Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   EW025_RS00330 Genome accession   NZ_LR130238
Coordinates   53093..54004 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain HKU419 isolate HKU419     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 48093..59004
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW025_RS00310 purE 48430..48921 (+) 492 WP_049524746.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  EW025_RS00315 purK 48908..49981 (+) 1074 WP_015055885.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  EW025_RS00320 - 50008..51651 (+) 1644 WP_010921779.1 AIPR family protein -
  EW025_RS00325 purB 51669..52961 (+) 1293 WP_010921780.1 adenylosuccinate lyase -
  EW025_RS00330 comR 53093..54004 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  EW025_RS10500 comS 54088..54183 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  EW025_RS00335 ruvB 54230..55228 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  EW025_RS00340 - 55366..55803 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  EW025_RS00345 - 55826..56227 (+) 402 WP_010921781.1 MORN repeat-containing protein -
  EW025_RS00350 - 56224..57999 (+) 1776 WP_010921782.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=1116592 EW025_RS00330 WP_002986681.1 53093..54004(+) (comR) [Streptococcus pyogenes strain HKU419 isolate HKU419]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=1116592 EW025_RS00330 WP_002986681.1 53093..54004(+) (comR) [Streptococcus pyogenes strain HKU419 isolate HKU419]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment