Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   EL097_RS05700 Genome accession   NZ_LR134293
Coordinates   1099926..1101821 (+) Length   631 a.a.
NCBI ID   WP_099982918.1    Uniprot ID   A0A2D4DM60
Organism   Streptococcus canis strain NCTC12191     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1094926..1106821
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL097_RS05685 (NCTC12191_01117) fmt 1096904..1097839 (+) 936 WP_003044727.1 methionyl-tRNA formyltransferase -
  EL097_RS05690 (NCTC12191_01118) rsmB 1097829..1099151 (+) 1323 WP_099982919.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  EL097_RS05695 (NCTC12191_01119) - 1099189..1099929 (+) 741 WP_003044720.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  EL097_RS05700 (NCTC12191_01120) pknB 1099926..1101821 (+) 1896 WP_099982918.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EL097_RS05705 (NCTC12191_01121) liaF 1101948..1102640 (+) 693 WP_003044714.1 cell wall-active antibiotics response protein LiaF -
  EL097_RS05710 (NCTC12191_01122) - 1102637..1103641 (+) 1005 WP_003044712.1 sensor histidine kinase -
  EL097_RS05715 (NCTC12191_01123) - 1103634..1104275 (+) 642 WP_003044709.1 response regulator transcription factor -
  EL097_RS05720 (NCTC12191_01124) - 1104312..1105712 (+) 1401 WP_003044706.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  EL097_RS05725 (NCTC12191_01125) - 1105712..1106071 (+) 360 WP_003044703.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68841.17 Da        Isoelectric Point: 6.9928

>NTDB_id=1120509 EL097_RS05700 WP_099982918.1 1099926..1101821(+) (pknB) [Streptococcus canis strain NCTC12191]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPTPMTTPKVAPTPVTSTTESRL
EQTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPDVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPQAGTAKRKGSSVTVYLSIGNKGFEMENYKGVDYQDAMNSLMETYGIPKSKIKIERIVTNEYPEN
TVISQSPSAGDKFNPNGKSKITLSVAVSDTVIMPMVTEYSYADAVNTLTALGIDASRIKAYAPSSSSATGFIQVNSPSSK
AIVSGQMPYYGTTLSLSEKGEISLYLYPEETHSSSSSSSSESSSSSSSTSDGTGTSSNTELNPSESTGQTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=1120509 EL097_RS05700 WP_099982918.1 1099926..1101821(+) (pknB) [Streptococcus canis strain NCTC12191]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGTATTCTAAAGTCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTGGCAAATGATTTGATCTTGGATAATGAAGACGTTGCAATCAAAGTTTTGCGTACCAATTATCAAACAGATCAGGTGG
CAGTTGCGCGTTTCCAACGGGAAGCGCGGGCCATGGCTGAATTGAATCATCCGAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATATGTTGATGGTGCTGACCTAAAGAAGTACATTCAAGATCATGCACC
GCTATCCAATAACGAAGTGGTTAGAATCATGGAAGAGGTTCTTTCTGCCATGACTCTGGCTCACCAAAAAGGAATTGTGC
ATAGGGATTTAAAACCTCAAAACATTCTCTTAACTAAAAATGGTGTGGTTAAGGTGACTGACTTTGGGATTGCTGTTGCC
TTTGCAGAAACGAGTTTGACTCAGACCAACTCGATGTTAGGTAGTGTGCATTATTTGTCTCCGGAGCAGGCTCGTGGTTC
AAAGGCAACTATCCAAAGTGACATTTATGCAATGGGGATTATGCTCTTTGAAATGCTGACAGGGCATATTCCTTATGACG
GTGACAGTGCTGTTACGATTGCCTTGCAACATTTTCAAAAGCCTCTTCCGTCTATTATTGACGAAAATCACAATGTGCCG
CAAGCTTTAGAGAATGTTGTTATCCGAGCAACAGCCAAGAAATTGAGTGATCGTTATGGGTCCACTTTTGAGATGAGCCG
TGACTTGATGACGGCGCTTAGCTACAACCGTAGCCGTGAACGTAAAGTCATTTTTGATGATGTGGAAAGCACTAAGCCGC
TTCCCAAAGTAACCCCAACGCCAATGACAACACCAAAAGTTGCGCCGACTCCAGTTACTTCAACAACTGAAAGTAGATTA
GAGCAAACCAATCAAATGGACACGCTCCAAAAGCCACAAAAAAAGAAAAGAAATGGTCGTTTTTTAGGAACCTTATTGAA
GATTCTTTTTTCTCTCTTTATTGTGGGGGTGGCTCTTTTTACTTACTTGGTATTAACTAAGCCAACTTCTGTGAAAGTTC
CTGATGTAACAGGTGTTAGCTTGAAAGTAGCTAAGCAAGAACTACAAGATCTTGGTCTAAAAGTAGGAAAGGTGCGGCAA
ATTGAAAGCGATACTGTCGCTGAAGGAAATGTTGTCCGAACAGACCCACAAGCAGGAACAGCTAAGCGTAAAGGATCAAG
TGTAACTGTTTATTTGTCAATCGGAAATAAAGGTTTTGAAATGGAAAACTACAAAGGGGTTGATTATCAAGATGCTATGA
ACAGCTTGATGGAAACCTATGGCATTCCAAAATCTAAGATTAAAATTGAACGTATTGTGACCAATGAGTATCCTGAAAAT
ACTGTTATTAGCCAGTCACCAAGTGCAGGAGATAAGTTTAATCCCAATGGTAAATCTAAAATTACCCTTAGCGTAGCCGT
TAGTGACACAGTCATTATGCCAATGGTTACAGAATATAGTTATGCTGATGCGGTTAATACTTTGACAGCACTGGGTATTG
ATGCCTCTAGGATAAAAGCTTATGCGCCAAGTTCAAGTTCAGCAACTGGTTTTATTCAGGTTAATTCCCCTAGTTCAAAA
GCTATTGTTAGTGGACAGATGCCTTATTATGGTACGACATTGAGTCTTTCTGAAAAAGGAGAGATAAGCCTTTATCTTTA
TCCAGAAGAAACACACTCTTCAAGTAGTTCCTCAAGTTCAGAATCAAGTTCAAGTAGTTCCTCAACAAGTGATGGCACTG
GGACAAGTAGCAATACCGAATTAAACCCGTCAGAATCGACTGGACAAACACCTTGA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-233)

PASTA domain (PASTA)

(371-433)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(511-587)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2D4DM60

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.529

92.868

0.609
  stkP/pknB Streptococcus salivarius strain HSISS4

62.203

93.502

0.582
  stkP Streptococcus pneumoniae TIGR4

58.221

81.933

0.477
  stkP Streptococcus pneumoniae D39

57.803

82.25

0.475
  stkP Streptococcus pneumoniae R6

57.803

82.25

0.475
  stkP Streptococcus pneumoniae Rx1

57.834

81.933

0.474

Multiple sequence alignment