Detailed information NTG1121229

Bioinformatically predicted

Overview

• Name: pknB
• Type: Regulator
• Locus tag: EL139_RS06240
• Genome accession: NZ_LR134316
• Coordinates: 1217979..1219874 (+)
• Length: 631 a.a.
• NCBI ID: WP_111717291.1
• Uniprot ID: A0A9X8XG98
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181
• Function: modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology) Competence regulation

Genomic Context

Location: 1212979..1224874

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL139_RS06225 (NCTC6181_01267)	fmt	1214957..1215892 (+)	936	WP_111717295.1	methionyl-tRNA formyltransferase	-
EL139_RS06230 (NCTC6181_01268)	rsmB	1215882..1217204 (+)	1323	WP_111717943.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
EL139_RS06235 (NCTC6181_01269)	-	1217242..1217982 (+)	741	WP_111717293.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
EL139_RS06240 (NCTC6181_01270)	pknB	1217979..1219874 (+)	1896	WP_111717291.1	Stk1 family PASTA domain-containing Ser/Thr kinase	Regulator
EL139_RS06245 (NCTC6181_01271)	liaF	1220001..1220693 (+)	693	WP_111717289.1	cell wall-active antibiotics response protein LiaF	-
EL139_RS06250 (NCTC6181_01272)	-	1220690..1221694 (+)	1005	WP_003061197.1	sensor histidine kinase	-
EL139_RS06255 (NCTC6181_01273)	-	1221687..1222328 (+)	642	WP_014612503.1	response regulator transcription factor	-
EL139_RS06260 (NCTC6181_01274)	-	1222365..1223765 (+)	1401	WP_111717286.1	bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase	-
EL139_RS06265 (NCTC6181_01275)	-	1223765..1224124 (+)	360	WP_111717284.1	S1 RNA-binding domain-containing protein	-

Sequence

Protein

• Length: 631 a.a.
• Molecular weight: 68859.29 Da
• Isoelectric Point: 7.2901

>NTDB_id=1121229 EL139_RS06240 WP_111717291.1 1217979..1219874(+) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPVTTPKVAPTPVTSTTESRL
EHTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPNVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPPTGTAKRKGSAITVYLSIGNKGFEMENYKGIDYQEAMASLMETYGVPKSKIKIERIVTNEYTEN
TVISQSPSSGDKFNPNGKYKITLSVAVSDTVIMPMVTEYTYADAVNTLTALGIEASRIKAYAPSSSSATGFVQVNSPSSK
AIVSGQTPYYGTTLSLSEKGEISLYLYPEETHSSSSSTSSEASSSISSTNDGTGTSSNTELSPSESTGQTP

Nucleotide

• Length: 1896 bp

>NTDB_id=1121229 EL139_RS06240 WP_111717291.1 1217979..1219874(+) (pknB) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTACGTACCAATTATCAGACAGATCAGGTAG
CGGTTGCCCGTTTCCAACGGGAAGCGCGTGCCATGGCTGAGTTAAACCATCCTAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATACGTAGATGGCGCTGACTTAAAGAAGTATATTCAAGATCATGCTCC
TCTATCCAATAATGAAGTGGTCAGAATCATGGAAGAGGTGCTTTCTGCCATGACATTAGCTCACCAGAAAGGGATTGTTC
ATAGAGATTTAAAACCTCAAAACATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGACTTTGGGATTGCCGTTGCT
TTTGCGGAAACGAGTTTGACTCAAACCAACTCTATGTTGGGAAGCGTCCATTACCTATCGCCTGAGCAGGCTCGCGGCTC
AAAAGCGACCATTCAAAGTGATATTTATGCGATGGGAATTATGCTCTTTGAAATGTTGACAGGACATATCCCTTATGATG
GCGATAGTGCTGTTACCATTGCTTTGCAACATTTCCAAAAGCCTCTTCCGTCTATTATTGACGAAAACCACAATGTACCG
CAAGCTTTAGAGAATGTGGTTATCCGAGCAACAGCTAAGAAATTAAGCGATCGTTACGGATCAACCTTTGAAATGAGTCG
TGATCTGATGACGGCTCTCAGTTACAACCGGAGTCGTGAACGGAAAGTTATTTTTGATGATGTGGAAAGCACAAAACCTC
TCCCTAAAGTAACACCGGCACCAGTAACGACGCCAAAAGTAGCTCCAACTCCTGTTACGTCCACAACTGAAAGTCGTTTA
GAACACACTAATCAGATGGATACACTCCAGAAACCACAAAAAAAGAAGCGAAATGGTCGTTTCTTGGGTACTTTGTTAAA
AATCCTCTTTTCTCTCTTTATTGTAGGTGTGGCTCTCTTCACTTACTTGGTGCTAACAAAACCTACCTCAGTAAAAGTTC
CTAATGTGACAGGTGTCAGTCTTAAAGTTGCAAAGCAGGAACTGCAAGATTTAGGCTTGAAAGTTGGTAAGGTGAGACAG
ATTGAAAGTGATACTGTTGCGGAAGGGAATGTTGTCCGAACAGATCCACCAACGGGAACAGCCAAGCGCAAGGGTTCAGC
TATCACAGTTTACTTGTCAATTGGCAATAAAGGGTTTGAGATGGAAAACTACAAAGGGATTGATTATCAAGAAGCCATGG
CTAGCTTGATGGAAACCTACGGTGTTCCTAAATCGAAGATTAAGATTGAACGAATCGTGACCAATGAATACACGGAAAAT
ACTGTTATTAGCCAATCTCCGAGTTCAGGGGATAAATTTAATCCTAATGGGAAATATAAAATTACTCTTAGTGTTGCCGT
GAGTGACACAGTCATTATGCCTATGGTAACAGAATATACCTATGCTGATGCAGTAAATACTTTGACAGCATTAGGTATTG
AAGCTTCGAGGATTAAAGCTTATGCTCCAAGCTCAAGTTCAGCAACAGGTTTTGTTCAGGTTAATTCTCCAAGTTCAAAA
GCTATTGTCAGTGGTCAAACCCCTTATTACGGTACCACTTTGAGCCTCTCTGAAAAAGGTGAGATAAGCCTTTACCTTTA
CCCAGAAGAAACGCATTCTTCAAGTAGTTCAACCAGTTCTGAGGCAAGTTCTAGCATTTCCTCAACAAATGATGGAACGG
GAACAAGTAGTAATACTGAATTAAGCCCATCGGAATCAACTGGTCAAACCCCTTAA

Domains

Predicted by InterproScan.

• Protein kinase domain (Pkinase) (12-233)

• PASTA domain (PASTA) (440-505)

• PASTA domain (PASTA) (511-587)

• PASTA domain (PASTA) (371-433)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pknB	Streptococcus mutans UA159	65.358	92.868	0.607
stkP/pknB	Streptococcus salivarius strain HSISS4	62.017	94.295	0.585
stkP	Streptococcus pneumoniae TIGR4	58.221	81.933	0.477
stkP	Streptococcus pneumoniae D39	58.027	81.933	0.475
stkP	Streptococcus pneumoniae R6	58.027	81.933	0.475
stkP	Streptococcus pneumoniae Rx1	57.834	81.933	0.474