Detailed information NTG1111474

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACN076_RS09795
• Genome accession: NZ_CP184836
• Coordinates: 1972142..1972879 (-)
• Length: 245 a.a.
• NCBI ID: WP_420789911.1
• Uniprot ID: -
• Organism: Streptococcus sp. K0074
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1967142..1977879

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACN076_RS09765 (ACN076_09765)	-	1967240..1967593 (-)	354	Protein_1877	CPBP family intramembrane glutamate endopeptidase	-
ACN076_RS09770 (ACN076_09770)	blpZ	1967623..1967871 (-)	249	WP_420789906.1	immunity protein BlpZ	-
ACN076_RS09775 (ACN076_09775)	-	1967912..1968601 (-)	690	WP_420789907.1	CPBP family intramembrane glutamic endopeptidase	-
ACN076_RS09780 (ACN076_09780)	-	1968665..1969048 (-)	384	WP_420789908.1	immunity protein	-
ACN076_RS09785 (ACN076_09785)	-	1969131..1969535 (-)	405	WP_420789909.1	immunity protein	-
ACN076_RS09790 (ACN076_09790)	-	1970788..1972128 (-)	1341	WP_420789910.1	sensor histidine kinase	-
ACN076_RS09795 (ACN076_09795)	comE/blpR	1972142..1972879 (-)	738	WP_420789911.1	response regulator transcription factor	Regulator
ACN076_RS09800 (ACN076_09800)	-	1973175..1973504 (+)	330	WP_420789912.1	helicase BlpT	-
ACN076_RS09805 (ACN076_09805)	-	1973566..1974615 (-)	1050	WP_420789913.1	ABC transporter permease	-
ACN076_RS09810 (ACN076_09810)	pptA	1974612..1975343 (-)	732	WP_420789914.1	ABC transporter ATP-binding protein	Regulator
ACN076_RS09815 (ACN076_09815)	-	1975411..1975821 (+)	411	WP_001278320.1	HIT family protein	-
ACN076_RS09820 (ACN076_09820)	-	1975831..1976118 (+)	288	WP_000777754.1	hypothetical protein	-
ACN076_RS09825 (ACN076_09825)	dnaJ	1976399..1977535 (-)	1137	WP_420789915.1	molecular chaperone DnaJ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28822.99 Da
• Isoelectric Point: 6.5017

>NTDB_id=1111474 ACN076_RS09795 WP_420789911.1 1972142..1972879(-) (comE/blpR) [Streptococcus sp. K0074]
MRIFVLEDDFSQQTRIEATIEKLLKEHHITPSSFEVFGKPEQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRNRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCMIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1111474 ACN076_RS09795 WP_420789911.1 1972142..1972879(-) (comE/blpR) [Streptococcus sp. K0074]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAGCGACGATTGAGAAACTCTTGAAAGAACA
TCACATCACTCCCAGCTCTTTTGAAGTTTTTGGCAAACCAGAGCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGAATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCGGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGACA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTCTACTAT
CTCGAAACATCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGACTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCTCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTGGTTCGTTTGGATA
AGAAAGAAAAACTTCTTTACTTTCCCAATGGTGGAAGCTGTATGATAGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT
ATCAATAACTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.733	99.184	0.543
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363