Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   EW024_RS00340 Genome accession   NZ_LR130237
Coordinates   54350..55261 (+) Length   303 a.a.
NCBI ID   WP_011528143.1    Uniprot ID   A0A660A660
Organism   Streptococcus pyogenes strain SP444 isolate SP444     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 49350..60261
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW024_RS00325 - 50005..51540 (+) 1536 WP_021299446.1 AAA family ATPase -
  EW024_RS00330 - 51533..52417 (+) 885 WP_011528141.1 HNH endonuclease -
  EW024_RS00335 purB 52926..54218 (+) 1293 WP_011528142.1 adenylosuccinate lyase -
  EW024_RS00340 comR 54350..55261 (+) 912 WP_011528143.1 transcriptional regulator Rgg4/ComR Regulator
  EW024_RS09560 comS 55345..55440 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  EW024_RS00345 ruvB 55487..56485 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  EW024_RS00350 - 56623..57060 (+) 438 WP_002987727.1 low molecular weight protein-tyrosine-phosphatase -
  EW024_RS00355 - 57084..57485 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  EW024_RS00360 - 57482..59257 (+) 1776 WP_011528145.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35743.25 Da        Isoelectric Point: 4.4858

>NTDB_id=1116537 EW024_RS00340 WP_011528143.1 54350..55261(+) (comR) [Streptococcus pyogenes strain SP444 isolate SP444]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDVIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=1116537 EW024_RS00340 WP_011528143.1 54350..55261(+) (comR) [Streptococcus pyogenes strain SP444 isolate SP444]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGAATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTGTCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATGTAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(73-296)

Helix-turn-helix (HTH_3)

(12-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A660

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.67

100

0.997
  comR Streptococcus pyogenes MGAS315

58.14

99.34

0.578
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment