Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   A66_RS08035 Genome accession   NZ_LN847353
Coordinates   1546896..1547555 (+) Length   219 a.a.
NCBI ID   WP_000565004.1    Uniprot ID   A0AA95DDC2
Organism   Streptococcus pneumoniae strain A66     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1541896..1552555
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A66_RS07995 (A66_01609) mgaSpn 1542052..1543533 (-) 1482 WP_001205281.1 virulence factor transcriptional regulator MgaSpn -
  A66_RS08000 (A66_01610) - 1543976..1544140 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  A66_RS08005 (A66_01611) amaP 1544224..1544790 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  A66_RS08010 (A66_01612) - 1544802..1544972 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  A66_RS08015 (A66_01613) - 1545011..1545619 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  A66_RS08020 (A66_01614) - 1545650..1545853 (+) 204 WP_000109957.1 CsbD family protein -
  A66_RS08025 - 1545963..1546256 (-) 294 WP_307774273.1 transposase -
  A66_RS08030 (A66_01615) - 1546380..1546826 (-) 447 WP_050214587.1 GNAT family N-acetyltransferase -
  A66_RS08035 (A66_01616) cclA/cilC 1546896..1547555 (+) 660 WP_000565004.1 A24 family peptidase Machinery gene
  A66_RS08040 (A66_01617) - 1547607..1548758 (-) 1152 WP_000481756.1 XRE family transcriptional regulator -
  A66_RS08045 (A66_01618) - 1548773..1549504 (-) 732 WP_000934016.1 hypothetical protein -
  A66_RS11270 - 1549730..1549834 (+) 105 Protein_1577 prepilin peptidase -
  A66_RS08050 (A66_01619) trpA 1549806..1550582 (-) 777 WP_001127044.1 tryptophan synthase subunit alpha -
  A66_RS08055 (A66_01620) trpB 1550575..1551798 (-) 1224 WP_000331292.1 tryptophan synthase subunit beta -
  A66_RS08060 (A66_01621) - 1551776..1552375 (-) 600 WP_000169894.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24842.93 Da        Isoelectric Point: 7.6165

>NTDB_id=1114582 A66_RS08035 WP_000565004.1 1546896..1547555(+) (cclA/cilC) [Streptococcus pneumoniae strain A66]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELSLG
LLFLLYSWGWLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFQLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=1114582 A66_RS08035 WP_000565004.1 1546896..1547555(+) (cclA/cilC) [Streptococcus pneumoniae strain A66]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAAGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGGATGGCTCTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCAGCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-88)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

100

100

1
  cclA/cilC Streptococcus pneumoniae Rx1

94.977

100

0.95
  cclA/cilC Streptococcus pneumoniae D39

94.977

100

0.95
  cclA/cilC Streptococcus pneumoniae R6

94.977

100

0.95
  cclA/cilC Streptococcus mitis SK321

91.781

100

0.918
  cclA/cilC Streptococcus mitis NCTC 12261

87.215

100

0.872

Multiple sequence alignment