Detailed information NTG1120026

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: EL079_RS04735
• Genome accession: NZ_LR134283
• Coordinates: 976398..978575 (+)
• Length: 725 a.a.
• NCBI ID: WP_003030689.1
• Uniprot ID: A0A448AI45
• Organism: Streptococcus anginosus strain NCTC10713
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 971398..983575

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL079_RS04705 (NCTC10713_00984)	arcA	971417..972646 (-)	1230	WP_003028185.1	arginine deiminase	-
EL079_RS04710 (NCTC10713_00985)	-	972956..973642 (-)	687	WP_018543437.1	Crp/Fnr family transcriptional regulator	-
EL079_RS04715 (NCTC10713_00986)	-	973779..974837 (-)	1059	WP_018543436.1	serine hydrolase	-
EL079_RS04720 (NCTC10713_00987)	-	975052..975381 (-)	330	WP_003030698.1	hypothetical protein	-
EL079_RS04725 (NCTC10713_00988)	-	975433..975684 (-)	252	WP_018543435.1	hypothetical protein	-
EL079_RS04730 (NCTC10713_00989)	-	975866..976150 (-)	285	WP_003030694.1	bacteriocin immunity protein	-
EL079_RS04735 (NCTC10713_00990)	comA/nlmT	976398..978575 (+)	2178	WP_003030689.1	peptide cleavage/export ABC transporter	Regulator
EL079_RS04740 (NCTC10713_00991)	-	978586..979947 (+)	1362	WP_003030685.1	bacteriocin secretion accessory protein	-
EL079_RS04745 (NCTC10713_00992)	-	980222..980827 (-)	606	WP_003025442.1	superoxide dismutase	-
EL079_RS04750 (NCTC10713_00993)	holA	980898..981935 (-)	1038	WP_003030703.1	DNA polymerase III subunit delta	-
EL079_RS04755 (NCTC10713_00994)	cvfB	982017..982871 (-)	855	WP_003030696.1	RNA-binding virulence regulatory protein CvfB	-

Sequence

Protein

• Length: 725 a.a.
• Molecular weight: 81628.28 Da
• Isoelectric Point: 9.4585

>NTDB_id=1120026 EL079_RS04735 WP_003030689.1 976398..978575(+) (comA/nlmT) [Streptococcus anginosus strain NCTC10713]
MNLKKSFVPQIDARDCGIAALASIARYYGSNYSLAHLRELAKTDKEGTTALGIVKAAKEMGFETRPIQADMTLFDTEELP
YPFIVHINKNGNLQHYYVVYKNEKKHLLIGDPDPTVKITKISKEQFITKISKEQFAKDWTGVAIFLAPKPSYKPHKDKKN
GLASFLPLIFKQRSLIFYIVLASLLVTLINIVGSYYLQGVLDEYIPNQMKSTLGIISIGLIIAYILQQMMSFSRDYLLTV
LSQRLTIDVILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDLSIVMIVGNVLLLQNTNLFLLTL
LAIPIYALIIFAFMKPFEKMNNDVMQSNAMVNSAIIEDINGIETIKSLTSEESRYQKIDSEFVDYLDKTFKLSKYSIMQT
ALKQGAQLILNVVILWVGASLVMSQKISIGQLITFNTLLSYFTSPLESIINLQTKLQSAKVANHRLNEVYLVESEFKTKQ
VLTEKRFLAGDITFHNVSYKYGFGRDTLSDISLTIKKGDKISLVGISGSGKTTLAKMIVHFYEPYQGQIRLNGNDLKTID
KKVLRQYINYLPQQAYIFSGSILENLTLGADQTVSQSDILRACEIAEIRSDIEQMPMGYQTELSDGAGLSGGQKQRIALA
RALLTKSPILILDEATSGLDVLTEKKVIDNLMKLPDKTIIFVAHRLSISKRTNQIIVLDQGKVIETGSHTELIERKGFYY
HLFNK

Nucleotide

• Length: 2178 bp

>NTDB_id=1120026 EL079_RS04735 WP_003030689.1 976398..978575(+) (comA/nlmT) [Streptococcus anginosus strain NCTC10713]
GTGAATTTAAAAAAATCGTTTGTGCCGCAAATAGATGCTAGAGATTGTGGTATTGCTGCTCTGGCTTCCATTGCTAGATA
CTATGGTTCAAATTATTCTTTAGCACACTTGAGAGAGCTCGCAAAGACAGACAAAGAAGGGACAACTGCACTTGGAATTG
TCAAAGCAGCAAAAGAAATGGGCTTTGAAACCCGACCAATCCAAGCAGATATGACATTGTTTGATACAGAAGAGCTTCCC
TATCCTTTCATCGTACATATCAATAAAAACGGCAACCTTCAGCACTATTATGTTGTTTATAAAAACGAGAAAAAGCACTT
GCTTATCGGTGATCCTGATCCAACTGTCAAAATAACTAAGATTAGCAAAGAACAATTTATAACTAAGATTAGCAAAGAAC
AATTTGCAAAAGATTGGACTGGTGTTGCTATCTTTCTCGCACCGAAACCTAGCTATAAACCTCATAAGGATAAGAAGAAC
GGGCTTGCTAGCTTTTTACCACTCATCTTTAAACAGCGTTCTTTGATTTTTTATATTGTCTTAGCTAGTTTGCTCGTGAC
CCTCATCAACATTGTGGGCTCCTATTATCTGCAAGGTGTTTTGGACGAATACATCCCAAATCAGATGAAATCAACTCTTG
GGATTATTTCAATTGGGCTTATCATTGCCTACATCTTACAGCAAATGATGAGTTTTTCAAGAGACTACCTGCTAACAGTG
CTCAGTCAACGATTAACAATTGATGTGATTTTGTCTTATATTCGGCATATTTTTGAATTACCAATGTCCTTTTTTGCGAC
GAGACGCACTGGGGAGATTATTTCTCGTTTTACAGATGCCAACTCCATTATTGATGCTCTAGCTTCAACTATCCTGTCTC
TCTTTCTTGATTTGTCCATTGTGATGATTGTCGGCAATGTTCTTTTACTGCAAAATACCAATCTCTTTTTACTCACCTTG
CTTGCAATTCCTATCTACGCTCTCATTATTTTTGCTTTTATGAAGCCTTTTGAAAAAATGAATAACGATGTTATGCAAAG
CAATGCTATGGTAAATTCTGCCATTATCGAAGATATCAACGGAATTGAAACCATTAAATCTTTAACCAGCGAAGAAAGCC
GTTACCAAAAGATTGATAGCGAGTTTGTTGATTATCTGGATAAGACTTTCAAGTTAAGTAAATATTCTATTATGCAGACA
GCACTCAAACAAGGAGCACAACTTATTTTGAATGTGGTCATTCTCTGGGTTGGAGCTTCTTTAGTCATGTCTCAAAAGAT
TTCAATTGGTCAGCTGATTACTTTCAATACTCTCCTTTCATACTTTACTAGTCCGCTTGAAAGTATTATCAATCTTCAAA
CCAAACTGCAATCAGCTAAAGTTGCCAATCATCGACTGAATGAAGTTTATCTGGTAGAATCCGAATTCAAAACCAAGCAA
GTCCTTACGGAGAAAAGATTCTTAGCTGGAGACATTACTTTCCATAACGTCTCCTATAAATACGGCTTTGGACGAGATAC
TTTATCAGATATTAGTTTGACTATCAAGAAAGGAGATAAAATCAGTCTTGTCGGCATCAGTGGTTCGGGAAAAACAACAC
TTGCTAAGATGATTGTTCATTTTTATGAGCCTTATCAAGGACAAATTCGCCTCAACGGAAATGACCTCAAGACAATTGAT
AAGAAAGTTCTTCGGCAATATATCAACTACCTGCCTCAGCAAGCTTACATCTTTAGCGGCTCCATTCTAGAAAACCTCAC
ATTAGGAGCCGATCAAACAGTTTCTCAATCAGACATTCTTCGTGCCTGTGAAATTGCAGAAATTCGTTCAGATATCGAAC
AAATGCCCATGGGATACCAGACAGAATTGTCTGACGGAGCTGGATTATCTGGTGGGCAAAAACAGCGAATCGCACTTGCA
CGCGCTCTGCTGACGAAATCTCCCATTCTCATTTTAGATGAAGCAACGAGTGGATTAGATGTTCTAACAGAGAAAAAAGT
CATTGATAATCTCATGAAATTACCCGACAAAACCATTATTTTTGTTGCTCATCGTCTCAGCATTTCAAAGCGTACAAATC
AGATTATCGTCCTTGACCAAGGAAAAGTGATTGAAACTGGTTCTCATACTGAATTGATAGAAAGAAAAGGTTTTTATTAT
CATCTATTTAATAAATAA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (508-657)

• ABC transporter transmembrane region (ABC_membrane) (176-446)

• Peptidase C39 family (Peptidase_C39) (5-150)

3D structure

• AlphaFold DB: A0A448AI45

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.006	99.034	0.713
comA	Streptococcus mitis NCTC 12261	66.62	99.586	0.663
comA	Streptococcus mitis SK321	66.482	99.586	0.662
comA	Streptococcus gordonii str. Challis substr. CH1	66.343	99.586	0.661
comA	Streptococcus pneumoniae D39	65.928	99.586	0.657
comA	Streptococcus pneumoniae R6	65.928	99.586	0.657
comA	Streptococcus pneumoniae Rx1	65.928	99.586	0.657
comA	Streptococcus pneumoniae TIGR4	65.512	99.586	0.652