Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   HMPREF9319_RS01840 Genome accession   NZ_GL397128
Coordinates   372232..374112 (+) Length   626 a.a.
NCBI ID   WP_003063531.1    Uniprot ID   -
Organism   Streptococcus equinus ATCC 700338     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 367232..379112
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF9319_RS01825 (HMPREF9319_0364) fmt 369210..370145 (+) 936 WP_003063528.1 methionyl-tRNA formyltransferase -
  HMPREF9319_RS01830 (HMPREF9319_0365) rsmB 370135..371457 (+) 1323 WP_003063529.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  HMPREF9319_RS01835 (HMPREF9319_0366) - 371495..372232 (+) 738 WP_003063530.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  HMPREF9319_RS01840 (HMPREF9319_0367) pknB 372232..374112 (+) 1881 WP_003063531.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  HMPREF9319_RS01845 (HMPREF9319_0368) liaF 374207..374902 (+) 696 WP_003063532.1 cell wall-active antibiotics response protein LiaF -
  HMPREF9319_RS01850 (HMPREF9319_0369) - 374899..375924 (+) 1026 WP_003063533.1 sensor histidine kinase -
  HMPREF9319_RS01855 (HMPREF9319_0370) - 375908..376552 (+) 645 WP_003063534.1 response regulator -
  HMPREF9319_RS01860 (HMPREF9319_0371) - 376670..378070 (+) 1401 WP_003063536.1 Cof-type HAD-IIB family hydrolase -
  HMPREF9319_RS01865 (HMPREF9319_0372) - 378070..378426 (+) 357 WP_003063541.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 626 a.a.        Molecular weight: 67866.10 Da        Isoelectric Point: 5.0714

>NTDB_id=1111674 HMPREF9319_RS01840 WP_003063531.1 372232..374112(+) (pknB) [Streptococcus equinus ATCC 700338]
MIQIGKLFAGRYRILKSIGRGGMADVYLAKDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKDGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENKNVP
QALENVVIKATAKRLSDRYASTFEMSRDLMTALSYNRSREPKLVFEDTENTKTLPKVTTSTSVPSTTEQLLKKQKAAKED
KVATENQATKAKTKKKKSRRMFGTLMKIFFAVVIVAIAIFTYLTLTSPSTVSVPDVAGSSLSEAKTTIKSSGLKVGTVHK
VSSDTVESGYVIKTSPTAGSSKKEGSSIDIYVSKGSSGFKIKDYTGQDYQTAVKDLVNNYGVSESQIEIEEVSTSDYDEG
VIISQTPSEGETFKVSGDDKITFKVATESTVTMPNLTGYTYSEAIAALTALGVSSSHITVYQADPNSSTGYVQVSSPSST
ATITAQTPYYGETLSGNVILYLAADEEESSQAPSSSSSEPSESKESSSSSSSTDDSSSSTESSNEQ

Nucleotide


Download         Length: 1881 bp        

>NTDB_id=1111674 HMPREF9319_RS01840 WP_003063531.1 372232..374112(+) (pknB) [Streptococcus equinus ATCC 700338]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATCCTCAAATCTATCGGACGGGGTGGAATGGCAGATGTTTA
TCTGGCAAAAGATCTCATTCTTGATAATGAAGAAGTGGCCATTAAGGTGCTTCGGACGAATTATCAGACTGATCAAATTG
CCGTAGCGCGTTTCCAACGGGAAGCGCGTGCCATGGCAGAACTGAACCATCCAAATATCGTCTCGATTCGTGATATTGGA
GAAGAAGACGGACAGCAATTCTTAGTAATGGAATATGTTGATGGATCGGACTTGAAAAAATACATTCAAGATCATGCTCC
GCTTTCTAATAATGAAGTTGTTAGAATCATGGAAGAAGTCTTATCTGCGATGACTTTGGCGCATCAACAAGGGATTGTTC
ACCGTGATTTAAAACCACAAAATATCTTATTAACCAAAGATGGAACTGTTAAAGTTACTGACTTTGGTATCGCCGTAGCC
TTTGCCGAAACAAGTTTAACGCAAACCAATTCAATGCTAGGTAGTGTGCATTATTTATCGCCTGAACAAGCACGTGGTTC
AAAAGCGACTGTTCAAAGTGATATTTACGCTATGGGGATTATGTTGTTTGAAATGTTAACAGGTCACATCCCATATGATG
GCGATTCAGCTGTTACCATTGCGCTTCAACATTTCCAAAAACCACTTCCTTCTATCATTGATGAGAATAAGAATGTTCCA
CAAGCACTAGAAAATGTTGTTATCAAGGCGACTGCAAAACGTTTAAGTGACCGTTATGCGTCAACTTTTGAAATGAGTCG
TGATTTGATGACGGCACTTTCTTACAACCGTAGCCGTGAACCTAAACTTGTTTTTGAAGATACTGAAAATACAAAGACAC
TTCCAAAGGTAACAACATCAACATCTGTTCCTTCAACGACAGAACAACTCTTGAAGAAACAAAAAGCAGCTAAAGAAGAT
AAAGTAGCAACAGAAAACCAAGCGACTAAAGCTAAAACAAAGAAGAAAAAATCACGTCGTATGTTCGGCACGTTAATGAA
AATCTTTTTTGCAGTTGTGATTGTAGCTATTGCTATCTTTACTTACTTGACGTTGACCTCACCATCAACCGTGAGTGTTC
CAGATGTTGCTGGCTCTAGTTTATCAGAAGCAAAAACAACGATAAAATCATCAGGTCTTAAAGTTGGAACCGTTCATAAA
GTATCAAGTGATACCGTTGAGAGTGGTTACGTTATTAAGACAAGTCCAACTGCTGGTTCATCGAAAAAAGAAGGGTCATC
AATTGATATTTACGTATCAAAAGGCTCATCAGGATTCAAGATAAAAGACTATACAGGTCAAGATTATCAAACAGCCGTTA
AAGATTTGGTTAATAATTACGGTGTTTCAGAGTCGCAAATTGAGATTGAAGAAGTCTCAACGTCAGACTATGACGAAGGT
GTTATCATCAGTCAAACGCCTAGTGAAGGTGAAACCTTTAAGGTAAGTGGTGATGATAAGATTACCTTTAAAGTAGCCAC
AGAAAGTACAGTGACAATGCCGAATTTGACAGGCTATACTTATTCAGAAGCTATTGCTGCCTTAACAGCTCTAGGCGTGT
CAAGTTCACATATTACGGTTTATCAAGCCGACCCAAATTCTTCTACGGGTTATGTGCAAGTAAGCTCACCATCTTCAACA
GCAACTATCACTGCTCAAACACCTTACTATGGTGAAACGTTAAGTGGTAACGTGATACTTTACCTAGCAGCTGATGAAGA
AGAAAGCTCACAGGCGCCATCGTCATCAAGTTCAGAACCCTCTGAATCAAAAGAATCAAGTTCATCAAGTAGCAGTACGG
ATGATAGTAGCTCATCAACAGAATCAAGTAATGAACAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(371-434)

PASTA domain (PASTA)

(440-506)

PASTA domain (PASTA)

(511-575)

Protein kinase domain (Pkinase)

(12-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

68.313

93.77

0.641
  stkP/pknB Streptococcus salivarius strain HSISS4

64.646

94.888

0.613
  stkP Streptococcus pneumoniae TIGR4

54.452

93.291

0.508
  stkP Streptococcus pneumoniae D39

54.281

93.291

0.506
  stkP Streptococcus pneumoniae R6

54.281

93.291

0.506
  stkP Streptococcus pneumoniae Rx1

54.11

93.291

0.505

Multiple sequence alignment