Detailed information NTG1116394

Bioinformatically predicted

Overview

• Name: comC/comC1
• Type: Regulator
• Locus tag: EQB46_RS11115
• Genome accession: NZ_LR129843
• Coordinates: 2034727..2034852 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799689.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain 180-2 isolate 180-2
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2029727..2039852

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQB46_RS12165	-	2030067..2031741 (-)	1675	Protein_2059	YhgE/Pip family protein	-
EQB46_RS11090	-	2031848..2032390 (+)	543	WP_001158255.1	TetR/AcrR family transcriptional regulator	-
EQB46_RS11105	comE	2032632..2033384 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQB46_RS11110	comD/comD1	2033381..2034706 (-)	1326	WP_014632435.1	competence system sensor histidine kinase ComD	Regulator
EQB46_RS11115	comC/comC1	2034727..2034852 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQB46_RS11125	rlmH	2035135..2035614 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQB46_RS11130	htrA	2035797..2036978 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EQB46_RS11135	spo0J	2037036..2037794 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4971.00 Da
• Isoelectric Point: 11.0775

>NTDB_id=1116394 EQB46_RS11115 WP_000799689.1 2034727..2034852(-) (comC/comC1) [Streptococcus pneumoniae strain 180-2 isolate 180-2]
MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK

Nucleotide

• Length: 126 bp

>NTDB_id=1116394 EQB46_RS11115 WP_000799689.1 2034727..2034852(-) (comC/comC1) [Streptococcus pneumoniae strain 180-2 isolate 180-2]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GCTGTCAAAATTCTTCCGTGATTTTATTTTACAAAGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-31)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC1	Streptococcus pneumoniae R6	100	100	1
comC/comC1	Streptococcus pneumoniae G54	100	100	1
comC/comC1	Streptococcus pneumoniae D39	100	100	1
comC/comC1	Streptococcus pneumoniae Rx1	100	100	1
comC/comC2	Streptococcus pneumoniae A66	80.488	100	0.805
comC/comC2	Streptococcus pneumoniae TIGR4	80.488	100	0.805
comC	Streptococcus mitis SK321	78.049	100	0.78
comC	Streptococcus mitis NCTC 12261	74.074	65.854	0.488
comC/blpC	Streptococcus mutans UA159	44.444	87.805	0.39