Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   EL071_RS08860 Genome accession   NZ_LR134265
Coordinates   1723857..1724567 (-) Length   236 a.a.
NCBI ID   WP_000722052.1    Uniprot ID   X5K3L1
Organism   Streptococcus agalactiae strain NCTC8184     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1718857..1729567
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL071_RS08840 (NCTC8184_01758) rnc 1720470..1721156 (-) 687 WP_115356862.1 ribonuclease III -
  EL071_RS08845 (NCTC8184_01759) - 1721331..1721699 (-) 369 WP_000719384.1 YbaN family protein -
  EL071_RS08850 (NCTC8184_01760) vicX 1721702..1722511 (-) 810 WP_001289498.1 MBL fold metallo-hydrolase Regulator
  EL071_RS08855 (NCTC8184_01761) vicK 1722515..1723864 (-) 1350 WP_001065465.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EL071_RS08860 (NCTC8184_01762) vicR 1723857..1724567 (-) 711 WP_000722052.1 response regulator YycF Regulator
  EL071_RS08865 (NCTC8184_01763) - 1724907..1725662 (+) 756 WP_000053146.1 amino acid ABC transporter ATP-binding protein -
  EL071_RS08870 (NCTC8184_01764) - 1725674..1726474 (+) 801 WP_000946173.1 transporter substrate-binding domain-containing protein -
  EL071_RS08875 (NCTC8184_01765) - 1726487..1727182 (+) 696 WP_000173638.1 amino acid ABC transporter permease -
  EL071_RS08880 (NCTC8184_01766) - 1727194..1727844 (+) 651 WP_000100034.1 amino acid ABC transporter permease -
  EL071_RS08885 (NCTC8184_01767) - 1727893..1728459 (-) 567 WP_000592389.1 PepSY domain-containing protein -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27063.90 Da        Isoelectric Point: 4.8246

>NTDB_id=1119521 EL071_RS08860 WP_000722052.1 1723857..1724567(-) (vicR) [Streptococcus agalactiae strain NCTC8184]
MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE
LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide


Download         Length: 711 bp        

>NTDB_id=1119521 EL071_RS08860 WP_000722052.1 1723857..1724567(-) (vicR) [Streptococcus agalactiae strain NCTC8184]
ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA
AACGGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA
TGCTCCCTGAACTAGATGGTTTAGAAGTGGCTAAGGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCCGCA
AAAGACAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA
ACTTTTGGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGTGCTCAAAATG
CTTCTTCAGATATTACTATTGGTGAGTTGCAAATTTTACCAGACGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA
TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATAGGACAAGTCATGACACGCGAACATTTATTGGA
AACGGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG
ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB X5K3L1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

88.983

100

0.89
  micA Streptococcus pneumoniae Cp1015

77.778

99.153

0.771
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.983

98.305

0.462
  covR Streptococcus salivarius strain HSISS4

44.635

98.729

0.441
  scnR Streptococcus mutans UA159

38.559

100

0.386

Multiple sequence alignment