Detailed information NTG1120538

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: EL096_RS03440
• Genome accession: NZ_LR134294
• Coordinates: 661534..662238 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain NCTC12977
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 656534..667238

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL096_RS03410 (NCTC12977_00664)	-	656723..657709 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
EL096_RS03415 (NCTC12977_00665)	-	657972..658745 (-)	774	WP_044811410.1	potassium channel family protein	-
EL096_RS03420 (NCTC12977_00666)	-	658792..659046 (-)	255	WP_001812387.1	type II toxin-antitoxin system RelE family toxin	-
EL096_RS03425 (NCTC12977_00667)	relB	659048..659290 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
EL096_RS03430 (NCTC12977_00668)	vicX	659381..660190 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
EL096_RS03435 (NCTC12977_00669)	micB	660192..661541 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
EL096_RS03440 (NCTC12977_00670)	micA	661534..662238 (-)	705	WP_000722076.1	response regulator YycF	Regulator
EL096_RS03445 (NCTC12977_00671)	mutY	662293..663468 (-)	1176	WP_000886125.1	A/G-specific adenine glycosylase	-
EL096_RS03455 (NCTC12977_00672)	-	663797..665467 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
EL096_RS03460 (NCTC12977_00673)	coaB	665697..666386 (+)	690	WP_000699498.1	phosphopantothenate--cysteine ligase	-
EL096_RS03465 (NCTC12977_00674)	coaC	666398..666949 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1120538 EL096_RS03440 WP_000722076.1 661534..662238(-) (micA) [Streptococcus pneumoniae strain NCTC12977]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1120538 EL096_RS03440 WP_000722076.1 661534..662238(-) (micA) [Streptococcus pneumoniae strain NCTC12977]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38