Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   EL136_RS00815 Genome accession   NZ_LR134317
Coordinates   160773..162668 (+) Length   631 a.a.
NCBI ID   WP_012677494.1    Uniprot ID   -
Organism   Streptococcus equi subsp. zooepidemicus strain NCTC6180     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 155773..167668
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL136_RS00800 (NCTC6180_00164) fmt 157751..158686 (+) 936 WP_041785676.1 methionyl-tRNA formyltransferase -
  EL136_RS00805 (NCTC6180_00165) rsmB 158676..159998 (+) 1323 WP_154803605.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  EL136_RS00810 (NCTC6180_00166) - 160036..160776 (+) 741 WP_012516146.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  EL136_RS00815 (NCTC6180_00167) pknB 160773..162668 (+) 1896 WP_012677494.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EL136_RS00820 (NCTC6180_00168) liaF 162801..163493 (+) 693 WP_021321067.1 cell wall-active antibiotics response protein LiaF -
  EL136_RS00825 (NCTC6180_00169) - 163490..164494 (+) 1005 WP_012516143.1 sensor histidine kinase -
  EL136_RS00830 (NCTC6180_00170) - 164487..165128 (+) 642 WP_021321066.1 response regulator -
  EL136_RS00835 (NCTC6180_00171) - 165162..166562 (+) 1401 WP_154803606.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  EL136_RS00840 (NCTC6180_00172) - 166562..166924 (+) 363 WP_012516140.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68568.74 Da        Isoelectric Point: 6.6073

>NTDB_id=1121255 EL136_RS00815 WP_012677494.1 160773..162668(+) (pknB) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKSGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENPNVP
QALENVVIRATAKKLSDRYRSTFEMSRDLMTALSYNRSRERKVVFDDVESTKPLPKVTPTPVTAPKVSNASQASAAADAR
LEQTSQMDTLQKPQKKKKNGRFLGTLLKILFSFFVVGVALFAYLVLTKPTTVKVPDVTGSSLNAAKQVLEEAGLKVGKVH
QIESDTVSEDQVVKTNPQAGSAKRKGSSVDLYLSIGNKGFEMENYKGQDYQDVMTSLTETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGEKFNPAGKSKITLSVAVGDTVIMPMVTEYSYADAVNTLTALGIDAARIKAYVPSSSSPTGFVQVSSPSS
KAIVSGQTPYYGTQISLSEKGDISLYLYPEETRASSSSSSSDTSAPNPSAGDTTDSSSHTELGQNDAVTTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=1121255 EL136_RS00815 WP_012677494.1 160773..162668(+) (pknB) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
ATGATTCAGATTGGCAAGCTATTTGCTGGTCGTTATCGCATTCTAAAATCTATAGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAACGATTTGATTCTGGATAATGAGGACGTTGCCATTAAGGTCTTGCGGACCAATTATCAAACAGATCAGGTTG
CTGTTGCGCGTTTTCAAAGAGAAGCGCGAGCCATGGCTGAATTAAATCACCCCAATATTGTTGCCATTCGGGATATAGGC
GAGGAAGACGGACAGCAATTTTTAGTAATGGAATACGTTGATGGCTCTGACTTGAAAAAATACATTCAGGATCATGCGCC
ATTATCCAACAATGAGGTGGTGAGAATCATGGAGGAGGTTCTTTCTGCCATGACTCTGGCCCATCAAAAAGGAATTGTCC
ACAGGGATTTAAAGCCTCAAAACATTCTTTTAACCAAATCAGGTGTTGTTAAGGTTACAGATTTTGGGATTGCTGTTGCC
TTTGCAGAGACCAGCCTAACCCAGACAAATTCTATGCTAGGAAGTGTGCATTACCTCTCACCTGAGCAAGCGCGTGGTTC
TAAAGCGACGATTCAAAGTGATATTTACGCGATGGGAATCATGCTCTTTGAAATGCTAACAGGGCATATTCCTTATGATG
GCGATAGCGCTGTGACGATTGCTCTGCAGCATTTTCAAAAGCCGCTGCCCTCTATCATTGATGAAAATCCTAATGTGCCT
CAAGCCTTGGAAAACGTTGTTATTCGGGCCACTGCCAAAAAGCTAAGTGACCGTTATCGCTCGACCTTTGAGATGAGCAG
GGATTTGATGACAGCCCTTAGCTATAACCGCAGTCGTGAGCGTAAGGTTGTCTTTGATGATGTCGAAAGCACAAAGCCCT
TGCCAAAGGTAACACCGACTCCTGTAACAGCACCTAAGGTATCAAATGCTAGTCAGGCATCTGCGGCAGCTGATGCTAGA
CTTGAGCAGACTAGCCAGATGGATACTCTGCAAAAGCCTCAAAAAAAGAAAAAAAATGGGCGTTTTCTAGGAACACTCTT
AAAAATCTTGTTTTCCTTTTTTGTTGTTGGTGTGGCTCTTTTTGCTTATTTGGTCTTGACCAAGCCAACTACGGTTAAGG
TTCCTGATGTGACAGGCTCTAGTCTCAATGCTGCCAAGCAGGTCTTGGAGGAGGCGGGACTAAAGGTCGGTAAGGTCCAT
CAGATTGAAAGTGACACAGTTAGTGAGGATCAGGTGGTTAAGACAAATCCTCAAGCTGGCTCAGCTAAGCGAAAAGGCTC
CAGCGTTGACCTTTACCTTTCGATCGGAAATAAAGGCTTTGAGATGGAAAATTATAAGGGACAGGATTATCAAGATGTGA
TGACCAGTCTGACTGAGACCTATGGCGTACCAAAGTCAAAAATCAAGATTGAGCGTATCGTGACAAATGAATACCCTGAA
AACACCGTTATTAGCCAGTCTCCAAGCGCAGGAGAAAAATTTAACCCAGCTGGTAAATCCAAGATTACGCTTAGTGTAGC
AGTGGGCGATACGGTCATCATGCCAATGGTAACTGAGTACAGCTATGCAGATGCGGTGAATACACTAACAGCCCTAGGAA
TTGATGCCGCAAGAATCAAGGCCTATGTACCAAGCTCCAGCTCTCCGACAGGCTTTGTGCAGGTGAGCTCCCCAAGCTCA
AAGGCGATTGTCAGTGGGCAGACACCGTATTATGGTACCCAGATTAGCCTTTCTGAAAAGGGTGATATTAGCCTCTACCT
CTACCCTGAGGAGACACGTGCATCAAGCAGCTCATCGAGCTCTGATACCTCGGCTCCTAATCCATCAGCTGGAGATACAA
CAGACTCAAGCAGTCATACCGAATTAGGTCAAAATGACGCTGTTACAACACCGTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(372-434)

PASTA domain (PASTA)

(512-588)

PASTA domain (PASTA)

(441-506)

Protein kinase domain (Pkinase)

(12-232)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.714

94.295

0.62
  stkP/pknB Streptococcus salivarius strain HSISS4

62.415

93.185

0.582
  stkP Streptococcus pneumoniae TIGR4

57.558

81.775

0.471
  stkP Streptococcus pneumoniae D39

57.171

81.775

0.468
  stkP Streptococcus pneumoniae R6

57.171

81.775

0.468
  stkP Streptococcus pneumoniae Rx1

56.977

81.775

0.466

Multiple sequence alignment