Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EL130_RS03035 Genome accession   NZ_LR134320
Coordinates   576192..576914 (+) Length   240 a.a.
NCBI ID   WP_002273406.1    Uniprot ID   -
Organism   Streptococcus mutans strain NCTC10832     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 571192..581914
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL130_RS03020 (NCTC10832_00570) - 571593..573146 (-) 1554 WP_002266996.1 ABC transporter substrate-binding protein/permease -
  EL130_RS03025 (NCTC10832_00571) - 573298..575199 (+) 1902 WP_002283537.1 DUF2207 domain-containing protein -
  EL130_RS03030 (NCTC10832_00572) - 575257..576102 (+) 846 WP_002275187.1 undecaprenyl-diphosphate phosphatase -
  EL130_RS03035 (NCTC10832_00573) mecA 576192..576914 (+) 723 WP_002273406.1 adaptor protein MecA Regulator
  EL130_RS03040 (NCTC10832_00574) rgpG 576920..578080 (+) 1161 WP_002283536.1 rhamnose-glucose polysaccharide biosynthesis protein RgpB -
  EL130_RS03045 (NCTC10832_00575) sufC 578154..578924 (+) 771 WP_002262747.1 Fe-S cluster assembly ATPase SufC -
  EL130_RS03050 (NCTC10832_00576) sufD 578962..580224 (+) 1263 WP_002283535.1 Fe-S cluster assembly protein SufD -
  EL130_RS03055 (NCTC10832_00577) - 580229..581458 (+) 1230 WP_002283534.1 cysteine desulfurase -
  EL130_RS03060 (NCTC10832_00578) sufU 581445..581879 (+) 435 WP_002262744.1 Fe-S cluster assembly sulfur transfer protein SufU -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 28029.61 Da        Isoelectric Point: 4.2116

>NTDB_id=1121412 EL130_RS03035 WP_002273406.1 576192..576914(+) (mecA) [Streptococcus mutans strain NCTC10832]
MEMKQISETTLKITISMEDLEERGMELKDFLIPQEKTEEFFYTVMDELDLPENFKDSGMLSFRVTPRNDRIDVFVTKSEI
NKNLNLEDLSDFDDISKMSPEDFFNTLEETMREKGDAAALDKLAEIEKREEEKTQQEKGETKEKRDYVHFVLDFPDIQQV
ISFAKTVDYDVEASELFKESDAYHMTVLLNLEDKPDYYADLMFARMLEHAGRGTKTRAYLLEHGVQLIKADALQELQMIG

Nucleotide


Download         Length: 723 bp        

>NTDB_id=1121412 EL130_RS03035 WP_002273406.1 576192..576914(+) (mecA) [Streptococcus mutans strain NCTC10832]
ATGGAAATGAAACAAATCAGCGAAACAACATTAAAAATCACCATCAGTATGGAAGATTTAGAAGAAAGAGGCATGGAATT
AAAAGATTTCTTGATTCCGCAGGAAAAGACGGAAGAATTTTTCTATACTGTTATGGATGAGCTGGACTTGCCTGAAAATT
TCAAGGACAGTGGGATGTTAAGCTTTCGAGTAACACCAAGGAATGATCGCATTGATGTTTTTGTCACTAAGTCAGAAATC
AATAAAAATCTTAATTTGGAGGATTTGTCTGATTTTGATGATATTTCAAAAATGTCCCCGGAGGATTTCTTTAATACCTT
GGAGGAAACCATGCGTGAAAAAGGGGATGCTGCAGCTCTGGATAAATTGGCTGAAATTGAAAAAAGAGAAGAAGAGAAGA
CTCAGCAGGAAAAAGGTGAAACTAAGGAAAAAAGAGATTACGTTCACTTTGTGCTGGATTTTCCTGATATTCAGCAAGTC
ATAAGTTTTGCTAAGACAGTTGACTATGATGTAGAGGCTTCAGAACTTTTTAAGGAGTCTGACGCTTATCACATGACTGT
TCTGCTTAATCTCGAAGATAAACCTGACTATTATGCTGATCTTATGTTTGCAAGAATGTTGGAGCATGCTGGTAGAGGAA
CAAAGACACGTGCTTATCTATTAGAACATGGAGTTCAGCTCATTAAAGCAGATGCTCTGCAAGAATTACAAATGATTGGA
TAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-236)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

99.167

100

0.992
  mecA Streptococcus thermophilus LMD-9

58.197

100

0.592
  mecA Streptococcus thermophilus LMG 18311

57.787

100

0.588
  mecA Streptococcus pneumoniae Rx1

48.571

100

0.496
  mecA Streptococcus pneumoniae D39

48.571

100

0.496
  mecA Streptococcus pneumoniae R6

48.571

100

0.496
  mecA Streptococcus pneumoniae TIGR4

48.571

100

0.496

Multiple sequence alignment