Detailed information NTG1120074

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EL070_RS00340
• Genome accession: NZ_LR134284
• Coordinates: 54276..55187 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8232
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 49276..60187

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL070_RS00320 (NCTC8232_00063)	purE	49858..50349 (+)	492	WP_111705414.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
EL070_RS00325 (NCTC8232_00064)	purK	50336..51409 (+)	1074	WP_164552673.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EL070_RS00330 (NCTC8232_00065)	-	51411..52829 (+)	1419	WP_011888524.1	hypothetical protein	-
EL070_RS00335 (NCTC8232_00066)	purB	52849..54141 (+)	1293	WP_111705416.1	adenylosuccinate lyase	-
EL070_RS00340 (NCTC8232_00067)	comR	54276..55187 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
EL070_RS10455 (NCTC8232_00068)	comS	55272..55367 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
EL070_RS00345 (NCTC8232_00069)	ruvB	55414..56412 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
EL070_RS00350 (NCTC8232_00070)	-	56550..56987 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
EL070_RS00355 (NCTC8232_00071)	-	57010..57411 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
EL070_RS00360 (NCTC8232_00072)	-	57408..59183 (+)	1776	WP_111705417.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1120074 EL070_RS00340 WP_002986681.1 54276..55187(+) (comR) [Streptococcus pyogenes strain NCTC8232]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1120074 EL070_RS00340 WP_002986681.1 54276..55187(+) (comR) [Streptococcus pyogenes strain NCTC8232]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462