Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA   Type   Machinery gene
Locus tag   ACJVC4_RS07985 Genome accession   NZ_CP177179
Coordinates   1737567..1738262 (-) Length   231 a.a.
NCBI ID   WP_002891565.1    Uniprot ID   J7TU97
Organism   Streptococcus salivarius strain MRD-NRLLH     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1719597..1740191 1737567..1738262 within 0


Gene organization within MGE regions


Location: 1719597..1740191
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJVC4_RS07915 ligA 1719597..1721555 (-) 1959 WP_037598365.1 NAD-dependent DNA ligase LigA -
  ACJVC4_RS07920 - 1721719..1723060 (-) 1342 Protein_1520 IS3 family transposase -
  ACJVC4_RS07925 - 1723145..1723822 (+) 678 WP_002890056.1 helix-turn-helix domain-containing protein -
  ACJVC4_RS07930 - 1723819..1724784 (+) 966 WP_002890057.1 IS3 family transposase -
  ACJVC4_RS07935 tnpA 1725000..1725473 (-) 474 WP_002891552.1 IS200/IS605 family transposase -
  ACJVC4_RS07940 - 1726189..1727361 (+) 1173 WP_002891554.1 SIR2 family protein -
  ACJVC4_RS07945 - 1727354..1728979 (+) 1626 WP_002891555.1 ATP-binding protein -
  ACJVC4_RS07950 - 1729644..1730153 (-) 510 WP_002891556.1 QueT transporter family protein -
  ACJVC4_RS07955 - 1730244..1731203 (-) 960 WP_002891558.1 YihY/virulence factor BrkB family protein -
  ACJVC4_RS07960 - 1731205..1732065 (-) 861 WP_002891560.1 methionyl aminopeptidase -
  ACJVC4_RS07965 spxR 1732105..1733385 (-) 1281 WP_037598368.1 CBS-HotDog domain-containing transcription factor SpxR -
  ACJVC4_RS07970 - 1733378..1733923 (-) 546 WP_037598369.1 GNAT family N-acetyltransferase -
  ACJVC4_RS07975 - 1733989..1735251 (-) 1263 WP_037598371.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
  ACJVC4_RS07980 comEC/celB 1735337..1737577 (-) 2241 WP_002891564.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  ACJVC4_RS07985 comEA 1737567..1738262 (-) 696 WP_002891565.1 helix-hairpin-helix domain-containing protein Machinery gene
  ACJVC4_RS07990 - 1738371..1739126 (-) 756 WP_002891566.1 lysophospholipid acyltransferase family protein -
  ACJVC4_RS07995 - 1739256..1740191 (+) 936 WP_037598582.1 polysaccharide deacetylase family protein -

Sequence

Protein


Download         Length: 231 a.a.        Molecular weight: 24517.50 Da        Isoelectric Point: 4.7452

>NTDB_id=1085818 ACJVC4_RS07985 WP_002891565.1 1737567..1738262(-) (comEA) [Streptococcus salivarius strain MRD-NRLLH]
MKEKILAYVKDNRLFVSVIAVLMVIFCFFLWMTCGAGNSMEAETSYTDVTTLSTSSSKQGSQSLSEASSQSKTEESEKDK
SKVTVDVKGAVVKPGVYTLKAGTRVTDAIKAAGGMTEDADAKSINLAASLSDEEVIYVATKDENLSVLGQSGTSQVSDKG
GQTNAKDGKINLNTATAEELQTISGIGAKRAEDIIAYRESHGGFQSVDDLKNVSGIGDKTLDKIRESIYVA

Nucleotide


Download         Length: 696 bp        

>NTDB_id=1085818 ACJVC4_RS07985 WP_002891565.1 1737567..1738262(-) (comEA) [Streptococcus salivarius strain MRD-NRLLH]
GTGAAGGAAAAGATTCTAGCCTATGTCAAAGATAATCGTTTGTTTGTGAGTGTCATCGCTGTACTGATGGTGATTTTTTG
CTTCTTTCTATGGATGACTTGTGGTGCCGGCAACAGCATGGAGGCGGAGACGTCTTATACAGATGTGACAACATTGTCAA
CCTCCTCATCCAAACAAGGTTCACAGTCTCTTTCTGAGGCGTCTTCCCAGTCAAAGACTGAAGAAAGTGAAAAGGATAAG
TCAAAAGTAACAGTGGATGTTAAGGGAGCCGTAGTCAAGCCAGGGGTTTATACGCTAAAAGCGGGCACTAGAGTGACTGA
CGCCATCAAAGCCGCTGGGGGAATGACCGAGGATGCGGATGCTAAGAGTATTAATTTAGCCGCAAGCTTGTCAGACGAAG
AGGTTATCTATGTGGCAACTAAGGATGAAAACCTTTCTGTCCTTGGTCAATCAGGAACTAGTCAGGTTTCTGACAAAGGA
GGGCAAACAAATGCTAAGGATGGGAAAATTAACTTAAATACAGCGACTGCAGAGGAATTGCAAACCATTTCTGGAATTGG
AGCTAAGCGAGCAGAGGATATCATCGCCTATCGCGAAAGTCATGGCGGCTTTCAGTCCGTAGATGACCTGAAAAATGTTT
CAGGAATTGGTGATAAAACGTTAGATAAAATCAGAGAGTCCATCTATGTGGCTTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(85-138)

Helix-hairpin-helix motif (HHH_3)

(168-228)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TU97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA Streptococcus thermophilus LMD-9

90.476

100

0.905
  comEA/celA/cilE Streptococcus mitis SK321

40.435

99.567

0.403
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

40.175

99.134

0.398
  comEA/celA/cilE Streptococcus pneumoniae Rx1

39.035

98.701

0.385
  comEA/celA/cilE Streptococcus pneumoniae D39

39.035

98.701

0.385
  comEA/celA/cilE Streptococcus pneumoniae R6

39.035

98.701

0.385

Multiple sequence alignment