Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   EL078_RS02305 Genome accession   NZ_LR134282
Coordinates   433642..435528 (+) Length   628 a.a.
NCBI ID   WP_126437631.1    Uniprot ID   -
Organism   Streptococcus equinus strain NCTC8140     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 428642..440528
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL078_RS02290 (NCTC8140_00459) fmt 430620..431555 (+) 936 WP_126437629.1 methionyl-tRNA formyltransferase -
  EL078_RS02295 (NCTC8140_00460) rsmB 431545..432867 (+) 1323 WP_126437630.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  EL078_RS02300 (NCTC8140_00461) - 432905..433642 (+) 738 WP_024344649.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  EL078_RS02305 (NCTC8140_00462) pknB 433642..435528 (+) 1887 WP_126437631.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EL078_RS02310 (NCTC8140_00463) liaF 435626..436321 (+) 696 WP_027968110.1 cell wall-active antibiotics response protein LiaF -
  EL078_RS02315 (NCTC8140_00464) - 436318..437343 (+) 1026 WP_024344652.1 sensor histidine kinase -
  EL078_RS02320 (NCTC8140_00465) - 437327..437971 (+) 645 WP_024344653.1 response regulator transcription factor -
  EL078_RS02325 (NCTC8140_00466) - 438095..439495 (+) 1401 WP_029876003.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  EL078_RS02330 (NCTC8140_00467) - 439495..439851 (+) 357 WP_027968108.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 628 a.a.        Molecular weight: 68603.33 Da        Isoelectric Point: 5.9292

>NTDB_id=1119964 EL078_RS02305 WP_126437631.1 433642..435528(+) (pknB) [Streptococcus equinus strain NCTC8140]
MIQIGKLFAGRYRILKSIGRGGMADVYLAKDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKDGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENKNVP
QALENVVIKATAKRLSDRYASTFEMSRDLMTALSYNRSRERKLVFEDTENTKTLPKVTTSTPVPSTTEQLLKKQKAAKEN
KEVANQKAPKAKAKKKKSHRMFGTLMKIFFAVVVVAIAIFTYLTLSTPASVNVPDVSGAALSDAKTSLTSAGFKVGKIKE
IYSDTVPSGQVIETNPKAGTSKKEGSRVDIYVSSSELDDYTGQNYQEVIKKLGDKYGISNSAITIHWNDETSQKGGTVIS
QTPEKGTKVGSKSEVTLTVAAYTMPNLIGYTYQDAIAELTNLGILKSDITIYQADINSSSEYSQVKTPSASSVVVAQEPY
FGAAFKGSVKLYFSSESVFSSYETVPSQSIPEESESSETSETSESSSSSSSSSSTEESSQTDSSSVEQ

Nucleotide


Download         Length: 1887 bp        

>NTDB_id=1119964 EL078_RS02305 WP_126437631.1 433642..435528(+) (pknB) [Streptococcus equinus strain NCTC8140]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGTATCCTTAAATCAATCGGACGGGGTGGAATGGCAGATGTTTA
TCTTGCCAAAGATCTGATTCTTGATAATGAAGAAGTAGCCATCAAAGTTCTTCGGACTAATTATCAAACAGATCAAATTG
CCGTAGCTCGTTTCCAACGTGAAGCGCGCGCCATGGCAGAGTTGAACCATCCCAATATTGTTTCGATTCGAGATATTGGA
GAAGAAGACGGACAGCAATTCTTAGTAATGGAATATGTTGATGGTTCTGACTTGAAAAAATACATTCAAGATCATGCGCC
TCTATCTAATAACGAAGTTGTTAGAATTATGGAAGAAGTCTTGTCAGCAATGACTCTTGCCCATCAACAAGGAATTGTTC
ACCGTGACTTAAAACCACAAAATATTTTGTTGACCAAAGACGGAACTGTAAAAGTTACTGACTTTGGTATTGCTGTAGCT
TTTGCAGAAACAAGTTTAACACAGACAAACTCAATGCTTGGTAGTGTGCATTATTTGTCACCTGAACAAGCGCGCGGTTC
AAAAGCCACTGTTCAAAGTGATATCTATGCTATGGGGATTATGTTGTTTGAAATGTTAACAGGTCACATTCCTTATGATG
GGGATTCAGCTGTTACCATTGCTTTGCAACATTTCCAAAAACCACTTCCATCAATCATTGATGAAAACAAAAATGTTCCT
CAAGCTTTGGAAAATGTAGTTATCAAAGCAACAGCAAAACGTTTAAGCGACCGTTATGCATCAACGTTTGAAATGAGTCG
TGATTTGATGACGGCACTTTCATACAACCGTAGTCGAGAACGTAAACTTGTTTTTGAGGATACAGAAAATACTAAGACAC
TTCCAAAAGTGACTACTTCAACACCTGTTCCATCAACGACAGAACAATTGTTGAAAAAACAAAAAGCTGCAAAAGAAAAT
AAAGAAGTAGCTAATCAAAAAGCACCTAAAGCAAAGGCTAAAAAGAAAAAATCTCATCGTATGTTTGGTACTTTGATGAA
AATCTTCTTTGCAGTCGTTGTTGTTGCGATTGCTATCTTTACATACCTAACTTTAAGTACACCAGCTTCAGTTAATGTTC
CAGATGTATCTGGTGCGGCTTTATCTGATGCTAAGACAAGTCTTACATCAGCAGGGTTTAAAGTTGGAAAAATCAAGGAA
ATTTATAGTGATACTGTTCCAAGTGGTCAGGTTATTGAGACTAATCCGAAAGCTGGCACATCTAAGAAAGAAGGGTCTAG
AGTTGATATCTATGTTTCAAGTTCTGAGTTGGATGATTATACTGGTCAAAATTATCAAGAAGTTATTAAAAAACTTGGAG
ACAAATATGGTATCTCAAATAGTGCTATTACGATTCATTGGAACGACGAAACTAGTCAGAAAGGTGGTACTGTTATTAGT
CAAACCCCTGAAAAGGGGACAAAAGTTGGTAGCAAGAGTGAAGTTACTTTAACGGTTGCGGCTTATACTATGCCTAATCT
GATTGGTTACACTTATCAAGATGCTATTGCTGAATTGACGAATCTTGGAATACTAAAATCTGATATCACAATATATCAAG
CAGATATCAATTCTTCATCAGAATATTCTCAAGTTAAAACGCCATCTGCATCGTCAGTTGTTGTGGCACAAGAACCTTAC
TTTGGTGCAGCTTTTAAAGGAAGCGTGAAACTTTATTTTTCATCTGAAAGTGTTTTTTCTTCTTATGAAACAGTACCTTC
CCAATCTATTCCTGAAGAGTCTGAGTCATCTGAGACAAGTGAAACTAGTGAGTCAAGTTCTTCAAGTAGCAGCAGTAGCA
GCACTGAAGAAAGTTCACAAACCGACTCATCATCAGTTGAACAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(503-574)

PASTA domain (PASTA)

(371-433)

PASTA domain (PASTA)

(436-500)

Protein kinase domain (Pkinase)

(12-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.845

90.446

0.596
  stkP/pknB Streptococcus salivarius strain HSISS4

62.988

93.79

0.591
  stkP Streptococcus pneumoniae TIGR4

58.004

84.554

0.49
  stkP Streptococcus pneumoniae D39

57.815

84.554

0.489
  stkP Streptococcus pneumoniae R6

57.815

84.554

0.489
  stkP Streptococcus pneumoniae Rx1

57.627

84.554

0.487

Multiple sequence alignment