Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   EL071_RS10910 Genome accession   NZ_LR134265
Coordinates   2103731..2105686 (-) Length   651 a.a.
NCBI ID   WP_115356978.1    Uniprot ID   -
Organism   Streptococcus agalactiae strain NCTC8184     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 2098731..2110686
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL071_RS10885 (NCTC8184_02169) - 2098924..2100288 (-) 1365 WP_277871463.1 Cof-type HAD-IIB family hydrolase -
  EL071_RS10890 - 2100308..2101113 (+) 806 WP_115356725.1 IS5 family transposase -
  EL071_RS10895 (NCTC8184_02172) - 2101227..2101868 (-) 642 WP_000357891.1 response regulator transcription factor -
  EL071_RS10900 (NCTC8184_02173) - 2101861..2102880 (-) 1020 WP_000716168.1 sensor histidine kinase -
  EL071_RS10905 (NCTC8184_02174) liaF 2102877..2103572 (-) 696 WP_000714456.1 cell wall-active antibiotics response protein LiaF -
  EL071_RS10910 (NCTC8184_02175) pknB 2103731..2105686 (-) 1956 WP_115356978.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EL071_RS10915 (NCTC8184_02176) - 2105686..2106423 (-) 738 WP_000406233.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  EL071_RS10920 (NCTC8184_02177) rsmB 2106461..2107783 (-) 1323 WP_001262601.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  EL071_RS10925 (NCTC8184_02178) fmt 2107773..2108708 (-) 936 WP_000163893.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 651 a.a.        Molecular weight: 70849.63 Da        Isoelectric Point: 9.6759

>NTDB_id=1119530 EL071_RS10910 WP_115356978.1 2103731..2105686(-) (pknB) [Streptococcus agalactiae strain NCTC8184]
MIQIGKLFAGRYRILKSIGRGGMADVYLARDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELTHPNIVAIHDIG
EEDGQQFLVMEYVDGFDLKKYIQDNAPLSNNEVVRIMNEVLSAMSLAHQKGIVHRDLKPQNILLTKKGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSILAENKSVP
QALENIVIKATAKKLTDRYKTTYEMGRDLSTALSSTRHREPKLVFNDTESTKTLPKVTSTVSSLTTEQLLRNQKQAKTTE
KITPDSASNDKTKSKKKASHRLLGTIMKLFFALCVVGIIVFAYKILVSPTTIRVPDVSNKTVAQAKMTLENSGLKVGAIR
NIESDSVSEGLVVKTDPAAGRSRREGAKVNLYIATPNKSFTLGNYKEHNYKDILKDLQGKGVKKSLIKVKRKINNDYTTG
TILAQSLPEGTSFNPDGNKKLTLTVAVNDPMIMPDVTGMTVGEVIETLTDLGLDADNLVFYQMQNGVYQAVVTPPSSSKI
ASQDPYYGGEVGLRRGDKVKLYLLGSKTTNNSSSTPIDSSASSSTGTTTSDSVSSSTDASTSDSSSTSTSSSTLPSDSTT
NTRTANNPLTQ

Nucleotide


Download         Length: 1956 bp        

>NTDB_id=1119530 EL071_RS10910 WP_115356978.1 2103731..2105686(-) (pknB) [Streptococcus agalactiae strain NCTC8184]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATCCTTAAATCAATCGGACGAGGTGGAATGGCGGATGTTTA
TCTAGCTCGAGATCTAATTTTAGATAATGAAGAGGTCGCAATAAAAGTATTGCGAACCAATTATCAAACAGATCAGATTG
CGGTTGCTCGCTTCCAGAGAGAAGCACGAGCAATGGCTGAGCTGACACATCCTAATATTGTCGCTATTCATGATATAGGT
GAAGAAGACGGACAGCAGTTCTTAGTAATGGAATATGTTGATGGATTCGATTTAAAAAAGTATATTCAAGACAATGCACC
CCTATCAAATAATGAAGTTGTTCGAATCATGAATGAAGTCCTTTCAGCCATGTCACTGGCACATCAGAAAGGTATCGTAC
ACCGTGATTTAAAACCTCAAAATATTTTATTAACTAAAAAAGGGACTGTAAAAGTTACAGATTTCGGTATTGCGGTAGCG
TTTGCTGAAACTAGTTTAACGCAAACGAATTCTATGTTAGGTAGTGTTCATTATTTATCGCCAGAGCAGGCGCGTGGTTC
AAAAGCGACTGTTCAGAGTGATATTTATGCCATGGGAATCATGCTTTTTGAAATGTTAACTGGCCATATTCCTTATGATG
GGGATAGTGCAGTTACTATTGCCCTACAGCACTTCCAAAAACCACTACCATCAATCCTTGCAGAAAATAAAAGCGTTCCA
CAAGCTTTGGAAAACATTGTCATTAAAGCAACAGCTAAAAAGCTAACAGATCGCTATAAGACAACTTATGAGATGGGACG
TGATTTATCAACTGCTCTAAGCTCGACACGTCACCGTGAACCAAAACTTGTTTTTAATGATACTGAGAGTACTAAGACAC
TACCAAAAGTAACATCTACAGTATCATCTTTAACGACAGAACAACTGTTGCGTAATCAAAAACAGGCCAAAACAACAGAA
AAAATAACTCCTGATTCTGCGAGTAACGATAAAACGAAGTCTAAAAAGAAGGCTTCTCATCGACTTCTTGGTACAATCAT
GAAATTATTCTTTGCACTCTGTGTTGTAGGAATAATTGTATTTGCTTATAAAATTTTAGTAAGTCCTACGACTATTCGTG
TTCCAGATGTTAGCAACAAAACAGTAGCTCAAGCAAAAATGACATTGGAAAATTCTGGATTGAAAGTAGGAGCTATTCGT
AATATTGAGAGTGATAGTGTTTCAGAAGGCCTTGTCGTAAAAACAGACCCTGCTGCAGGACGTTCTCGTAGAGAAGGGGC
TAAAGTTAATCTTTATATTGCCACTCCAAACAAGAGTTTCACTCTAGGTAATTATAAGGAACATAATTACAAAGATATCC
TCAAAGATCTTCAAGGCAAAGGTGTTAAAAAATCTTTAATCAAGGTTAAGCGTAAAATTAATAATGATTATACTACTGGT
ACAATCTTAGCACAGTCGCTTCCAGAAGGAACATCTTTTAATCCTGATGGTAATAAGAAATTAACACTTACGGTTGCTGT
TAATGATCCAATGATTATGCCTGATGTAACAGGTATGACAGTTGGAGAAGTAATAGAAACCTTGACAGACCTCGGATTAG
ATGCAGATAATCTTGTCTTCTATCAAATGCAAAATGGCGTTTATCAAGCAGTAGTAACACCTCCATCTTCAAGTAAGATA
GCAAGTCAGGATCCTTATTACGGAGGAGAAGTTGGATTAAGGAGAGGAGATAAAGTTAAGCTGTATCTTCTTGGTTCTAA
AACAACAAATAACTCATCATCTACGCCAATAGATTCTTCGGCTTCAAGCTCAACAGGAACAACTACCTCGGATTCTGTAA
GCTCATCAACGGATGCTAGCACTTCTGATAGTAGTAGCACTTCTACAAGTAGTTCAACACTACCAAGTGATAGTACAACT
AATACAAGAACAGCTAACAATCCATTAACTCAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(511-583)

PASTA domain (PASTA)

(373-434)

PASTA domain (PASTA)

(441-506)

Protein kinase domain (Pkinase)

(12-254)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

60.788

89.708

0.545
  stkP/pknB Streptococcus salivarius strain HSISS4

60.727

88.786

0.539
  stkP Streptococcus pneumoniae TIGR4

59.612

79.109

0.472
  stkP Streptococcus pneumoniae D39

59.417

79.109

0.47
  stkP Streptococcus pneumoniae R6

59.417

79.109

0.47
  stkP Streptococcus pneumoniae Rx1

59.223

79.109

0.469

Multiple sequence alignment