Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   EQB46_RS06035 Genome accession   NZ_LR129843
Coordinates   1122267..1122971 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 180-2 isolate 180-2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1117267..1127971
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB46_RS06005 - 1117448..1118434 (+) 987 WP_000204733.1 L-lactate dehydrogenase -
  EQB46_RS06010 - 1118735..1119478 (-) 744 Protein_1145 potassium channel family protein -
  EQB46_RS06015 - 1119525..1119779 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE family toxin -
  EQB46_RS06020 relB 1119781..1120023 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  EQB46_RS06025 vicX 1120114..1120923 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  EQB46_RS06030 micB 1120925..1122274 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EQB46_RS06035 micA 1122267..1122971 (-) 705 WP_000722076.1 response regulator YycF Regulator
  EQB46_RS06040 mutY 1123026..1124201 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  EQB46_RS06050 - 1124530..1126200 (-) 1671 WP_000845287.1 formate--tetrahydrofolate ligase -
  EQB46_RS06055 coaB 1126430..1127119 (+) 690 WP_000699489.1 phosphopantothenate--cysteine ligase -
  EQB46_RS06060 coaC 1127131..1127682 (+) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=1116348 EQB46_RS06035 WP_000722076.1 1122267..1122971(-) (micA) [Streptococcus pneumoniae strain 180-2 isolate 180-2]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1116348 EQB46_RS06035 WP_000722076.1 1122267..1122971(-) (micA) [Streptococcus pneumoniae strain 180-2 isolate 180-2]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment