Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EL115_RS01910 Genome accession   NZ_LR134307
Coordinates   362792..363547 (+) Length   251 a.a.
NCBI ID   WP_003070299.1    Uniprot ID   F9P4C7
Organism   Streptococcus milleri strain NCTC10708     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 357792..368547
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL115_RS01895 (NCTC10708_00382) - 358175..359740 (-) 1566 WP_058670186.1 ABC transporter substrate-binding protein/permease -
  EL115_RS01900 (NCTC10708_00383) - 359868..361757 (+) 1890 WP_126441184.1 DUF2207 domain-containing protein -
  EL115_RS01905 (NCTC10708_00384) - 361824..362666 (+) 843 WP_126441185.1 undecaprenyl-diphosphate phosphatase -
  EL115_RS01910 (NCTC10708_00385) mecA 362792..363547 (+) 756 WP_003070299.1 adaptor protein MecA Regulator
  EL115_RS01915 (NCTC10708_00386) - 363538..364704 (+) 1167 WP_022524656.1 glycosyltransferase family 4 protein -
  EL115_RS01920 (NCTC10708_00387) sufC 364796..365566 (+) 771 WP_003070295.1 Fe-S cluster assembly ATPase SufC -
  EL115_RS01925 (NCTC10708_00388) sufD 365606..366874 (+) 1269 WP_126441186.1 Fe-S cluster assembly protein SufD -
  EL115_RS01930 (NCTC10708_00389) - 366883..368115 (+) 1233 WP_126441187.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 251 a.a.        Molecular weight: 29014.77 Da        Isoelectric Point: 4.1166

>NTDB_id=1120870 EL115_RS01910 WP_003070299.1 362792..363547(+) (mecA) [Streptococcus milleri strain NCTC10708]
MEMKQISDTTIKITIKLEDLEERGMEMADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDRLDVFVTKSKI
DKNLNFDDLADLPDVEELSQMSPDEFLKTLEKNIFEKSKDDIEAVRSLETAEAENNMSTSDIEDQEENSDDLTQKYIYYI
LKFSSLKEAIVFSKTVDYAVNTSELYKMDGYYYLTILVDIEGHPKRYPAWLLASMREHAEDTDVTRAVLQEHGYLLLVNE
AVASLQKVKCS

Nucleotide


Download         Length: 756 bp        

>NTDB_id=1120870 EL115_RS01910 WP_003070299.1 362792..363547(+) (mecA) [Streptococcus milleri strain NCTC10708]
ATGGAAATGAAGCAAATTAGTGATACAACGATTAAGATCACAATAAAATTAGAAGATTTAGAAGAACGTGGAATGGAGAT
GGCAGATTTTCTCGTTCCGCAAGAAAAGACAGAAGAGTTTTTCTATGCAATTTTAGATGAGTTGGAAATGCCAGAGAGTT
TTTTGGATAGCGGTATGCTCAGTTTTCGTGTAACTCCTAAACCAGACCGACTGGATGTTTTTGTCACCAAGTCTAAGATT
GATAAGAATCTGAACTTTGATGATTTGGCAGATTTACCAGATGTAGAAGAGCTGTCTCAAATGTCTCCAGATGAATTTTT
AAAGACATTAGAAAAAAATATTTTTGAGAAAAGCAAAGACGATATTGAAGCTGTTCGGTCTTTGGAAACGGCAGAAGCAG
AAAATAATATGAGCACTTCTGACATAGAAGATCAAGAAGAAAACAGTGACGACCTTACTCAAAAATATATCTATTATATC
TTGAAATTTTCCAGCTTGAAAGAAGCGATTGTCTTTTCTAAAACAGTAGACTATGCTGTTAACACTTCGGAGTTGTACAA
AATGGATGGTTACTATTATTTAACAATCTTGGTTGATATTGAAGGACATCCTAAGCGTTATCCAGCTTGGCTTTTGGCTT
CTATGCGTGAACATGCGGAAGACACAGATGTAACAAGAGCTGTTTTGCAAGAGCATGGTTATTTACTGCTTGTCAACGAG
GCGGTTGCTAGTCTTCAAAAGGTTAAATGCTCATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F9P4C7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

66.532

98.805

0.657
  mecA Streptococcus pneumoniae D39

66.532

98.805

0.657
  mecA Streptococcus pneumoniae R6

66.532

98.805

0.657
  mecA Streptococcus pneumoniae TIGR4

66.129

98.805

0.653
  mecA Streptococcus mutans UA159

50

98.805

0.494
  mecA Streptococcus thermophilus LMD-9

46.304

100

0.474
  mecA Streptococcus thermophilus LMG 18311

45.914

100

0.47

Multiple sequence alignment