Detailed information NTG1120085

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: EL070_RS01105
• Genome accession: NZ_LR134284
• Coordinates: 189888..192038 (+)
• Length: 716 a.a.
• NCBI ID: WP_023612228.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8232
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 184888..197038

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL070_RS01085 (NCTC8232_00211)	-	185199..185576 (-)	378	WP_023612231.1	hypothetical protein	-
EL070_RS01090 (NCTC8232_00212)	-	185769..186101 (+)	333	WP_023612241.1	LytR/AlgR family response regulator transcription factor	-
EL070_RS01095 (NCTC8232_00213)	comE/blpR	186110..186847 (+)	738	WP_023612237.1	response regulator transcription factor	Regulator
EL070_RS10130 (NCTC8232_00215)	-	187801..188190 (+)	390	WP_231873482.1	GHKL domain-containing protein	-
EL070_RS09995 (NCTC8232_00216)	-	188261..188404 (-)	144	WP_023612234.1	hypothetical protein	-
EL070_RS10315	-	189178..189309 (+)	132	WP_023612236.1	hypothetical protein	-
EL070_RS01105 (NCTC8232_00218)	comA	189888..192038 (+)	2151	WP_023612228.1	peptide cleavage/export ABC transporter ComA	Regulator
EL070_RS01110 (NCTC8232_00219)	-	192047..193408 (+)	1362	WP_111705438.1	bacteriocin secretion accessory protein	-
EL070_RS01115 (NCTC8232_00220)	-	193550..193723 (+)	174	WP_023612227.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
EL070_RS01120 (NCTC8232_00221)	-	193742..193909 (+)	168	WP_023612226.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
EL070_RS01130 (NCTC8232_00223)	-	194546..195895 (+)	1350	WP_011184137.1	glucose-6-phosphate isomerase	-

Sequence

Protein

• Length: 716 a.a.
• Molecular weight: 80446.43 Da
• Isoelectric Point: 7.1134

>NTDB_id=1120085 EL070_RS01105 WP_023612228.1 189888..192038(+) (comA) [Streptococcus pyogenes strain NCTC8232]
MAFRKKHYRPQVDTRDCGVASLAMVFGYYGSYYSLATLRELAKTTQEGTTAFGLVKVAEGEGFETRAIRADMTLFDEDII
YPFIAHVLKNGNLMHYYVVTGCDKKTIHIADPDPTVKMIKMPRERFEKEWTGVSIFIAPAPSYRIHKEQKDNLLSFLPIL
SRQKGLIVNIVVATLLVTLINIVGSYYLQSIIDTYIPEQVKNTLSIVSVGLVIVYILQQLISYAQEYLLLVLGQRLSIDV
ILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSVIIIVSIVLFSQNINLFFISLLALPIYTVI
ILSFVKPFERMNRETMEANATLSSSIIEDINGIETIKSLTSERQRYQKIDKEFVDYLKKSFAYGKAESTQKTLKKLAQLL
LNVAVLWMGANLVMDNKMSLGQLITYNSLLAYFTNPLENLINLQTKLQTAKVANNRLNEVYLVKSEFEEIKTVNDLSNFK
GHLSFKNVTYRYGYGKDVLTDIDLSIKPGSKVSFVGISGSGKTTLAKMLVNFFSPTKGEILLDDVNLEDIDKESLRRYIN
YLPQQPYVFNGTILDNLLLGAKEGTTQEDILKAVQIAEIKSDIEAMPLNYQTELTSDGSGISGGQRQRIALARALLTGSP
ILILDEATSSLDVLTEKKIIDNLMALDKTLIFIAHRLTISERTEHIVVLDKGNIIEEGNHTELLAKQGFYAHLVNS

Nucleotide

• Length: 2151 bp

>NTDB_id=1120085 EL070_RS01105 WP_023612228.1 189888..192038(+) (comA) [Streptococcus pyogenes strain NCTC8232]
ATGGCATTTCGGAAAAAACATTACCGACCACAGGTAGATACAAGAGACTGCGGTGTTGCCTCTTTGGCTATGGTCTTTGG
CTACTATGGGTCTTACTATTCGCTAGCTACACTTCGAGAGCTCGCAAAGACTACTCAGGAAGGAACAACAGCTTTTGGAT
TGGTCAAAGTTGCCGAAGGGGAGGGGTTTGAAACTCGTGCCATTAGGGCCGATATGACCTTATTTGACGAGGATATTATC
TATCCTTTTATCGCCCACGTGCTTAAGAATGGCAATCTCATGCACTATTATGTGGTCACAGGTTGTGATAAAAAGACCAT
TCACATCGCAGACCCAGATCCTACGGTTAAAATGATTAAAATGCCTCGGGAGCGTTTTGAAAAGGAGTGGACAGGAGTTT
CTATTTTTATTGCTCCTGCGCCCAGTTACAGAATCCATAAGGAACAAAAGGACAATCTACTTTCCTTCTTGCCAATTTTA
TCTCGTCAAAAAGGCTTGATTGTCAATATTGTTGTAGCTACCTTATTGGTCACCTTAATTAATATTGTTGGCTCATACTA
CTTGCAGTCTATTATTGATACCTATATTCCAGAGCAGGTAAAAAACACATTAAGTATTGTTTCTGTAGGACTTGTAATTG
TTTATATCTTGCAGCAATTGATTTCTTATGCCCAGGAGTATTTACTTTTAGTTCTTGGTCAGAGGCTCTCTATTGACGTT
ATTCTATCCTATATTAAGCATGTTTTCCATCTTCCAATGTCATTCTTTGCGACAAGAAGAACAGGGGAAATAGTATCACG
TTTTACAGATGCAAATTCTATTATTGATGCTTTGGCAAGCACAATTTTATCTATTTTCTTAGATGTCTCAGTCATCATTA
TTGTATCGATAGTGTTATTCTCTCAAAACATTAACCTCTTTTTCATTAGTTTATTAGCTTTACCAATTTATACTGTGATT
ATTCTTTCGTTCGTGAAACCTTTTGAGCGTATGAATCGGGAAACTATGGAAGCTAATGCTACCCTATCTTCTTCAATTAT
TGAAGATATCAATGGTATTGAGACCATTAAATCATTAACAAGTGAAAGGCAACGTTACCAAAAAATTGATAAAGAGTTTG
TTGATTACTTGAAAAAATCTTTTGCTTATGGTAAAGCTGAAAGTACTCAAAAAACATTGAAAAAATTAGCTCAATTGTTA
CTTAATGTAGCCGTTCTTTGGATGGGAGCTAATCTAGTTATGGATAATAAGATGTCACTTGGTCAATTGATTACTTATAA
CTCTTTACTAGCATACTTCACAAACCCATTAGAAAATCTTATAAACCTTCAGACAAAATTACAAACAGCTAAAGTTGCCA
ATAATCGTTTAAATGAAGTGTATCTTGTGAAATCAGAATTTGAGGAGATAAAAACAGTTAATGATTTAAGCAATTTTAAG
GGTCATTTATCGTTTAAAAATGTTACATATCGCTATGGATACGGAAAAGATGTCCTAACAGATATTGATTTAAGTATAAA
GCCTGGTAGTAAAGTATCTTTTGTTGGGATATCAGGCTCGGGAAAAACAACCTTGGCTAAAATGTTAGTCAATTTCTTTA
GTCCTACTAAGGGAGAGATATTATTGGATGATGTGAACTTAGAAGATATTGATAAAGAAAGTCTACGTCGTTATATCAAC
TATCTCCCACAACAGCCATATGTATTTAATGGAACAATTTTGGATAATCTTTTATTAGGTGCTAAAGAAGGAACAACCCA
AGAAGATATTTTAAAAGCTGTTCAGATTGCTGAAATTAAGTCAGATATCGAAGCTATGCCACTCAATTATCAAACAGAAT
TGACATCGGATGGTTCAGGTATATCAGGCGGGCAACGTCAACGTATTGCTTTGGCACGTGCTTTATTGACAGGTTCTCCA
ATTCTTATTCTAGATGAGGCAACAAGCAGCTTAGATGTTTTAACAGAAAAGAAAATTATTGATAATCTCATGGCGCTAGA
TAAAACATTGATATTCATTGCTCATAGACTAACGATTTCAGAGAGAACTGAACATATCGTGGTACTGGATAAAGGTAATA
TTATTGAAGAAGGGAACCACACGGAGTTGTTAGCTAAACAAGGTTTCTATGCCCATCTTGTCAATAGTTAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-437)

• Peptidase C39 family (Peptidase_C39) (6-141)

• ABC transporter (ABC_tran) (499-649)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	80.614	100	0.807
comA	Streptococcus mitis SK321	80.056	100	0.802
comA	Streptococcus pneumoniae Rx1	79.916	100	0.8
comA	Streptococcus pneumoniae D39	79.916	100	0.8
comA	Streptococcus pneumoniae R6	79.916	100	0.8
comA	Streptococcus pneumoniae TIGR4	79.637	100	0.797
comA	Streptococcus gordonii str. Challis substr. CH1	75.314	100	0.754
comA/nlmT	Streptococcus mutans UA159	63.04	100	0.631