Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ACMDB6_RS09650 Genome accession   NZ_CP178852
Coordinates   1931411..1932550 (-) Length   379 a.a.
NCBI ID   WP_014325193.1    Uniprot ID   A0A5M8XCI1
Organism   Leuconostoc mesenteroides strain F17     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1926411..1937550
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACMDB6_RS09630 (ACMDB6_09645) - 1926796..1927461 (+) 666 WP_010285559.1 NAD(P)H-hydrate epimerase -
  ACMDB6_RS09635 (ACMDB6_09650) - 1927546..1927998 (-) 453 WP_011680485.1 Rrf2 family transcriptional regulator -
  ACMDB6_RS09640 (ACMDB6_09655) - 1928052..1930217 (-) 2166 WP_370928706.1 YhgE/Pip family protein -
  ACMDB6_RS09645 (ACMDB6_09660) rlmH 1930311..1930790 (-) 480 WP_011680487.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACMDB6_RS09650 (ACMDB6_09665) htrA 1931411..1932550 (-) 1140 WP_014325193.1 S1C family serine protease Regulator
  ACMDB6_RS09655 (ACMDB6_09670) yycI 1932611..1933414 (-) 804 WP_010289058.1 two-component system regulatory protein YycI -
  ACMDB6_RS09660 (ACMDB6_09675) - 1933471..1934763 (-) 1293 WP_413981451.1 hypothetical protein -
  ACMDB6_RS09665 (ACMDB6_09680) walK 1934753..1936618 (-) 1866 WP_413981452.1 cell wall metabolism sensor histidine kinase WalK -
  ACMDB6_RS09670 (ACMDB6_09685) yycF 1936686..1937393 (-) 708 WP_261650092.1 response regulator YycF -

Sequence

Protein


Download         Length: 379 a.a.        Molecular weight: 39210.48 Da        Isoelectric Point: 9.7777

>NTDB_id=1091947 ACMDB6_RS09650 WP_014325193.1 1931411..1932550(-) (htrA) [Leuconostoc mesenteroides strain F17]
MVQSALTKTLLTGVIAGVVGGGAILYGQQGVQLLQNQNQKVSTTATSTKTIAKNATATSAYNKVSDAVVSVLNFTKSSQG
SYQESSEGSGVIYKKTDGSAFIVTNNHVITGAAKIQVMLHSGKKVTATLVGKDAMTDLAVLKIDGTDVTTTAQFGDSSKI
TVGENVLAIGSPLGSEYASSVTQGIISAKKRLVEATSENGQNYGGSTVIQTDAAINPGNSGGPLINFAGQVIGINSMKLS
TSSSGTSVEGMGFAIPSDQVVDIVNKLVKDGKVTRPAIGISLINLSEVTASEQKSTLKIPDSVTGGVVVMSLTNNGPADK
AGLKKYDVIVGINGKKVSSQADLREELYKHSLGDTITLTYYHQDTKQTVKVKLTQKLAS

Nucleotide


Download         Length: 1140 bp        

>NTDB_id=1091947 ACMDB6_RS09650 WP_014325193.1 1931411..1932550(-) (htrA) [Leuconostoc mesenteroides strain F17]
ATGGTACAATCAGCATTAACAAAAACGTTGTTAACTGGCGTCATTGCTGGTGTTGTTGGTGGAGGAGCAATTTTGTATGG
GCAGCAGGGTGTACAATTGTTACAAAATCAAAATCAAAAAGTGAGTACGACAGCAACAAGTACAAAAACGATTGCCAAGA
ATGCAACTGCTACATCAGCTTATAATAAGGTATCAGATGCAGTTGTATCTGTATTGAACTTTACTAAATCCAGTCAAGGT
AGTTATCAAGAATCGTCAGAAGGTTCTGGCGTGATCTATAAAAAAACGGATGGATCGGCATTTATTGTAACGAATAATCA
CGTAATCACTGGAGCGGCTAAAATTCAAGTTATGCTGCACAGTGGGAAGAAAGTGACCGCTACATTAGTCGGCAAAGATG
CGATGACTGACTTAGCTGTTCTGAAAATCGACGGCACAGACGTTACAACAACTGCACAATTTGGCGATTCAAGTAAAATA
ACTGTTGGTGAAAACGTCTTGGCAATTGGTTCGCCGCTGGGATCTGAGTATGCTTCGTCAGTGACGCAAGGCATCATTTC
GGCCAAGAAAAGGTTAGTTGAGGCAACATCTGAAAATGGTCAAAATTATGGTGGATCCACGGTTATTCAGACGGATGCTG
CTATTAATCCTGGTAACTCAGGTGGACCATTAATCAACTTTGCAGGACAAGTTATTGGTATTAACTCAATGAAGTTATCA
ACATCTTCTTCTGGAACGAGCGTTGAGGGGATGGGTTTTGCAATTCCTTCTGATCAAGTCGTTGACATTGTTAACAAATT
AGTCAAAGATGGTAAAGTCACACGACCAGCAATTGGCATTAGTTTGATTAATTTGTCAGAAGTAACAGCTTCTGAGCAAA
AATCAACATTGAAAATTCCAGATAGCGTTACTGGTGGTGTTGTTGTAATGAGTTTGACTAACAATGGCCCAGCAGATAAA
GCTGGATTGAAGAAGTACGACGTTATTGTTGGCATTAATGGTAAAAAGGTCAGCTCACAGGCTGATCTGCGAGAAGAACT
CTACAAGCATTCGCTTGGGGACACAATAACATTGACTTATTATCATCAGGATACTAAGCAAACCGTCAAGGTTAAATTAA
CACAGAAATTAGCAAGCTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(276-373)

Peptidase family M50 (Peptidase_M50)

(221-375)

Trypsin-like peptidase domain (Trypsin_2)

(88-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5M8XCI1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

52.394

93.668

0.491
  htrA Streptococcus gordonii str. Challis substr. CH1

48.549

100

0.485
  htrA Streptococcus pneumoniae D39

52.924

90.237

0.478
  htrA Streptococcus pneumoniae TIGR4

52.924

90.237

0.478
  htrA Streptococcus pneumoniae R6

52.924

90.237

0.478
  htrA Streptococcus pneumoniae Rx1

52.924

90.237

0.478
  htrA Streptococcus mutans UA159

52.647

89.71

0.472

Multiple sequence alignment