Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP/pknB   Type   Regulator
Locus tag   ACJWMC_RS07370 Genome accession   NZ_CP177181
Coordinates   1599629..1601503 (-) Length   624 a.a.
NCBI ID   WP_002891421.1    Uniprot ID   J7TTX2
Organism   Streptococcus salivarius strain MRD1919     
Function   activate comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1594629..1606503
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJWMC_RS07335 rimM 1595011..1595529 (-) 519 WP_002891416.1 ribosome maturation factor RimM -
  ACJWMC_RS07350 - 1596224..1596868 (-) 645 WP_002891417.1 response regulator transcription factor -
  ACJWMC_RS07355 - 1596858..1597868 (-) 1011 WP_002891418.1 sensor histidine kinase -
  ACJWMC_RS07360 liaF 1597865..1598563 (-) 699 WP_002891419.1 cell wall-active antibiotics response protein LiaF -
  ACJWMC_RS07365 - 1598726..1599484 (-) 759 WP_037598279.1 potassium channel family protein -
  ACJWMC_RS07370 stkP/pknB 1599629..1601503 (-) 1875 WP_002891421.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ACJWMC_RS07375 - 1601503..1602240 (-) 738 WP_037598574.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ACJWMC_RS07380 rsmB 1602284..1603606 (-) 1323 WP_037598576.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  ACJWMC_RS07385 fmt 1603596..1604531 (-) 936 WP_002891425.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 624 a.a.        Molecular weight: 67966.75 Da        Isoelectric Point: 6.7045

>NTDB_id=1085949 ACJWMC_RS07370 WP_002891421.1 1599629..1601503(-) (stkP/pknB) [Streptococcus salivarius strain MRD1919]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNEKVAIKVLRTNYQTDQVAVARFQREARAMAELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHRRDAKVVFDDMTDTKTLPKVDPVPSASLEKKAVAAEPSEPTPA
PSKQPRKKTTPAKKKKKKNFFSTLLKVFLGLVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKIEGAGFKVGEVKEV
EDDSVDTGKVIKTDPTAGTTRKEGSSIDVYVSSGSKGFALKDYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDSAEEGE
ILSQSPGKNKSFNPKDSKAKIKFRVATPKIVTMPDVTGLTVSTAVQTLNRKNISSSSIEYHDYNTGAKLDKDKIPSSTEV
LYQDPQAGTSVDGTVILYVSVATASSNLQSSSSSTTHSSSTSSSTDSTTSSTETSTEATHTELQ

Nucleotide


Download         Length: 1875 bp        

>NTDB_id=1085949 ACJWMC_RS07370 WP_002891421.1 1599629..1601503(-) (stkP/pknB) [Streptococcus salivarius strain MRD1919]
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAATGACCTGATTCTGGATAATGAAAAAGTGGCTATTAAGGTACTTCGTACCAATTACCAAACTGATCAGGTGG
CTGTGGCCCGTTTCCAACGTGAAGCGCGTGCCATGGCAGAACTCAGTCATCCTAATATCGTTGCTATCCGAGATATTGGC
GAAGAAGACGGCCAGCAGTTCTTGGTGATGGAGTATGTGGACGGTTCGGACTTGAAGAAATACATTCAAGACCATGCGCC
ACTTTCTAACCAAGATGTTGTGCGTATCATGGGGGAGGTCCTTTCCGCCATGACTCTTGCCCATCAAAAGGGCATTATCC
ACCGTGACCTTAAGCCGCAAAACGTTCTTTTAACTAAGGACGGTACAGCCAAGGTCACAGACTTCGGAATTGCGGTTGCC
TTTGCAGAGACTAGTCTAACTCAAACGAATTCTATGTTGGGTTCTGTCCACTACCTGTCACCAGAGCAGGCTCGTGGATC
TAAAGCGACTATCCAAAGTGACATCTATGCTATGGGTATTATGCTTTTTGAAATGTTGACAGGTCATATTCCTTATGATG
GCGATAGTGCAGTAACCATTGCACTCCAACATTTCCAAAAACCACTACCATCGATTTTGGCAGAGAACCGTAACGTTCCC
CAAGCTTTGGAAAATGTGGTTATTCGAGCAACAGCCAAAAAACTAGAAAATCGTTACAATAGTACTTTGGAAATGAGCCG
TGACTTGGTAACGAGTTTGCATCCTAGTCATCGACGCGATGCTAAGGTAGTCTTTGATGATATGACGGATACCAAGACCT
TGCCGAAGGTTGATCCAGTTCCATCAGCAAGTCTTGAGAAAAAAGCCGTTGCTGCTGAACCATCAGAGCCTACACCTGCT
CCAAGTAAACAACCAAGGAAAAAAACGACACCAGCTAAGAAGAAAAAGAAGAAGAACTTCTTCTCAACCTTACTCAAGGT
TTTCCTAGGACTTGTCTTTATTGGTATTATCATCTTTGCTTATTTAGTCTTTACCAATCCTGATAATGTCCAAGTACCTA
ATGTGGTCGGTCAGGAGTTGTCCACAGCTCAGACTAAAATTGAGGGTGCTGGATTTAAGGTAGGAGAAGTCAAAGAAGTG
GAAGATGACTCTGTCGATACGGGTAAGGTCATCAAGACCGATCCTACAGCTGGAACCACACGAAAAGAAGGATCAAGCAT
TGATGTCTATGTTTCTTCTGGTAGTAAAGGTTTCGCTTTGAAAGACTACAAGGGTAAAAACTATAAGGATGCCATTGAGG
ATTTAACTTCGAATTATGGTGTTTCTGAGGACCAAATTGATATTCAGCATGTCGAAGACGACAGTGCTGAAGAGGGAGAA
ATCCTATCTCAAAGTCCAGGGAAAAACAAGTCTTTCAATCCTAAGGATAGTAAGGCTAAGATTAAGTTCCGTGTGGCAAC
GCCTAAGATAGTTACCATGCCTGATGTGACTGGTTTGACGGTTTCAACAGCAGTTCAAACCTTGAATCGTAAGAATATCT
CAAGTAGTAGCATCGAGTACCACGACTATAATACTGGTGCTAAGTTAGATAAGGATAAGATTCCTAGCAGTACGGAGGTC
CTTTATCAAGATCCACAAGCTGGTACAAGTGTTGATGGTACAGTGATTCTCTATGTTTCGGTTGCAACAGCAAGTTCAAA
CCTTCAGTCAAGCTCAAGTAGTACGACACATTCGTCATCAACGAGCTCAAGTACTGACAGTACAACTTCAAGCACTGAAA
CCTCGACAGAGGCTACTCACACAGAACTACAATAG

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(441-505)

PASTA domain (PASTA)

(511-580)

PASTA domain (PASTA)

(370-432)

Protein kinase domain (Pkinase)

(12-235)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TTX2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP/pknB Streptococcus salivarius strain HSISS4

99.199

100

0.992
  pknB Streptococcus mutans UA159

67.159

86.859

0.583
  stkP Streptococcus pneumoniae TIGR4

59.109

79.167

0.468
  stkP Streptococcus pneumoniae Rx1

58.704

79.167

0.465
  stkP Streptococcus pneumoniae D39

58.932

78.045

0.46
  stkP Streptococcus pneumoniae R6

58.932

78.045

0.46

Multiple sequence alignment