Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EL086_RS01235 Genome accession   NZ_LR134274
Coordinates   230601..231350 (+) Length   249 a.a.
NCBI ID   WP_014633817.1    Uniprot ID   A0AB35IU89
Organism   Streptococcus salivarius strain NCTC8618     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 225601..236350
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL086_RS01210 (NCTC8618_02652) - 225771..226541 (+) 771 WP_038675188.1 membrane protein -
  EL086_RS01215 (NCTC8618_02653) - 226616..227356 (-) 741 WP_002886432.1 amino acid ABC transporter ATP-binding protein -
  EL086_RS01220 (NCTC8618_02654) - 227356..228903 (-) 1548 WP_022496531.1 ABC transporter substrate-binding protein/permease -
  EL086_RS01225 (NCTC8618_02655) - 229109..229963 (+) 855 WP_002883622.1 undecaprenyl-diphosphate phosphatase -
  EL086_RS01230 (NCTC8618_02656) - 230023..230394 (-) 372 WP_002886434.1 DUF3021 family protein -
  EL086_RS01235 (NCTC8618_02657) mecA 230601..231350 (+) 750 WP_014633817.1 adaptor protein MecA Regulator
  EL086_RS01240 (NCTC8618_02658) - 231354..232511 (+) 1158 WP_038675191.1 glycosyltransferase family 4 protein -
  EL086_RS01245 (NCTC8618_02659) sufC 232674..233444 (+) 771 WP_038675193.1 Fe-S cluster assembly ATPase SufC -
  EL086_RS01250 (NCTC8618_02660) sufD 233481..234743 (+) 1263 WP_038675195.1 Fe-S cluster assembly protein SufD -
  EL086_RS01255 (NCTC8618_02661) - 234797..236029 (+) 1233 WP_037611136.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29100.68 Da        Isoelectric Point: 4.0182

>NTDB_id=1119796 EL086_RS01235 WP_014633817.1 230601..231350(+) (mecA) [Streptococcus salivarius strain NCTC8618]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMDDYSGLSPEEFLKALEGNFMDKGDIEAHHKLEELEKTLEEVDKAMTEPTKEVAEENIREDYTHYVLAF
SDFDQVVTFTQGLKDIPVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRAYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1119796 EL086_RS01235 WP_014633817.1 230601..231350(+) (mecA) [Streptococcus salivarius strain NCTC8618]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAATT
GAAGGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGCTGAGCTTCCGTGTCACGCCACGCAAGGATCGTGTGGATGTCTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAACGATTTGTCAGATATGGATGACTACTCAGGGCTTTCTCCAGAAGAGTTCCTCAAGGCTCT
TGAGGGTAACTTTATGGACAAGGGTGACATCGAAGCACACCATAAGCTCGAAGAGCTTGAAAAGACCTTGGAAGAGGTTG
ATAAGGCTATGACAGAGCCTACCAAGGAAGTGGCTGAAGAAAATATTCGTGAAGACTATACCCACTATGTCTTGGCCTTC
TCTGACTTTGATCAAGTGGTGACTTTTACGCAAGGTTTGAAGGATATACCTGTTGAAGGTTCTGAGCTTTATAAGCTGGG
GGATGTCTACTACATGACGATTCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTGCCTACCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTACTACAAGCAACGAAATGGAGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

93.976

100

0.94
  mecA Streptococcus thermophilus LMG 18311

93.173

100

0.932
  mecA Streptococcus mutans UA159

60.246

97.992

0.59
  mecA Streptococcus pneumoniae Rx1

47.39

100

0.474
  mecA Streptococcus pneumoniae D39

47.39

100

0.474
  mecA Streptococcus pneumoniae R6

47.39

100

0.474
  mecA Streptococcus pneumoniae TIGR4

47.39

100

0.474

Multiple sequence alignment