Detailed information NTG1121215

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EL139_RS03360
• Genome accession: NZ_LR134316
• Coordinates: 614934..616154 (-)
• Length: 406 a.a.
• NCBI ID: WP_111717869.1
• Uniprot ID: A0A9X8XGP3
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181
• Function: require for competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	616844..618364	614934..616154	flank	690

Gene organization within MGE regions

Location: 614934..618364

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL139_RS03360 (NCTC6181_00685)	htrA	614934..616154 (-)	1221	WP_111717869.1	trypsin-like peptidase domain-containing protein	Regulator
EL139_RS03365 (NCTC6181_00686)	rlmH	616364..616843 (+)	480	WP_111717867.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL139_RS03370 (NCTC6181_00687)	-	616923..618364 (-)	1442	Protein_622	IS1182 family transposase	-

Sequence

Protein

• Length: 406 a.a.
• Molecular weight: 42487.85 Da
• Isoelectric Point: 5.2146

>NTDB_id=1121215 EL139_RS03360 WP_111717869.1 614934..616154(-) (htrA) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181]
MPSMKHILKSLGILLIGFFGGLLAIFTFNATQQSSSTSHTGSATTSKMVFNNTTDTTKAVKVVQNAVVSVINYQVDPSSS
LSNPYTKLFGENQTRENKDADLAIFSEGSGVIYRKDGDSAYVVTNNHVIDGAKRIEILMADGTKVVGELVGADTYSDLAV
VKIASDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTEGIVSSLSRTVTLKNEDGETVSTNAIQTDAAINPGNSG
GPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSSDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQI
NIPTGVTGGIVVASVQDGMPASGKLGQYDVITEIDGKAVNSISDLQSNLYGHDINDTIKVTFYRGTTKKKADITLTKTTQ
DLTKKQ

Nucleotide

• Length: 1221 bp

>NTDB_id=1121215 EL139_RS03360 WP_111717869.1 614934..616154(-) (htrA) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181]
ATGCCATCTATGAAACATATCTTAAAATCCTTAGGCATTTTACTCATTGGATTTTTTGGAGGATTGTTAGCAATTTTCAC
TTTTAATGCTACTCAACAGTCTTCCTCTACCTCACATACTGGTAGTGCGACGACGAGTAAGATGGTTTTTAATAATACTA
CTGACACAACAAAAGCGGTTAAAGTCGTTCAAAATGCAGTAGTATCAGTGATTAACTATCAAGTAGATCCTTCTTCATCT
CTTTCAAATCCCTACACAAAACTCTTTGGAGAAAATCAAACAAGAGAAAATAAAGATGCCGACTTAGCAATTTTTAGTGA
AGGTTCTGGTGTTATTTATCGAAAAGACGGTGATTCTGCATATGTTGTTACTAATAATCACGTCATTGACGGCGCAAAGC
GAATTGAAATTCTTATGGCAGACGGTACCAAAGTCGTAGGGGAGTTAGTTGGAGCTGATACTTACTCTGACTTAGCGGTT
GTTAAAATTGCCTCAGATAAAATTAAGACAGTTGCTGAATTTGCAGATTCTACTAAACTGAATGTCGGAGAAGTTGCTAT
CGCAATTGGTAGCCCATTAGGAACTCAGTATGCCAATTCTGTTACAGAAGGGATTGTTTCTAGTCTCAGTCGTACCGTCA
CCTTAAAAAATGAAGATGGGGAAACTGTTTCAACAAATGCCATTCAAACTGATGCTGCGATCAATCCCGGAAATTCTGGT
GGTCCGCTCATCAATATTGAAGGACAGGTTATTGGTATCAATTCAAGTAAAATTTCTTCTACCCCAACAGGAAGTAACGG
CAATAGTGGAGCGGTTGAAGGTATCGGTTTTGCTATTCCATCCAGTGATGTCATTAAAATCATTAAGCAATTAGAAACCA
ATGGTGAGGTTATCAGACCTGCCCTTGGAATCTCTATGGTTAATCTAAATGATTTATCAACGAATGCTCTCAGTCAAATT
AATATCCCTACTGGGGTGACGGGTGGTATTGTGGTCGCTTCTGTTCAAGATGGAATGCCAGCTAGTGGTAAACTTGGCCA
GTACGACGTTATTACTGAAATTGATGGTAAAGCCGTCAACTCAATCAGTGATCTTCAAAGCAACCTATACGGCCATGACA
TTAACGATACCATCAAGGTAACCTTTTATAGAGGGACAACCAAGAAAAAAGCAGATATTACCTTAACTAAAACAACCCAG
GATTTGACCAAAAAGCAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (300-395)

• Trypsin-like peptidase domain (Trypsin_2) (108-253)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	60.945	99.015	0.603
htrA	Streptococcus mitis NCTC 12261	54.412	100	0.547
htrA	Streptococcus pneumoniae Rx1	54.412	100	0.547
htrA	Streptococcus pneumoniae TIGR4	54.412	100	0.547
htrA	Streptococcus pneumoniae D39	54.412	100	0.547
htrA	Streptococcus pneumoniae R6	54.412	100	0.547
htrA	Streptococcus gordonii str. Challis substr. CH1	54.95	99.507	0.547