Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EL079_RS07395 Genome accession   NZ_LR134283
Coordinates   1498606..1499796 (-) Length   396 a.a.
NCBI ID   WP_003032033.1    Uniprot ID   I0S836
Organism   Streptococcus anginosus strain NCTC10713     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1493606..1504796
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL079_RS07370 (NCTC10713_01516) - 1494198..1494698 (+) 501 WP_003032448.1 YehR family lipoprotein -
  EL079_RS07375 (NCTC10713_01517) - 1494722..1494919 (-) 198 WP_003032456.1 DUF951 domain-containing protein -
  EL079_RS07380 (NCTC10713_01518) dnaN 1494919..1496055 (-) 1137 WP_003032449.1 DNA polymerase III subunit beta -
  EL079_RS07385 (NCTC10713_01519) dnaA 1496212..1497555 (-) 1344 WP_003032031.1 chromosomal replication initiator protein DnaA -
  EL079_RS07390 (NCTC10713_01520) spo0J 1497784..1498551 (-) 768 WP_003032028.1 ParB/RepB/Spo0J family partition protein Regulator
  EL079_RS07395 (NCTC10713_01521) htrA 1498606..1499796 (-) 1191 WP_003032033.1 S1C family serine protease Regulator
  EL079_RS07400 (NCTC10713_01522) rlmH 1499990..1500469 (+) 480 WP_003032032.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EL079_RS07410 (NCTC10713_01524) - 1500751..1500897 (+) 147 WP_003029519.1 bacteriocin -
  EL079_RS07415 (NCTC10713_01525) comD/comD2 1500918..1502240 (+) 1323 WP_221739197.1 GHKL domain-containing protein Regulator
  EL079_RS07420 (NCTC10713_01526) comE 1502240..1502989 (+) 750 WP_018543656.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41651.61 Da        Isoelectric Point: 9.4264

>NTDB_id=1120046 EL079_RS07395 WP_003032033.1 1498606..1499796(-) (htrA) [Streptococcus anginosus strain NCTC10713]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=1120046 EL079_RS07395 WP_003032033.1 1498606..1499796(-) (htrA) [Streptococcus anginosus strain NCTC10713]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTGAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGCGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0S836

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

75.561

100

0.765
  htrA Streptococcus mitis NCTC 12261

72.544

100

0.727
  htrA Streptococcus pneumoniae Rx1

72.292

100

0.725
  htrA Streptococcus pneumoniae D39

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.292

100

0.725
  htrA Streptococcus pneumoniae TIGR4

72.292

100

0.725
  htrA Streptococcus mutans UA159

55.471

99.242

0.551

Multiple sequence alignment