Detailed information NTG1121156

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EL107_RS07525
• Genome accession: NZ_LR134314
• Coordinates: 1475131..1476042 (-)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8302
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1470131..1481042

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL107_RS07505 (NCTC8302_01487)	-	1471136..1472911 (-)	1776	WP_011184071.1	acyltransferase family protein	-
EL107_RS07510 (NCTC8302_01488)	-	1472908..1473309 (-)	402	WP_002986671.1	MORN repeat-containing protein	-
EL107_RS07515 (NCTC8302_01489)	-	1473332..1473769 (-)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
EL107_RS07520 (NCTC8302_01490)	ruvB	1473907..1474905 (-)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
EL107_RS09755 (NCTC8302_01491)	comS	1474952..1475047 (-)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
EL107_RS07525 (NCTC8302_01492)	comR	1475131..1476042 (-)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
EL107_RS07530 (NCTC8302_01493)	purB	1476173..1477465 (-)	1293	WP_011184069.1	adenylosuccinate lyase	-
EL107_RS07540 (NCTC8302_01494)	-	1477681..1479021 (-)	1341	WP_011184068.1	hypothetical protein	-
EL107_RS07545 (NCTC8302_01495)	purK	1479042..1480115 (-)	1074	WP_011888523.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EL107_RS07550 (NCTC8302_01496)	purE	1480102..1480593 (-)	492	WP_021340277.1	5-(carboxyamino)imidazole ribonucleotide mutase	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1121156 EL107_RS07525 WP_002986681.1 1475131..1476042(-) (comR) [Streptococcus pyogenes strain NCTC8302]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1121156 EL107_RS07525 WP_002986681.1 1475131..1476042(-) (comR) [Streptococcus pyogenes strain NCTC8302]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462