Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ACN076_RS04650 Genome accession   NZ_CP184836
Coordinates   962600..963337 (+) Length   245 a.a.
NCBI ID   WP_000782684.1    Uniprot ID   I0SX41
Organism   Streptococcus sp. K0074     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 957600..968337
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACN076_RS04630 (ACN076_04630) - 957682..958785 (+) 1104 WP_153192528.1 glycosyltransferase -
  ACN076_RS04635 (ACN076_04635) - 958787..959773 (+) 987 WP_153192526.1 glycosyltransferase family 2 protein -
  ACN076_RS04640 (ACN076_04640) - 959789..961258 (+) 1470 WP_420790218.1 O-antigen polysaccharide polymerase Wzy family protein -
  ACN076_RS04645 (ACN076_04645) - 961251..962285 (+) 1035 WP_420790219.1 prephenate dehydratase -
  ACN076_RS04650 (ACN076_04650) mecA 962600..963337 (+) 738 WP_000782684.1 adaptor protein MecA Regulator
  ACN076_RS04655 (ACN076_04655) - 963489..964775 (+) 1287 WP_023946376.1 homoserine dehydrogenase -
  ACN076_RS04660 (ACN076_04660) thrB 964777..965646 (+) 870 WP_024057159.1 homoserine kinase -
  ACN076_RS04665 (ACN076_04665) msrB 965745..966683 (+) 939 WP_420790220.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28436.26 Da        Isoelectric Point: 4.0199

>NTDB_id=1111451 ACN076_RS04650 WP_000782684.1 962600..963337(+) (mecA) [Streptococcus sp. K0074]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEVESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMNHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1111451 ACN076_RS04650 WP_000782684.1 962600..963337(+) (mecA) [Streptococcus sp. K0074]
ATGAAAATGAAACAAATCAGTGATACAACTTTAAAAATCACGATGTCTTTAGAAGATTTGATGGATCGAGGCATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TCCTAGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTCGATGTCTTTGTAACCAAATCAAAGATT
GACCAAAATCTAGATTTTGAAGATTTATCGGATTTGCCAGACATGGAAGAATTGGCTCAAATGTCGCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGTATCGCGGACAAAACTAAGGATGATATCGAAGCCATTCAATCTCTAGAGCAAGTCGAAGCCA
AGGAAGAAGAGCAGGAGCAGGCTGAACAAGAAGTTGAGAGCAAGAAAGAGCCCTACATCTATTACATCCTTTCTTTCGCA
AAATTAGCTGATTTGGTGGCTTTTGCCAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCGTGGCTTTTGGCTCGTATGCGCGAGT
TTGCAGACGATAGTGACATCAGTCGTTCAGTCTTGCAAGAGTATGGCCAAGTCTTGATGAATCACGATGCTGTGCTCAAT
CTGCAAAAAATCGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SX41

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

98.776

100

0.988
  mecA Streptococcus pneumoniae D39

98.776

100

0.988
  mecA Streptococcus pneumoniae R6

98.776

100

0.988
  mecA Streptococcus pneumoniae TIGR4

98.367

100

0.984
  mecA Streptococcus mutans UA159

48.163

100

0.482
  mecA Streptococcus thermophilus LMD-9

46.988

100

0.478
  mecA Streptococcus thermophilus LMG 18311

46.586

100

0.473

Multiple sequence alignment