tRNA formyltransferase -
  EL133_RS02295 (NCTC13766_00461) rsmB 453186..454508 (+) 1323 WP_006738933.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  EL133_RS02300 (NCTC13766_00462) - 454545..455282 (+) 738 WP_006739689.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  EL133_RS02305 (NCTC13766_00463) pknB 455282..457183 (+) 1902 WP_006739098.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EL133_RS02310 (NCTC13766_00464) liaF 457273..457968 (+) 696 WP_006738642.1 cell wall-active antibiotics response protein LiaF -
  EL133_RS02315 (NCTC13766_00465) - 457965..458990 (+) 1026 WP_006740072.1 sensor histidine kinase -
  EL133_RS02320 (NCTC13766_00466) - 458962..459603 (+) 642 WP_006739571.1 response regulator transcription factor -
  EL133_RS02325 (NCTC13766_00467) - 459640..461040 (+) 1401 WP_006739756.1 Cof-type HAD-IIB family hydrolase -
  EL133_RS02330 (NCTC13766_00468) - 461040..461402 (+) 363 WP_006739454.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 633 a.a.        Molecular weight: 68806.67 Da        Isoelectric Point: 8.1484

>NTDB_id=1121519 EL133_RS02305 WP_006739098.1 455282..457183(+) (pknB) [Streptococcus urinalis strain NCTC13766]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNTEVVRIMEEVLSAMNLAHQKGIVHRDLKPQNILLTKNGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSILEENSNVP
QALENVVIKATAKKLADRYSSTFEMSRDLMTALSYNRSREKKLVFQDSENTKPLPKVVPVPSQNNPDQLLKKQKGAQEEQ
AIKEDTLATPVNKPKKRKKRFIGTFFKVLFALFTVGVALFAFLVLTKPSIATVPNVQGLSLNSAKSKITSAGLKVGSIKE
VESSKISEGYVVKTNPSIGSKTHEGNKINLYVSVGNSSFEMPDYTGKDYNQAVSDLVDQYGVKKSKIKIKKVATTDYDEG
TVISQSPSKGDKFNPNGSSKITLTVAISDTATMPALTDMTYSDAVDTLTSLGISSSRIKVYTPSSSSQKGYVEVSSPSPS
AVISSQTPYYGTAISTTENTEISLYLYSDNTSASQSSSSQETSSTSSSSQSSTSTSSSTTSETSESTSSNEQP

Nucleotide


Download         Length: 1902 bp        

>NTDB_id=1121519 EL133_RS02305 WP_006739098.1 455282..457183(+) (pknB) [Streptococcus urinalis strain NCTC13766]
ATGATACAGATTGGCAAATTATTTGCTGGTCGTTATCGTATTCTAAAATCTATCGGACGTGGTGGTATGGCGGATGTATA
TCTGGCCAATGACTTGATATTAGATAATGAAGAAGTTGCGATTAAAGTGCTTCGAACCAATTATCAAACAGATCAAGTTG
CAGTTGCTCGCTTCCAGCGTGAAGCTAGAGCCATGGCAGAATTGAATCATCCTAATATTGTTGCAATCCGTGACATTGGT
GAAGAAGACGGTCAGCAATTTCTAGTAATGGAATATGTTGATGGTGCTGATTTGAAAAAATATATTCAAGATCATGCACC
ACTATCTAATACGGAAGTTGTTAGAATCATGGAAGAAGTTCTCTCGGCCATGAATCTAGCACATCAAAAGGGAATAGTTC
ATCGAGATTTAAAACCTCAAAATATTTTACTTACGAAAAATGGAACAGTAAAAGTAACAGACTTTGGGATTGCAGTTGCA
TTTGCTGAAACAAGTCTAACACAAACTAATTCTATGTTAGGTAGTGTACACTATCTATCGCCAGAGCAAGCTAGAGGATC
TAAAGCAACAGTTCAAAGTGACATATATGCAATGGGTATAATGCTCTTTGAAATGTTGACAGGTCATATACCTTACGATG
GGGACAGTGCTGTAACTATAGCTTTACAACATTTTCAGAAACCACTCCCATCAATTCTAGAAGAAAATAGTAATGTCCCA
CAAGCTCTTGAAAATGTCGTTATTAAAGCTACAGCAAAGAAGTTGGCAGATCGTTATTCATCGACTTTTGAAATGAGTCG
AGATTTAATGACAGCATTAAGTTATAATCGTAGTCGTGAGAAAAAACTTGTTTTTCAAGATTCTGAGAATACTAAACCAC
TTCCAAAAGTTGTTCCTGTACCAAGTCAGAACAATCCTGATCAATTATTGAAAAAGCAAAAGGGTGCTCAAGAAGAACAA
GCTATAAAAGAAGACACGCTAGCTACACCAGTTAATAAACCTAAGAAGCGTAAGAAAAGATTCATAGGAACTTTCTTTAA
AGTATTATTTGCCTTATTTACGGTTGGTGTTGCCTTATTTGCCTTTTTAGTATTAACAAAACCTTCAATTGCGACAGTAC
CAAATGTACAAGGCCTTAGTTTAAATTCTGCCAAGTCAAAAATTACTTCTGCAGGATTAAAAGTTGGTAGCATTAAAGAA
GTTGAAAGTAGCAAAATTTCTGAAGGTTATGTGGTCAAAACTAATCCAAGTATTGGTTCTAAAACTCATGAAGGCAATAA
AATCAACCTTTATGTTTCAGTAGGGAATTCTAGTTTTGAAATGCCTGATTATACTGGAAAAGATTACAATCAGGCAGTAT
CTGATTTAGTTGATCAATATGGTGTGAAGAAATCAAAAATTAAAATTAAAAAAGTGGCTACAACTGATTATGATGAAGGA
ACTGTGATAAGTCAATCACCATCCAAAGGAGACAAATTTAATCCTAATGGTAGTTCAAAAATCACCTTAACAGTAGCTAT
CAGTGATACCGCAACGATGCCTGCATTGACTGATATGACCTATTCTGATGCTGTTGACACATTAACAAGTCTAGGAATTT
CATCTTCTAGAATTAAAGTGTACACTCCAAGTTCAAGTTCTCAAAAGGGTTATGTTGAAGTAAGTTCACCTTCACCTTCA
GCTGTTATTAGTAGTCAAACACCTTATTATGGTACAGCTATCAGTACAACTGAAAATACGGAAATTAGTTTATATTTATA
TTCTGATAATACTTCAGCAAGTCAATCATCAAGTAGTCAAGAAACGAGTTCAACAAGTAGTAGTTCACAATCGTCAACTA
GCACATCTAGTTCAACAACAAGTGAAACTTCAGAATCTACTAGTTCAAATGAACAACCTTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(512-587)

PASTA domain (PASTA)

(372-433)

Protein kinase domain (Pkinase)

(12-258)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.87

92.575

0.61
  stkP/pknB Streptococcus salivarius strain HSISS4

63.823

92.575

0.591
  stkP Streptococcus pneumoniae TIGR4

58.721

81.517

0.479
  stkP Streptococcus pneumoniae D39

58.607

81.675

0.479
  stkP Streptococcus pneumoniae R6

58.607

81.675

0.479
  stkP Streptococcus pneumoniae Rx1

58.414

81.675

0.477

Multiple sequence alignment