Detailed information NTG1121237

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: EL139_RS08650
• Genome accession: NZ_LR134316
• Coordinates: 1734364..1735038 (+)
• Length: 224 a.a.
• NCBI ID: WP_111716510.1
• Uniprot ID: A0A9X8SZN6
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1729364..1740038

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL139_RS08635 (NCTC6181_01767)	pstB	1729934..1730692 (+)	759	WP_003057749.1	phosphate ABC transporter ATP-binding protein PstB	-
EL139_RS08640 (NCTC6181_01768)	phoU	1730770..1731423 (+)	654	WP_111716515.1	phosphate signaling complex protein PhoU	-
EL139_RS08645 (NCTC6181_01769)	-	1731623..1734160 (+)	2538	WP_111716513.1	M1 family metallopeptidase	-
EL139_RS08650 (NCTC6181_01770)	ciaR	1734364..1735038 (+)	675	WP_111716510.1	response regulator transcription factor	Regulator
EL139_RS08655 (NCTC6181_01771)	ciaH	1735031..1736341 (+)	1311	WP_111716507.1	HAMP domain-containing sensor histidine kinase	Regulator
EL139_RS08660 (NCTC6181_01772)	rpsT	1736499..1736747 (-)	249	WP_009881183.1	30S ribosomal protein S20	-
EL139_RS08665 (NCTC6181_01773)	coaA	1736801..1737721 (-)	921	WP_111716505.1	type I pantothenate kinase	-
EL139_RS08670 (NCTC6181_01774)	-	1737990..1738589 (+)	600	WP_015057597.1	class I SAM-dependent methyltransferase	-
EL139_RS08675 (NCTC6181_01775)	-	1738576..1739853 (+)	1278	WP_111716503.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25563.48 Da
• Isoelectric Point: 4.4123

>NTDB_id=1121237 EL139_RS08650 WP_111716510.1 1734364..1735038(+) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGQKEVQVDGQSIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVDKLQTLRSVGYILKSHE

Nucleotide

• Length: 675 bp

>NTDB_id=1121237 EL139_RS08650 WP_111716510.1 1734364..1735038(+) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181]
ATGATCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATTATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACATGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACGGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAATGTCGTAG
TGGATTTAGGACAAAAAGAAGTTCAAGTGGATGGCCAGTCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTTTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATTTTGTGGACAAACTGCAGACATTGA
GAAGCGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	84.163	98.661	0.83
ciaR	Streptococcus pneumoniae D39	84.163	98.661	0.83
ciaR	Streptococcus pneumoniae R6	84.163	98.661	0.83
ciaR	Streptococcus pneumoniae TIGR4	84.163	98.661	0.83
ciaR	Streptococcus mutans UA159	84.163	98.661	0.83
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.326	100	0.388
vicR	Streptococcus mutans UA159	35.443	100	0.375