Detailed information NTG1111889

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SPYH293_RS08300
• Genome accession: NZ_HG316453
• Coordinates: 1724129..1725352 (+)
• Length: 407 a.a.
• NCBI ID: WP_002994926.1
• Uniprot ID: A0A4U9TAA9
• Organism: Streptococcus pyogenes strain H293
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1719129..1730352

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYH293_RS08285 (SPYH293_01688)	-	1722269..1723043 (-)	775	Protein_1586	IS30 family transposase	-
SPYH293_RS08295 (SPYH293_01690)	rlmH	1723438..1723917 (-)	480	WP_053039081.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPYH293_RS08300 (SPYH293_01691)	htrA	1724129..1725352 (+)	1224	WP_002994926.1	S1C family serine protease	Regulator
SPYH293_RS08305 (SPYH293_01692)	spo0J	1725441..1726217 (+)	777	WP_002994930.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42760.38 Da
• Isoelectric Point: 7.3920

>NTDB_id=1111889 SPYH293_RS08300 WP_002994926.1 1724129..1725352(+) (htrA) [Streptococcus pyogenes strain H293]
MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=1111889 SPYH293_RS08300 WP_002994926.1 1724129..1725352(+) (htrA) [Streptococcus pyogenes strain H293]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTATTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTCAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGACTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGACGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATTAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAGGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

• PDZ domain (PDZ_2) (301-396)

3D structure

• AlphaFold DB: A0A4U9TAA9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.881	99.263	0.614
htrA	Streptococcus gordonii str. Challis substr. CH1	55.224	98.771	0.545
htrA	Streptococcus mitis NCTC 12261	53.071	100	0.531
htrA	Streptococcus pneumoniae Rx1	52.826	100	0.528
htrA	Streptococcus pneumoniae D39	52.826	100	0.528
htrA	Streptococcus pneumoniae R6	52.826	100	0.528
htrA	Streptococcus pneumoniae TIGR4	52.826	100	0.528