Detailed information NTG1085956

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: ACJWMC_RS08000
• Genome accession: NZ_CP177181
• Coordinates: 1733517..1735757 (-)
• Length: 746 a.a.
• NCBI ID: WP_002891564.1
• Uniprot ID: J7SHS1
• Organism: Streptococcus salivarius strain MRD1919
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1728517..1740757

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACJWMC_RS07980	-	1729385..1730245 (-)	861	WP_002891560.1	methionyl aminopeptidase	-
ACJWMC_RS07985	spxR	1730285..1731565 (-)	1281	WP_037598368.1	CBS-HotDog domain-containing transcription factor SpxR	-
ACJWMC_RS07990	-	1731558..1732103 (-)	546	WP_037598369.1	GNAT family N-acetyltransferase	-
ACJWMC_RS07995	-	1732169..1733431 (-)	1263	WP_037598371.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
ACJWMC_RS08000	comEC/celB	1733517..1735757 (-)	2241	WP_002891564.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ACJWMC_RS08005	comEA	1735747..1736442 (-)	696	WP_002891565.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACJWMC_RS08010	-	1736551..1737306 (-)	756	WP_002891566.1	lysophospholipid acyltransferase family protein	-
ACJWMC_RS08015	-	1737436..1738371 (+)	936	WP_037598582.1	polysaccharide deacetylase family protein	-
ACJWMC_RS08020	-	1738421..1739173 (+)	753	WP_002891568.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
ACJWMC_RS08025	-	1739190..1739459 (+)	270	WP_002891570.1	GIY-YIG nuclease family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84350.04 Da
• Isoelectric Point: 9.6833

>NTDB_id=1085956 ACJWMC_RS08000 WP_002891564.1 1733517..1735757(-) (comEC/celB) [Streptococcus salivarius strain MRD1919]
MWLKKAPINLFSLSLLIAALYFTIFVTNVYAIGAFVFLMVCFLKHHWKNKAALKLVGLVGSFFLVYFLFLHHRASVQDKQ
APAEINQVTLVADTLSVNGEQLSAIGKAKGQTYQIFYRLKSEKEQHFFKTTSQTLVLKGKINLSQATAQRNFQGFNYQSY
LASQGIYRIAQIERLDQVVPQKSLSPLAFFHQLRRRALVHIQTHFPSPMRHYMTGLLFGYLDKEFDEQSQLYTSLGIIHL
FALSGMQVGFFLGWFRYGLLRLGLPKDYLFIVLLPFSLCYGLMTGWTASVLRSLVQSLLAEFGIKKLDNMGITLLLLFLL
LPHFLLTVGGVLSCSYAFLLCLFDFEDLSSLKKSIYTSLVLSLGILPFLTYYYGTFQPVSLILTAIFSIVFDSFLLPVLT
VFFALSGLVIFSQINPLFEWMESFLTWIQSWIGQPLILGKPSLFQFGLMIAVLVMLFDFWKKPQFRICLLMIFGLLMVWV
KHPLTNEVTVVDVGQGDSIFLRSMKGDTILIDVGGKVTFGTKEKWQESSQTSNAEKTLIPYLKARGVSQIDYLVLTHTDT
DHIGDLEEVAKCFKIKEICVSQGALTKPSFVKRLRTIKCPVHTLKAGDKLPMMGSNLQVLYPNKVGDGGNNDSIVLYGKL
LGSSFLFTGDLEKEGEEELMASYPTLRASVLKAGHHGSKGSSSEAFLDQLHPSLALVSAGENNRYKHPNDETIERFKQRH
IKILRTDKDGAIRFKGWFKWSSETVR

Nucleotide

• Length: 2241 bp

>NTDB_id=1085956 ACJWMC_RS08000 WP_002891564.1 1733517..1735757(-) (comEC/celB) [Streptococcus salivarius strain MRD1919]
ATGTGGCTTAAAAAAGCTCCAATCAATCTTTTTTCCTTGTCTCTTTTAATAGCTGCCCTTTATTTTACGATTTTTGTCAC
TAATGTTTACGCTATTGGTGCTTTTGTCTTTCTTATGGTCTGTTTTTTGAAGCATCATTGGAAGAATAAGGCAGCCCTAA
AGTTGGTGGGACTTGTAGGTAGTTTCTTTTTGGTCTACTTTTTATTCTTGCACCACAGAGCTAGCGTACAAGATAAACAA
GCCCCTGCTGAAATCAATCAGGTGACTCTGGTTGCTGATACGCTATCGGTTAATGGTGAGCAATTATCAGCTATCGGTAA
GGCAAAGGGACAAACCTATCAGATCTTTTACCGACTCAAATCTGAGAAGGAGCAGCATTTTTTCAAGACTACTAGCCAAA
CGTTGGTATTGAAGGGAAAAATAAACTTATCTCAAGCAACTGCTCAGCGTAATTTTCAAGGGTTTAATTATCAGTCTTAT
CTAGCCAGTCAAGGTATTTATCGAATTGCTCAGATTGAGCGCTTGGACCAAGTGGTACCTCAAAAATCTCTATCTCCCCT
AGCTTTTTTCCATCAACTGAGGAGGAGGGCTTTGGTTCATATCCAGACGCACTTTCCTAGTCCTATGAGACACTATATGA
CAGGCCTGCTCTTTGGGTATTTGGATAAGGAGTTTGATGAGCAGAGCCAGCTTTACACAAGTTTAGGTATTATTCATCTA
TTCGCACTTTCGGGGATGCAAGTAGGCTTTTTTCTGGGATGGTTTCGCTACGGTCTCCTACGCTTAGGTCTTCCTAAAGA
TTATCTATTTATCGTCTTGCTGCCTTTTTCCTTATGTTATGGCTTAATGACAGGATGGACAGCTTCAGTCCTACGTTCCT
TGGTTCAAAGTTTGTTGGCGGAGTTTGGTATTAAAAAACTGGACAATATGGGAATAACCTTGCTTCTATTGTTTCTCTTA
TTACCTCATTTTCTCTTAACAGTGGGAGGTGTATTAAGTTGTTCCTATGCCTTCTTGTTGTGTTTGTTTGATTTTGAGGA
CTTGTCATCTTTAAAGAAATCAATCTATACGAGCTTGGTATTGAGTCTTGGGATTTTACCCTTTTTAACCTACTATTATG
GGACTTTTCAACCAGTTAGTTTGATTCTCACTGCAATCTTTTCAATTGTATTTGATAGCTTTCTCTTGCCTGTATTGACA
GTATTCTTTGCCCTCTCAGGATTGGTAATCTTCTCTCAAATCAACCCACTTTTTGAATGGATGGAGTCCTTTTTGACTTG
GATACAATCCTGGATAGGTCAACCTTTGATTTTAGGGAAACCTAGTTTGTTTCAGTTTGGCTTGATGATAGCAGTATTGG
TTATGCTCTTTGATTTTTGGAAAAAGCCTCAGTTTAGGATTTGCCTTTTGATGATTTTTGGACTTTTGATGGTCTGGGTC
AAACATCCTTTAACCAATGAGGTGACTGTGGTTGACGTTGGTCAGGGAGATAGTATTTTTCTGAGGAGTATGAAAGGCGA
TACCATCCTAATTGATGTGGGTGGCAAGGTGACGTTTGGAACTAAGGAAAAATGGCAAGAGTCTAGCCAGACGAGCAATG
CGGAGAAAACCTTGATTCCCTATCTAAAGGCTAGAGGAGTGTCTCAAATTGATTATCTGGTCCTGACGCATACGGACACA
GACCATATTGGTGATTTGGAAGAAGTGGCCAAGTGTTTTAAGATTAAGGAAATCTGTGTCAGTCAGGGGGCTTTGACTAA
GCCTAGCTTTGTTAAAAGACTTCGGACTATAAAATGCCCAGTTCACACTCTAAAGGCTGGCGACAAATTACCCATGATGG
GAAGCAATCTACAGGTTCTTTATCCAAATAAAGTTGGTGATGGCGGTAACAATGATTCGATAGTTCTTTACGGAAAGCTA
TTAGGAAGCAGTTTTCTGTTTACCGGTGATTTGGAAAAAGAAGGAGAGGAGGAACTGATGGCCAGCTATCCAACTTTAAG
GGCAAGCGTCCTCAAAGCTGGACACCACGGTTCAAAAGGTTCTTCGTCTGAAGCTTTTTTGGACCAGCTGCACCCCTCCC
TTGCACTTGTTTCAGCTGGTGAGAACAATCGTTATAAACATCCAAATGATGAAACAATAGAACGTTTTAAGCAACGCCAC
ATTAAAATTTTACGAACAGATAAAGACGGAGCCATCCGTTTTAAGGGCTGGTTTAAATGGTCAAGTGAAACAGTCCGATA
A

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-462)

• Domain of unknown function (DUF4131) (DUF4131) (30-171)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-694)

3D structure

• AlphaFold DB: J7SHS1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	48.133	100	0.484
comEC/celB	Streptococcus mitis NCTC 12261	48.064	100	0.483
comEC/celB	Streptococcus pneumoniae Rx1	46.667	100	0.469
comEC/celB	Streptococcus pneumoniae D39	46.667	100	0.469
comEC/celB	Streptococcus pneumoniae R6	46.667	100	0.469
comEC/celB	Streptococcus pneumoniae TIGR4	46.328	100	0.465
comEC	Lactococcus lactis subsp. cremoris KW2	43.902	98.928	0.434