Detailed information NTG1111840

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SPYH293_RS00325
• Genome accession: NZ_HG316453
• Coordinates: 53083..53994 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain H293
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48083..58994

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYH293_RS00305 (SPYH293_00064)	purE	48670..49161 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SPYH293_RS00310 (SPYH293_00065)	purK	49148..50221 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SPYH293_RS00315 (SPYH293_00066)	-	50223..51641 (+)	1419	WP_023612101.1	hypothetical protein	-
SPYH293_RS00320 (SPYH293_00067)	purB	51661..52953 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
SPYH293_RS00325 (SPYH293_00068)	comR	53083..53994 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
SPYH293_RS09185	comS	54078..54173 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
SPYH293_RS00330 (SPYH293_00069)	ruvB	54220..55218 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
SPYH293_RS00335 (SPYH293_00070)	-	55356..55793 (+)	438	WP_020904819.1	low molecular weight protein-tyrosine-phosphatase	-
SPYH293_RS00340 (SPYH293_00071)	-	55817..56218 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
SPYH293_RS00345 (SPYH293_00072)	-	56215..57990 (+)	1776	WP_014407199.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1111840 SPYH293_RS00325 WP_002986681.1 53083..53994(+) (comR) [Streptococcus pyogenes strain H293]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1111840 SPYH293_RS00325 WP_002986681.1 53083..53994(+) (comR) [Streptococcus pyogenes strain H293]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAGGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462