Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   ELZ51_RS08480 Genome accession   NZ_LR134094
Coordinates   1681913..1683808 (-) Length   631 a.a.
NCBI ID   WP_115246322.1    Uniprot ID   A0A380JVY4
Organism   Streptococcus dysgalactiae subsp. dysgalactiae strain NCTC4669     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1676913..1688808
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ELZ51_RS08455 (NCTC4669_01791) - 1677662..1678021 (-) 360 WP_003052148.1 S1 RNA-binding domain-containing protein -
  ELZ51_RS08460 (NCTC4669_01792) - 1678021..1679421 (-) 1401 WP_126427053.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ELZ51_RS08465 (NCTC4669_01793) - 1679458..1680099 (-) 642 WP_003052152.1 response regulator transcription factor -
  ELZ51_RS08470 (NCTC4669_01794) - 1680092..1681096 (-) 1005 WP_003052154.1 sensor histidine kinase -
  ELZ51_RS08475 (NCTC4669_01795) liaF 1681093..1681785 (-) 693 WP_115246321.1 cell wall-active antibiotics response protein LiaF -
  ELZ51_RS08480 (NCTC4669_01796) pknB 1681913..1683808 (-) 1896 WP_115246322.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ELZ51_RS08485 (NCTC4669_01797) - 1683805..1684545 (-) 741 WP_115246323.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ELZ51_RS08490 (NCTC4669_01798) rsmB 1684583..1685905 (-) 1323 WP_115246324.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  ELZ51_RS08495 (NCTC4669_01799) fmt 1685895..1686830 (-) 936 WP_003052166.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68842.38 Da        Isoelectric Point: 7.2906

>NTDB_id=1118292 ELZ51_RS08480 WP_115246322.1 1681913..1683808(-) (pknB) [Streptococcus dysgalactiae subsp. dysgalactiae strain NCTC4669]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPVTTPKVAPTPVTSTTERRL
EHTNQMDMLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPNVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPPTGTAKRKGSAITVYLSIGNKGFEMENYKGIDYQEAMASLMETYGVPKLMIKIERIVTNEYTES
TVISQSPSAGDKFNPNGKSKITLSVAVSDTVIMPMVTEYTYADAVNTLTALGIEASRIKAYAPSSSSATGFVQVNSPSSK
AIVSGQTPYYGTTLSLSEKGEISLYLYPEETHSSSSSTSSEASSSSSSTNDGTGTSSNTELSPSESTGQTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=1118292 ELZ51_RS08480 WP_115246322.1 1681913..1683808(-) (pknB) [Streptococcus dysgalactiae subsp. dysgalactiae strain NCTC4669]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTACGTACCAATTATCAGACAGATCAGGTGG
CGGTTGCCCGTTTTCAACGGGAAGCGCGTGCCATGGCTGAATTAAACCATCCTAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATACGTAGATGGCGCTGACTTAAAGAAGTATATTCAAGATCATGCTCC
TCTATCCAATAATGAAGTGGTCAGAATCATGGAAGAGGTGCTTTCTGCCATGACATTAGCTCACCAGAAAGGGATTGTCC
ATAGAGATTTAAAACCTCAAAATATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGACTTTGGGATTGCCGTTGCT
TTTGCGGAAACTAGTTTGACTCAAACTAACTCTATGTTGGGAAGCGTCCATTATCTATCGCCTGAACAGGCTCGCGGCTC
AAAAGCGACTATTCAAAGTGATATTTATGCGATGGGAATTATGCTCTTTGAAATGCTGACAGGACATATCCCTTATGATG
GCGATAGTGCTGTCACCATTGCTTTGCAACATTTCCAAAAGCCTCTTCCATCTATTATCGACGAAAACCACAATGTACCA
CAAGCTTTAGAGAATGTGGTTATCCGAGCAACAGCCAAGAAATTAAGCGATCGTTACGGATCAACCTTTGAAATGAGTCG
TGATCTGATGACGGCTCTCAGTTACAACCGGAGTCGTGAACGGAAAGTTATTTTTGATGATGTGGAAAGCACAAAACCTC
TCCCTAAAGTAACACCGGCACCAGTAACGACGCCAAAAGTAGCTCCAACTCCTGTTACGTCCACAACTGAAAGGCGTTTA
GAGCACACTAATCAGATGGACATGCTCCAGAAACCACAAAAAAAGAAGCGAAATGGTCGTTTTTTGGGGACTTTGTTAAA
AATCCTCTTCTCTCTCTTTATTGTAGGTGTGGCTCTCTTCACTTACTTGGTGCTAACAAAACCTACCTCAGTAAAAGTTC
CTAATGTGACCGGTGTCAGTCTTAAAGTTGCAAAGCAAGAACTGCAAGATTTAGGCTTGAAAGTTGGTAAGGTGAGACAG
ATTGAAAGTGATACTGTTGCGGAAGGGAATGTTGTCCGAACAGATCCACCAACGGGAACAGCCAAGCGCAAGGGTTCAGC
TATCACAGTTTACTTGTCAATTGGCAATAAAGGGTTTGAGATGGAAAACTACAAAGGGATTGATTATCAAGAAGCTATGG
CTAGCTTGATGGAAACCTACGGTGTTCCTAAATTGATGATCAAGATTGAACGAATCGTGACCAATGAATACACGGAAAGT
ACTGTTATTAGCCAATCTCCGAGTGCAGGGGATAAATTTAATCCTAATGGGAAATCTAAAATTACTCTTAGTGTTGCCGT
GAGTGACACAGTCATTATGCCTATGGTAACAGAATATACCTACGCTGATGCAGTAAATACTTTGACAGCATTAGGTATTG
AAGCTTCAAGGATTAAAGCTTATGCTCCAAGCTCAAGTTCAGCAACAGGTTTTGTTCAGGTTAATTCCCCAAGTTCAAAA
GCTATTGTCAGTGGTCAAACTCCTTATTACGGTACCACATTGAGCCTCTCTGAAAAAGGTGAGATAAGCCTTTACCTTTA
CCCAGAAGAAACGCATTCTTCAAGTAGTTCAACTAGTTCTGAGGCAAGTTCTAGCAGTTCCTCAACAAATGATGGAACGG
GAACAAGTAGTAATACTGAATTAAGCCCATCGGAATCAACTGGTCAAACTCCTTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-233)

PASTA domain (PASTA)

(511-587)

PASTA domain (PASTA)

(371-433)

PASTA domain (PASTA)

(440-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380JVY4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.188

92.868

0.605
  stkP/pknB Streptococcus salivarius strain HSISS4

61.849

94.295

0.583
  stkP Streptococcus pneumoniae TIGR4

58.027

81.933

0.475
  stkP Streptococcus pneumoniae D39

57.834

81.933

0.474
  stkP Streptococcus pneumoniae R6

57.834

81.933

0.474
  stkP Streptococcus pneumoniae Rx1

57.64

81.933

0.472

Multiple sequence alignment