Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ELZ42_RS01140 Genome accession   NZ_LR132067
Coordinates   219288..220574 (-) Length   428 a.a.
NCBI ID   WP_002299298.1    Uniprot ID   A0A132P4Z0
Organism   Enterococcus faecium isolate E0139     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 214288..225574
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ELZ42_RS01110 - 214587..215540 (-) 954 WP_002299300.1 glycosyltransferase family 2 protein -
  ELZ42_RS01115 - 215725..216075 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  ELZ42_RS01120 pepA 216275..217354 (+) 1080 WP_002328674.1 glutamyl aminopeptidase -
  ELZ42_RS01125 - 217497..217817 (+) 321 WP_002287837.1 thioredoxin family protein -
  ELZ42_RS01130 - 217839..218303 (+) 465 WP_002287838.1 universal stress protein -
  ELZ42_RS01135 ytpR 218508..219113 (+) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  ELZ42_RS01140 htrA 219288..220574 (-) 1287 WP_002299298.1 S1C family serine protease Regulator
  ELZ42_RS01145 rlmH 221001..221480 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ELZ42_RS01150 - 221606..222559 (+) 954 WP_002328676.1 IS30 family transposase -
  ELZ42_RS01155 - 222576..223886 (+) 1311 WP_025479009.1 NCS2 family permease -
  ELZ42_RS01160 - 224051..225049 (+) 999 WP_002328678.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44827.86 Da        Isoelectric Point: 4.5950

>NTDB_id=1117586 ELZ42_RS01140 WP_002299298.1 219288..220574(-) (htrA) [Enterococcus faecium isolate E0139]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKKYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=1117586 ELZ42_RS01140 WP_002299298.1 219288..220574(-) (htrA) [Enterococcus faecium isolate E0139]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGAATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCGGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGCCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAAAAG
ATGGAAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTCTAGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGTCGA
AACGGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGATCTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATTGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAACGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAAAAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)

Peptidase family M50 (Peptidase_M50)

(10-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A132P4Z0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.962

91.822

0.505
  htrA Streptococcus mutans UA159

60.169

82.71

0.498
  htrA Streptococcus mitis NCTC 12261

52.897

92.757

0.491
  htrA Streptococcus pneumoniae TIGR4

59.347

78.738

0.467
  htrA Streptococcus pneumoniae D39

59.347

78.738

0.467
  htrA Streptococcus pneumoniae Rx1

59.347

78.738

0.467
  htrA Streptococcus pneumoniae R6

59.347

78.738

0.467

Multiple sequence alignment